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An Investigation on Zirconia Nano-particles Coating Deposited on Magnesium AZ91 alloy Using Electrodeposition Method
, M.Sc. Thesis Sharif University of Technology ; Afshar, Abdollah (Supervisor)
Abstract
Recently magnesium alloys have shown great potential as biodegradable metallic implants. However, due to high corrosion rate in the body environment, these alloys would be degraded before the tissue healing time period. Therefore corrosion resistance of these alloys has to be improved in order to be used in biological environments. In the present work, supposing improvement of corrosion properties of magnesium AZ91D alloy, the alloy has been coated with biocompatible nano-Zirconia particles using Electrophoretic deposition method and the effects of deposition parameters such as bath agitation, Zirconia concentration, current density and duration of deposition process on the properties of the...
Preparation and Characterization of HA/ZrO2 Biocomposite Coating on 316 Stainless Steel Fabricated by Electrodeposition
, M.Sc. Thesis Sharif University of Technology ; Afshar, Abdollah (Supervisor)
Abstract
In this research, role of zirconia nanoparticles as a biocompatible material which has great mechanical properties, was investigated on corrosion behavior and bonding strength of HA coating. HA- ZrO2 composite prepared by a 2-step pulse electrodeposition method. Effect of pH (3.5, 4.5), bath temperature (60, 80 ͦC), current density (0.5, 1, 2 mA/cm2) and zirconia concentration (5, 10, 15 g/L) on coating characteristics were studied. X-ray diffraction was employed for phase analysis. Morphology and microstructure of samples observed utilizing scanning electron microscope (SEM) and elemental analysis was done by EDS. In order to corrosion studies electrochemical impedance spectroscopy (EIS)...
Effect of Fluorine Addition on Properties of Electrodeposited Fluorine-doped Hydroxyapatite Coating on AZ31 alloy
, M.Sc. Thesis Sharif University of Technology ; Afshar, Abdollah (Supervisor)
Abstract
Magnesium and its alloys are potentialy biodegradable implant materials due to their attractive biological properties. But their poor corrosion resistance may result in sudden failure of the implants. Recently, many researchers have focused on applications of fluorine-doped hydroxyapatiteCa10(PO4)6(OH)2−xFx (FHA, x is the degree of fluoridation) as a bioactive coating to provide early stability and long-term performance. In comparison with pure HA coating,FHA coating could provide significant dissolution-resistant property, better apatite-like layer deposition, better protein adsorption, better cell attachment and improved alkaline phosphatase activity in cell culture. In this...
Preparation and Characterisation of Titania-hydroxyapatite-carbon
Nanotube Nanostructured Bioceramics by Sol-gel Process
,
M.Sc. Thesis
Sharif University of Technology
;
Mohammadi, Mohammad Reza
(Supervisor)
Abstract
Hydroxyapatite (HA) is an attractive biomaterial due to its close chemical composition to bone and teeth. However, HA is brittle and has low strength under bearing loads, resulting in limition for orthopedic and dental applications. Two creative approaches have been developed to overcome this problem, using bioactive HA as coatings on metallic implants or as ceramic/metal composites. Carbon nanotubes (CNT) possess excellent mechanical properties to play the role as reinforcement for imparting strength and toughness to brittle hydroxyapatite (HA) bioceramic coating. Moreover, The addition of TiO2 to HA coatings has attracted considerable attention, since TiO2 is capable of increasing the...
A critical review of bioceramics for magnetic hyperthermia
, Article Journal of the American Ceramic Society ; 2021 ; 00027820 (ISSN) ; Alaghmandfard, A ; Montazerian, M ; Baino, F ; Sharif University of Technology
Blackwell Publishing Inc
2021
Abstract
Magnetic hyperthermia (HT) using biocompatible ceramics is a ground-breaking, competent, and safe thermo-therapeutic strategy for cancer treatment. The magnetic properties of bioceramics, along with their structure and synthesis parameters, are responsible for the controlled heating of malignant tumors and are the key to clinical success. After providing a brief overview of magnetism and its significance in biomedicine, this review deals with materials selection and synthesis methods of bioceramics/glasses used for HT. Relevant research carried out on promising bioceramics for magnetic HT, with a focus on their size, shape, surface functionalization, magnetic field parameters, and in...
A critical review of bioceramics for magnetic hyperthermia
, Article Journal of the American Ceramic Society ; Volume 105, Issue 3 , 2022 , Pages 1723-1747 ; 00027820 (ISSN) ; Alaghmandfard, A ; Montazerian, M ; Baino, F ; Sharif University of Technology
John Wiley and Sons Inc
2022
Abstract
Magnetic hyperthermia (HT) using biocompatible ceramics is a ground-breaking, competent, and safe thermo-therapeutic strategy for cancer treatment. The magnetic properties of bioceramics, along with their structure and synthesis parameters, are responsible for the controlled heating of malignant tumors and are the key to clinical success. After providing a brief overview of magnetism and its significance in biomedicine, this review deals with materials selection and synthesis methods of bioceramics/glasses used for HT. Relevant research carried out on promising bioceramics for magnetic HT, with a focus on their size, shape, surface functionalization, magnetic field parameters, and in...
Evaluation of bioactivity and biocompatibility of silk fibroin/TiO2 nanocomposite
, Article Journal of Medical and Biological Engineering ; Volume 38, Issue 1 , February , 2018 , Pages 99-105 ; 16090985 (ISSN) ; Madaah Hosseini, H. R ; Taromi, N ; Arasteh, S ; Kazemnejad, S ; Samadi Kuchaksaraei, A ; Sharif University of Technology
Springer Berlin Heidelberg
2018
Abstract
Biodegradable polymer/bioceramic nanocomposites are osteoconductive and can accelerate healing of bone tissue. In this research, silk fibroin (SF)/titanium dioxide (TiO2) nanocomposites were synthesized using different concentrations of TiO2 nanoparticles (0, 5, 10, 15 and 20 wt%). The SF/TiO2 nanocomposites were studied in terms of bioactivity and biocompatibility. The in vitro assessment of osteoblasts compatibility indicated that SF inclusion rendered nanocomposite biocompatible whereas presence of TiO2 nanoparticles allowed the cells to adhere and grow on nanocomposite surface and enhanced the bioactivity of the composite. © 2017, Taiwanese Society of Biomedical Engineering
Fabrication of HAp-8YSZ composite layer on Ti/TiO2 nanoporous substrate by EPD/MAO method
, Article Materials Letters ; Volume 65, Issue 23-24 , 2011 , Pages 3421-3423 ; 0167577X (ISSN) ; Moshayedi, Sh ; Ghaffari, S. A ; Rezaei, H. R ; Golestani Fard, F ; Sharif University of Technology
Abstract
Zirconia/Hydroxyapatite composites containing 20-50 wt.% 8YSZ were prepared on Ti/TiO2 substrates by electrophoretic deposition (EPD)/micro-arc oxidation (MAO) process. Titania, as an inner layer, was grown on the Ti plates using MAO treatment in order to form a strong join between substrate and HAp. These composites were produced by EPD in ethanol containing ZrO2/HAp particles at 50, 100 and 150 V in 1 min. Asprepared samples were sintered at 900, 1100 and 1300 °C. HAp, β-TCP, CaZrO3 phases were identified using X-ray diffractometry analysis (XRD). Scanning electron microscopy (SEM) utilized to study the surface morphology indicated a crack free microstructure at 1300 °C
Radiopaque crystalline, non-crystalline and nanostructured bioceramics
, Article Materials ; Volume 15, Issue 21 , 2022 ; 19961944 (ISSN) ; Gonçalves, G. V. S ; Barreto, M. E. V ; Lima, E. P. N ; Cerqueira, G. R. C ; Sousa, J. A ; Malek Khachatourian, A ; Souza, M. K. S ; Silva, S. M. L ; Fook, M. V. L ; Baino, F ; Sharif University of Technology
MDPI
2022
Abstract
Radiopacity is sometimes an essential characteristic of biomaterials that can help clinicians perform follow-ups during pre- and post-interventional radiological imaging. Due to their chemical composition and structure, most bioceramics are inherently radiopaque but can still be doped/mixed with radiopacifiers to increase their visualization during or after medical procedures. The radiopacifiers are frequently heavy elements of the periodic table, such as Bi, Zr, Sr, Ba, Ta, Zn, Y, etc., or their relevant compounds that can confer enhanced radiopacity. Radiopaque bioceramics are also intriguing additives for biopolymers and hybrids, which are extensively researched and developed nowadays for...
Effect of electrolyte concentration on microstructure and properties of micro arc oxidized hydroxyapatite/titania nanostructured composite
, Article Materials Science and Engineering C ; Volume 33, Issue 5 , 2013 , Pages 2555-2561 ; 09284931 (ISSN) ; Golestani Fard, F ; Mirhosseini, S. M. M ; Ziaee, A ; Mehrjoo, M ; Sharif University of Technology
2013
Abstract
Micro arc oxidation was employed to grow TiO2/hydroxyapatite composite layer on titanium substrate. The correlation between electrolyte concentration, diameter and density of the pores in fabricated layers was investigated. Therefore, the effect of electrolyte concentration on composition and morphology of grown layers was studied using SEM, EDX, XRD and XPS techniques. Samples were coated in electrolytes containing 5, 10 and 15 g/l calcium acetate and 1, 3 and 5 g/l β-glycerophosphate, at optimized voltage for 3 min. Pore size variations obey a similar pattern by the addition of both calcium acetate and β-glycerophosphatein various concentrations based on SEM observations. However,...
Synthesis and characterization of bioactive glass/forsterite nanocomposites for bone and dental implants
, Article Ceramics - Silikaty ; Volume 56, Issue 4 , 2012 , Pages 331-340 ; 08625468 (ISSN) ; Yazdanpanah, A ; Moztarzadeh, F ; Ravarian, R ; Moztarzadeh, Z ; Tahmasbi, M ; Mozafari, M ; Sharif University of Technology
2012
Abstract
In this research, bioactive glass (BG) of the type CaO-P2O 5-SiO2 and nanocrystalline forsterite (NF) bioceramic were successfully synthesized via sol-gel processing method. Heat-treatment process was done to obtain phase-pure nanopowders. After characterization of each sample, the nanocomposite samples were prepared by cold pressing method and sintered at 1000°C. The samples were fully characterized by X-ray powder diffraction (XRD), scanning electron microscope (SEM), energy dispersive spectroscopy (EDX), Fourier transform infrared spectroscopy (FTIR) analyses. The average nanocrystallite size was determined using the Debye-Scherrer's formula 19.6 nm. The bioactivity was examined in vitro...
Influence of Fe3O4 nanoparticles in hydroxyapatite scaffolds on proliferation of primary human fibroblast cells
, Article Journal of Materials Engineering and Performance ; 2016 , Pages 1-9 ; 10599495 (ISSN) ; Aghaie, E ; Nadernezhad, A ; Zargarzadeh, M ; Khakzad, A ; Shakeri, M. S ; Beygi Khosrowshahi, Y ; Siadati, M. H ; Sharif University of Technology
Springer New York LLC
2016
Abstract
Modern techniques for expanding stem cells play a substantial role in tissue engineering: the raw material that facilitates regeneration of damaged tissues and treats diseases. The environmental conditions and bioprocessing methods are the primary determinants of the rate of cultured stem cell proliferation. Bioceramic scaffolds made of calcium phosphate are effective substrates for optimal cell proliferation. The present study investigates the effects of two bioceramic scaffolds on proliferating cells in culture media. One scaffold was made of hydroxyapatite and the other was a mixture of hydroxyapatite and ferromagnetic material (Fe3O4 nanoparticles). Disk-shaped (10 mm × 2 mm) samples of...
Mechanical modeling of silk fibroin/TiO2 and silk fibroin/fluoridated TiO2 nanocomposite scaffolds for bone tissue engineering
, Article Iranian Polymer Journal (English Edition) ; Volume 29, Issue 3 , February , 2020 , Pages 219-224 ; Madaah Hosseini, H. R ; Samadikuchaksaraei, A ; Sharif University of Technology
Springer
2020
Abstract
Biocompatible and biodegradable three-dimensional scaffolds are commonly porous which serve to provide suitable microenvironments for mechanical supporting and optimal cell growth. Silk fibroin (SF) is a natural and biomedical polymer with appropriate and improvable mechanical properties. Making a composite with a bioceramicas reinforcement is a general strategy to prepare a scaffold for hard tissue engineering applications. In the present study, SF was separately combined with titanium dioxide (TiO2) and fluoridated titanium dioxide nanoparticles (TiO2-F) as bioceramic reinforcements for bone tissue engineering purposes. At the first step, SF was extracted from Bombyx mori cocoons. Then,...
Biological evaluation of a novel tissue engineering scaffold of Layered Double Hydroxides (LDHs)
, Article Key Engineering Materials, 6 November 2011 through 9 November 2011 ; Volume 493-494 , November , 2012 , Pages 902-908 ; 10139826 (ISSN) ; 9783037852552 (ISBN) ; Solati Hashjin, M ; Shokrgozar, M. A ; Bonakdar, S ; Ganji, Y ; Mirjordavi, N ; Ghavimi, S. A ; Khashayar, P ; Sharif University of Technology
2012
Abstract
Bone Tissue Engineering (BTE) composed of three main parts: scaffold, cells and signaling factors. Several materials and composites are suggested as a scaffold for BTE. Biocompatibility is one of the most important property of a BTE scaffold. In this work synthesis of a novel nanocomposite including layered double hydroxides (LDH) and gelatin is carried out and its biological properties were studied. The co-precipitation (pH=11) method was used to prepare the LDH powder, using calcium nitrate, Magesium nitrate and aluminum nitrate salts as starting materials. The resulted precipitates were dried. X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and scanning electron...
Multifunctional conductive biomaterials as promising platforms for cardiac tissue engineering
, Article ACS Biomaterials Science and Engineering ; Volume 7, Issue 1 , 2021 , Pages 55-82 ; 23739878 (ISSN) ; Vahdat, S ; Baheiraei, N ; Razavi, M ; Norahan, M. H ; Baharvand, H ; Sharif University of Technology
American Chemical Society
2021
Abstract
Adult cardiomyocytes are terminally differentiated cells that result in minimal intrinsic potential for the heart to self-regenerate. The introduction of novel approaches in cardiac tissue engineering aims to repair damages from cardiovascular diseases. Recently, conductive biomaterials such as carbon- and gold-based nanomaterials, conductive polymers, and ceramics that have outstanding electrical conductivity, acceptable mechanical properties, and promoted cell-cell signaling transduction have attracted attention for use in cardiac tissue engineering. Nevertheless, comprehensive classification of conductive biomaterials from the perspective of cardiac cell function is a subject for...
Recent progress in inorganic and composite coatings with bactericidal capability for orthopaedic applications
, Article Nanomedicine: Nanotechnology, Biology, and Medicine ; Volume 7, Issue 1 , Feb , 2011 , Pages 22-39 ; 15499634 (ISSN) ; Tamjid, E ; Pishbin, F ; Boccaccini, A. R ; Sharif University of Technology
Abstract
This review covers the most recent developments of inorganic and organic-inorganic composite coatings for orthopedic implants, providing the interface with living tissue and with potential for drug delivery to combat infections. Conventional systemic delivery of drugs is an inefficient procedure that may cause toxicity and may require a patient's hospitalization for monitoring. Local delivery of antibiotics and other bioactive molecules maximizes their effect where they are required, reduces potential systemic toxicity and increases timeliness and cost efficiency. In addition, local delivery has broad applications in combating infection-related diseases. Polymeric coatings may present some...