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biodegradable-coating
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Characterization and antibacterial performance of electrodeposited chitosan–vancomycin composite coatings for prevention of implant-associated infections [electronic resource]
, Article Journal of Materials Science and Engineering: C ; 1 August 2014, Volume 41, Pages 240–248 ; Tamjid, E ; Simchi, A. (Abdolreza) ; Sharif University of Technology
Abstract
Orthopaedic implant-associated infections are one of the most serious complications in orthopaedic surgery and a major cause of implant failure. In the present work, drug-eluting coatings based on chitosan containing various amounts of vancomycin were prepared by a cathodic electrophoretic deposition process on titanium foils. A three-step release mechanism of the antibiotic from the films in a phosphate-buffered saline solution was noticed. At the early stage, physical encapsulation of the drug in the hydrogel network controlled the release rate. At the late stage, however, in vitro degradation/deattachment of chitosan was responsible for the controlled release. Cytotoxicity evaluation of...
Electrophoretic deposition of nano-zirconia coating on AZ91D magnesium alloy for bio-corrosion control purposes
, Article Surface and Coatings Technology ; Volume 311 , 2017 , Pages 182-190 ; 02578972 (ISSN) ; Mohammadi, I ; Afshar, A ; Sharif University of Technology
Elsevier B.V
2017
Abstract
Magnesium alloys are considered as potential biodegradable biomaterials in hard tissue implants. However, the fast degradation rate of these alloys in the biological environment causes failure of the implant just prior to the desirable time. In the present work, in order to decrease and curb the bio-corrosion rate of AZ91D Magnesium alloy, zirconia, which is classified as a biocompatible ceramic, was coated on the alloy surface through electrophoretic deposition (EPD) technique. The effects of alterations in the EPD parameters such as current density, duration time and ZrO2 particles concentration on coating properties including thickness, morphology and adhesion were then characterized....