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    Production of chitosan by submerged fermentation from Aspergillus niger

    , Article Scientia Iranica ; Volume 16, Issue 2 C , 2009 , Pages 145-148 ; 10263098 (ISSN) Maghsoodi, V ; Razavi, J ; Yaghmaei, S ; Sharif University of Technology
    2009
    Abstract
    The effect of glucose concentration in submerged fermentation (SMF) on chitosan production by Aspergillus niger was investigated. A. niger, BBRC, 20004, from the Biochemical and Bioenvironmental Research Centre at Sharif University of Technology, Tehran, Iran, was grown in a Sabouro Dextrose media. Chitosan was extracted from the fungal mycelia using hot alkaline and acid treatment and after 12 days of cultivation, 0.8455 g chitosan /l of the fermentation medium was obtained. The content of glucose in the Sobouro Dextrose Broth media was also changed and the highest yield of chitosan 0.9121 g/l was obtained in Sobouro Dextrose Broth media containing 8% glucose. © Sharif University of... 

    Enzymatic synthesis of amoxicillin with immobilized penicillin G acylase

    , Article Scientia Iranica ; Volume 17, Issue 1 C , 2010 , Pages 106-113 ; 10263098 (ISSN) Alemzadeh, I ; Borghei, G ; Vafi, L ; Roostaazad, R ; Sharif University of Technology
    2010
    Abstract
    The synthesis of amoxicillin with immobilized penicillin G acylase (PGA) in aqueous medium was investigated. The parameters studied were: time course of amoxicillin production, concentration of substrates: hydroxyphenylglycine methyl ester (HPGM) and 6-aminopeicillanic acid (6-APA) and the. effect of enzyme (PGA) content and pH, under variable and constant conditions and temperature variations. In the study of two substrate concentration on amoxicillin production, impressive results were obtained for a 1/3 ratio of 6-amino penicillanic acid (6-APA) and hydroxyl-phenylglycine methyl ester (HPGM). The. synthesis of amoxicillin was preferable at constant pH rather than a variable one. Other... 

    Bioleaching of tungsten-rich spent hydrocracking catalyst using Penicillium simplicissimum

    , Article Bioresource Technology ; Volume 102, Issue 2 , January , 2011 , Pages 1567-1573 ; 09608524 (ISSN) Amiri, F ; Yaghmaei, S ; Mousavi, S. M ; Sharif University of Technology
    2011
    Abstract
    Adaptation of Penicillium simplicissimum with different heavy metals present in a spent hydrocracking catalyst, as well as one-step, two-step, and spent medium bioleaching of the spent catalyst by the adapted fungus, was examined in batch cultures. Adaptation experiments with the single metal ions Ni, Mo, Fe, and W showed that the fungus could tolerate up to 1500. mg/L Ni, 8000. mg/L Mo, 3000. mg/L Fe, and 8000. mg/L W. In the presence of multi-metals, the fungus was able to tolerate up to 300. mg/L Ni, 200. mg/L Mo, 150. mg/L Fe and 2500. mg/L W. A total of 3% (w/v) spent catalyst generally gave the maximum extraction yields in the two-step bioleaching process (100% of W, 100% of Fe, 92.7%... 

    Integrative Utilization of Microenvironments, Biomaterials and Computational Techniques for Advanced Tissue Engineering

    , Article Journal of Biotechnology ; Volume 212 , 2015 , Pages 71-89 ; 01681656 (ISSN) Shamloo, A ; Mohammadaliha, N ; Mohseni, M ; Sharif University of Technology
    Elsevier  2015
    Abstract
    This review aims to propose the integrative implementation of microfluidic devices, biomaterials, and computational methods that can lead to a significant progress in tissue engineering and regenerative medicine researches. Simultaneous implementation of multiple techniques can be very helpful in addressing biological processes. Providing controllable biochemical and biomechanical cues within artificial extracellular matrix similar to in vivo conditions is crucial in tissue engineering and regenerative medicine researches. Microfluidic devices provide precise spatial and temporal control over cell microenvironment. Moreover, generation of accurate and controllable spatial and temporal... 

    Public ingestion exposure to 226Ra in Ramsar, Iran

    , Article Journal of Environmental Radioactivity ; Volume 198 , 2019 , Pages 11-17 ; 0265931X (ISSN) Fathabadi, N ; Salehi, A. A ; Naddafi, K ; Kardan, M. R ; Yunesian, M ; Nodehi, R. N ; Deevband, M. R ; Shooshtari, M. G ; Sharif University of Technology
    Elsevier Ltd  2019
    Abstract
    Ramsar, in the north of Iran by the Caspian Sea, has been known for the highest natural radiation background on Earth due to the local geology and hydrogeology. The residents and visitors use the hot springs that distribute the natural radionuclides especially 226Ra and its decay products in the areas. Many studies have been undertaken to measure the absorbed dose rate in Ramsar's air, however, no survey has been done to assess public internal exposure from ingestion of natural radionuclides, such as, a broad survey for 226Ra was conducted in foodstuffs and drinking water. This study presents the results of public annual activity intake (Bq) and effective dose (μSv) from ingestion of 226Ra... 

    Fe3O4@PAA@UiO-66-NH2 magnetic nanocomposite for selective adsorption of Quercetin

    , Article Chemosphere ; Volume 275 , 2021 ; 00456535 (ISSN) Ahmadijokani, F ; Tajahmadi, S ; Haris, M. H ; Bahi, A ; Rezakazemi, M ; Molavi, H ; Ko, F ; Arjmand, M ; Sharif University of Technology
    Elsevier Ltd  2021
    Abstract
    In the present study, a magnetic core-shell metal-organic framework (Fe3O4@PAA@UiO-66-NH2) nanocomposite was synthesized by a facile step-by-step self-assembly technique and used for selective adsorption of the anti-cancer Quercetin (QCT) drug. The synthesized nanocomposite was well characterized using FTIR, XRD, BET, FESEM, and TEM techniques. The adsorption kinetics and isotherms of the magnetic nanocomposites for QCT were investigated in detail at different initial concentrations and temperatures. It was found that the experimental adsorption kinetic and isotherm data were precisely explained by the pseudo-second-order kinetic and Langmuir isotherm models. Moreover, the selective... 

    Fe3O4@PAA@UiO-66-NH2 magnetic nanocomposite for selective adsorption of Quercetin

    , Article Chemosphere ; Volume 275 , 2021 ; 00456535 (ISSN) Ahmadijokani, F ; Tajahmadi, S ; Haris, M. H ; Bahi, A ; Rezakazemi, M ; Molavi, H ; Ko, F ; Arjmand, M ; Sharif University of Technology
    Elsevier Ltd  2021
    Abstract
    In the present study, a magnetic core-shell metal-organic framework (Fe3O4@PAA@UiO-66-NH2) nanocomposite was synthesized by a facile step-by-step self-assembly technique and used for selective adsorption of the anti-cancer Quercetin (QCT) drug. The synthesized nanocomposite was well characterized using FTIR, XRD, BET, FESEM, and TEM techniques. The adsorption kinetics and isotherms of the magnetic nanocomposites for QCT were investigated in detail at different initial concentrations and temperatures. It was found that the experimental adsorption kinetic and isotherm data were precisely explained by the pseudo-second-order kinetic and Langmuir isotherm models. Moreover, the selective...