Search for: biological-assay
Synthesis of Graphene Structures by Chemical Vapor Deposition Method and Evaluation of their Electrical and Biological Properties, M.Sc. Thesis Sharif University of Technology ; Simchi, Abdolreza
Graphene is a newly developed nanomaterial that has resived considerable attention in recent years. Graphene – based structures having remarkable properties, e.g. high specific surface area, ultrahigh electrical conductivity and good biocompability, are ideal choices for nanomedical applications such as biosensors and cell culture scaffolds. So, in this project 2D graphene and 3D graphene foam structures were synthesized by chemical vapor deposition (CVD) method and their electrical and biological properties were evaluated. First step of this project was to design and make a CVD system suitable for the synthesis of high quality graphene structures, i.e. single layer graphene and 3D graphene...
Improving the Biomedical Performance of Metal–Organic Frameworks in Drug Delivery Systems: in Vitro Studies, M.Sc. Thesis Sharif University of Technology ; Bagherzadeh, Mojtaba
In this study, water-stable metal-organic frameworks, UiO-66-(CO2H)2, MIL-53-NH2 (Al), ZIF-8 and MIP-202 (Zr), were selected to study the influence of using plant extracts in drug loading process and also its targeted release from these compounds. For this purpose, at first the solution of different plant extracts was used separately as a synthetic solvent in the preparation of the desired MOFs to be present in the structure of these compounds and increase the interaction of the drug with the nanocarrier. Then, a coating of plant extract was applied on the nanocarrier containing the drug after loading the drug to prevent the rapid penetration of the drug from the cavities of MOFs (drug...
Study on the Performance of Magnetic Nanoparticles in Hyper-thermic Treatment of Cancerous Tumors, by Heating an MRI Apparatus, M.Sc. Thesis Sharif University of Technology ; Outokesh, Mohammad ; Nourani, Mohammad Reza
The aim of this study was to investigate the rate of increase in temperature of a phantom equivalent to body tissue by different groups of magnetic iron nanoparticles in the external magnetic field to kill cancer cells based on the hyperthermia method. To achieve this goal, three groups of dextran magnetic nanoparticles with different properties and reduced iron oxide-graphene oxide magnetic nanoparticles by M-rGO supercritical synthesis method were used. After XRD, FTIR, SEM, FESEM, VSM, TEM characterization tests, these materials were placed in a phantom made of agarose gel and with the same properties, in a magnetic field with fixed characteristics for all groups and during the process of...
Article Nanomedicine: Nanotechnology, Biology, and Medicine ; Volume 30 , November , 2020 ; Rabiee, N ; Bagherzadeh, M ; Ghadiri, A. M ; Fatahi, Y ; Dinarvand, R ; Webster, T. J ; Sharif University of Technology
Elsevier Inc 2020
This study investigated the synthesis of Pd nanoparticles (NPs) using a high-gravity technique mediated by Salvia hispanica leaf extracts. Biological assays confirmed their antibacterial activity against gram positive (S. aureus) and gram negative (E. coli) bacteria with significant antioxidant activity in comparison with the standards as well as low cellular toxicity on PC12 and HEK293 cell lines. To the best of our knowledge, this study can be considered as the first investigation of Pd-NPs synthesized by Salvia hispanica leaf extracts assisted by a high-gravity technique. In addition, the mentioned green synthesis procedure led to the formation of nanoparticles with considerable...
Multi-walled carbon nanotubes with immobilised cobalt nanoparticle for modification of glassy carbon electrode: Application to sensitive voltammetric determination of thioridazine, Article Biosensors and Bioelectronics ; Volume 24, Issue 11 , 2009 , Pages 3235-3241 ; 09565663 (ISSN) ; Ghalkhani, M ; Adeli, M ; Amini, M. K ; Sharif University of Technology
Multi-walled carbon nanotubes (MWCNTs) were immobilised with cobalt nanoparticles and analyzed by transmission electron microscopy. This modification procedure substantially improved colloidal dispersion of the immobilised MWCNTs in water and organic solvents, yielding uniform and stable thin films for modification of the glassy carbon electrode surface. The modified electrode showed an efficient catalytic role for the electrochemical oxidation of thioridazine (TR), leading to remarkable decrease in its oxidation overpotential of approximately 100 mV and enhancement of the kinetics of the electrode reaction, which can be confirmed by increasing in the peak current and sharpness of the peak....