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Simulation of the Cellular Dynamics of Bone Remodeling and its Control Mechanisms
, M.Sc. Thesis Sharif University of Technology ; Zohoor, Hassan (Supervisor) ; Sohrabpour, Saeed (Co-Advisor)
Abstract
Bone is one of the most important biomechanical organs in animal bodies which comprises of a dynamic tissue that can change its internal structure through remodeling process. A comprehensive understanding of this process is of great significance in prevention and cure of many bone diseases. Due to the special conditions of hard bone tissue, empirical studies on the details of bone processes is very costly and time consuming. Thus, mathematical models and in silico simulations are key to unraveling how bone homeostasis imbalance can lead to pathological conditions. Therefore, in the recent years, there has been an increasing interest in modeling bone remodeling process in cellular level. In...
Evaluation of Adaptability in Biological Models
, M.Sc. Thesis Sharif University of Technology ; Tavazoei, Mohammad Saleh (Supervisor)
Abstract
Adaptation is a recurring phenomenon in biology by which biochemical systems can robustly- and in some cases completely- adapt their regulated outputs to en- vironmental disturbances and uncertainties. In nature, such a feature has been evolved in biological circuits through the construction of integral feedback control structures. Three types of biologically plausible controllers have been recently in- troduced which can ensure the existence of robust perfect adaptation for arbitrary plants. In this thesis, the main purpose is to have a comparison between them. To this end, we first find a stability criterion to relate the system’s stability with its internal parameters. We then calculate a...