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    Interdisciplinary challenges and promising theranostic effects of nanoscience in Alzheimer's disease

    , Article RSC Advances ; Volume 2, Issue 12 , 2012 , Pages 5008-5033 ; 20462069 (ISSN) Laurent, S ; Ejtehadi, M. R ; Rezaei, M ; Kehoe, P. G ; Mahmoudi, M ; Sharif University of Technology
    2012
    Abstract
    During the last decade, reports show that the incidence and prevalence of Alzheimer's disease (AD) and other dementias have significantly increased. AD poses an enormous escalating threat to health services and resources. Early diagnosis of AD is recognized as one of the major challenges and primary aims in scientific communities. With the arrival of nanoscience and nanotechnology to medicine, hopes for early diagnosis and treatment of AD have considerably increased. To this end, nanobioresearchers are focused on three major areas consisting of early detection and recognition, biological markers and diagnosis, and pharmacotherapy. Several efforts are in progress for the discovery of new... 

    Metabolic profiling of seminal plasma from teratozoospermia patients

    , Article Journal of Pharmaceutical and Biomedical Analysis ; Volume 178 , January , 2020 Mehrparvar, B ; Chashmniam, S ; Nobakht, F ; Amini, M ; Javidi, A ; Minai Tehrani, A ; Arjmand, B ; Gilany, K ; Sharif University of Technology
    Elsevier B. V  2020
    Abstract
    Teratozoospermia is one of conditions that can cause male infertility. The mechanism of teratozoospermia remains unclear. The knowledge of the metabolites in human seminal plasma (HSP) is meaningful for the pathological study of teratozoospermia. Analysis of changed metabolites in HSP can help understand the cellular mechanism, find the novel biomarkers and subsequently design a diagnosis test. In this study, the analysis of samples performed by proton nuclear magnetic resonance spectroscopy (1H NMR spectroscopy) to identify the various metabolites, with the aim of finding metabolic profiles and biomarkers related to male infertility. Eighteen de-regulated metabolites were identified in... 

    Whole-genome analysis of de novo somatic point mutations reveals novel mutational biomarkers in pancreatic cancer

    , Article Cancers ; Volume 13, Issue 17 , 2021 ; 20726694 (ISSN) Ghareyazi, A ; Mohseni, A ; Dashti, H ; Beheshti, A ; Dehzangi, A ; Rabiee, H. R ; Alinejad Rokny, H ; Sharif University of Technology
    MDPI  2021
    Abstract
    It is now known that at least 10% of samples with pancreatic cancers (PC) contain a causative mutation in the known susceptibility genes, suggesting the importance of identifying cancer-associated genes that carry the causative mutations in high-risk individuals for early detection of PC. In this study, we develop a statistical pipeline using a new concept, called gene-motif, that utilizes both mutated genes and mutational processes to identify 4211 3-nucleotide PC-associated gene-motifs within 203 significantly mutated genes in PC. Using these gene-motifs as distinguishable features for pancreatic cancer subtyping results in identifying five PC subtypes with distinguishable phenotypes and... 

    Association of biomarkers of systemic inflammation with organic components and source tracers in quasi-ultrafine particles

    , Article Environmental Health Perspectives ; Volume 118, Issue 6 , 2010 , Pages 756-762 ; 00916765 (ISSN) Delfino, R. J ; Staimer, N ; Tjoa, T ; Arhami, M ; Polidori, A ; Gillen, D. L ; Kleinman, M. T ; Schauer, J. J ; Sioutas, C ; Sharif University of Technology
    2010
    Abstract
    Background: Evidence is needed regarding the air pollutant components and their sources responsible for associations between particle mass concentrations and human cardiovascular outcomes. We previously found associations between circulating biomarkers of inflammation and mass concentrations of quasi-ultrafine particles ≤ 0.25 μm in aerodynamic diameter (PM0.25) in a panel cohort study of 60 elderly subjects with coronary artery disease living in the Los Angeles Basin.Objectives: We reassessed biomarker associations with PM0.25 using new particle composition data.Methods: Weekly biomarkers of inflammation were plasma interleukin-6 (IL-6) and soluble tumor necrosis factor-α receptor II... 

    1H NMR based metabolic profiling in Crohn's disease by random forest methodology

    , Article Magnetic Resonance in Chemistry ; Vol. 52, issue. 7 , July , 2014 , p. 370-376 Fathi, F ; Majari-Kasmaee, L ; Mani-Varnosfaderani, A ; Kyani, A ; Rostami-Nejad, M ; Sohrabzadeh, K ; Naderi, N ; Zali, M. R ; Rezaei-Tavirani, M ; Tafazzoli, M ; Arefi-Oskouie, A ; Sharif University of Technology
    Abstract
    The present study was designed to search for metabolic biomarkers and their correlation with serum zinc in Crohn's disease patients. Crohn's disease (CD) is a form of inflammatory bowel disease that may affect any part of the gastrointestinal tract and can be difficult to diagnose using the clinical tests. Thus, introduction of a novel diagnostic method would be a major step towards CD treatment.Proton nuclear magnetic resonance spectroscopy ( 1H NMR) was employed for metabolic profiling to find out which metabolites in the serum have meaningful significance in the diagnosis of CD. CD and healthy subjects were correctly classified using random forest methodology. The classification model for... 

    Metabonomics exposes metabolic biomarkers of Crohn's disease by 1HNMR

    , Article Gastroenterology and Hepatology from Bed to Bench ; Volume 6, Issue SUPPL , 2013 , Pages S19-S22 ; 2008-4234 (EISSN) Fathi, F ; Ektefa, F ; Hagh-Azali, M ; Aghdaie, H. A ; Sharif University of Technology
    2013
    Abstract
    Metabonomics and other "omic" fields are essential science in analytical chemistry. Modern analytical instruments such as proton nuclear magnetic resonance (1H-NMR) can provide the great quantity of analytical information. In order to assign unknown samples, chemometric methods recognition build classification model based on experimental data. Firstly, some current strategies regarding disease diagnosis are exhibited in metabonomic studies. Some diseases such as crohn's disease can be difficult to diagnose since its signs and symptoms may be similar to other medical problems or often mimic other symptoms. Applications of NMR and supervised pattern recognition in the field of metabonomics are... 

    Metabonomics based NMR in Crohn's disease applying PLS-DA

    , Article Gastroenterology and Hepatology from Bed to Bench ; Volume 6, Issue SUPPL , 2013 , Pages S82-S86 ; 20082258 (ISSN) Fathi, F ; Oskouie, A. A ; Tafazzoli, M ; Naderi, N ; Sohrabzedeh, K ; Fathi, S ; Norouzinia, M ; Nejad, M. R ; Sharif University of Technology
    2013
    Abstract
    Aim: The aim of this study was to search for metabolic biomarkers of Crohn's disease (CD). Background: Crohn's disease (CD) is a type of inflammatory bowel disease that causes a wide variety of symptoms. CD can influence any part of the gastrointestinal tract from mouth to anus. CD is not easily diagnosed because monitoring tools are currently insufficient. Thus, the discovery of proper methods is needed for early diagnosis of CD. Patients and methods: We utilized metabolic profiling using proton nuclear magnetic resonance spectroscopy (1HNMR) to find the metabolites in serum. Classification of CD and healthy subject was done using partial least squares discriminant analysis (PLS-DA).... 

    NMR- and GC/MS-based metabolomics of sulfur mustard exposed individuals: a pilot study

    , Article Biomarkers ; Volume 21, Issue 6 , 2016 , Pages 479-489 ; 1354750X (ISSN) Nobakht, B. F ; Aliannejad, R ; Rezaei Tavirani, M ; Arefi Oskouie, A ; Naseri, M. T ; Parastar, H ; Aliakbarzadeh, G ; Fathi, F ; Taheri, S ; Sharif University of Technology
    Taylor and Francis Ltd 
    Abstract
    Sulfur Mustard (SM) is a potent alkylating agent and its effects on cells and tissues are varied and complex. Due to limitations in the diagnostics of sulfur mustard exposed individuals (SMEIs) by noninvasive approaches, there is a great necessity to develop novel techniques and biomarkers for this condition. We present here the first nuclear magnetic resonance (NMR) and gas chromatography-mass spectrometry (GC/MS) metabolic profiling of serum from and healthy controls to identify novel biomarkers in blood serum for better diagnostics. Of note, SMEIs were exposed to SM 30 years ago and that differences between two groups could still be found. Pathways in which differences between SMEIs and... 

    Urine and serum NMR-based metabolomics in pre-procedural prediction of contrast-induced nephropathy

    , Article Internal and Emergency Medicine ; Volume 15, Issue 1 , 2020 , Pages 95-103 Dalili, N ; Chashmniam, S ; Khoormizi, S. M. H ; Salehi, L ; Jamalian, S. A ; Nafar, M ; Kalantari, S ; Sharif University of Technology
    Springer  2020
    Abstract
    Contrast induced nephropathy (CIN) has been reported to be the third foremost cause of acute renal failure. Metabolomics is a robust technique that has been used to identify potential biomarkers for the prediction of renal damage. We aim to analyze the serum and urine metabolites changes, before and after using contrast for coronary angiography, to determine if metabolomics can predict early development of CIN. 66 patients undergoing elective coronary angiography were eligible for enrollment. Urine and serum samples were collected prior to administration of CM and 72 h post procedure and analyzed by nuclear magnetic resonance. The significant differential metabolites between patients who... 

    A metabonomics study on crohn's disease using nuclear magnetic resonance spectroscopy

    , Article HealthMED ; Volume 6, Issue 11 , July , 2012 , Pages 3577-3583 ; 18402291 (ISSN) Fathi, F ; Kyani, A ; Nejad, M. R ; Rezaye Tavirani, M ; Naderi, N ; Zali, M. R ; Tafazzoli, M ; Oskouie, A. A ; Sharif University of Technology
    2012
    Abstract
    Objective: Crohn's disease (CD) is one the important illnesses can affect any part of the gastrointestinal tract. CD is not easily diagnosed using the clinical tests. Thus, the discovery of proper methods would be a major step towards CD diagnosis. The aim of this study was to seek the metabolic biomarkers causes of CD compare to control group. Materials and Methods: In present study, we employed metabolic profiling using proton nuclear magnetic resonance spectroscopy (1HNMR) to find metabolites in serum which are helpful for the diagnosis of CD. Classification of CD and healthy subject was done using classification and regression trees (CART). The metabolites that caused changes in people... 

    Associations of primary and secondary organic aerosols with airway and systemic inflammation in an elderly panel cohort

    , Article Epidemiology ; Volume 21, Issue 6 , 2010 , Pages 892-902 ; 10443983 (ISSN) Delfino, R. J ; Staimer, N ; Tjoa, T ; Arhami, M ; Polidori, A ; Gillen, D. L ; George, S. C ; Shafer, M. M ; Schauer, J. J ; Sioutas, C ; Sharif University of Technology
    2010
    Abstract
    Background: Exposure-response information about particulate air-pollution constituents is needed to protect sensitive populations. Particulate matter <2.5 mm (PM 2.5) components may induce oxidative stress through reactive-oxygen-species generation, including primary organics from combustion sources and secondary organics from photochemically oxidized volatile organic compounds. We evaluated differences in airway versus systemic inflammatory responses to primary versus secondary organic particle components, particle size fractions, and the potential of particles to induce cellular production of reactive oxygen species. Methods: A total of 60 elderly subjects contributed up to 12 weekly... 

    Metabolomics analysis of the saliva in patients with chronic hepatitis b using nuclear magnetic resonance: A pilot study

    , Article Iranian Journal of Basic Medical Sciences ; Volume 22, Issue 9 , 2019 , Pages 1044-1049 ; 20083866 (ISSN) Gilany, K ; Mohamadkhani, A ; Chashmniam, S ; Shahnazari, P ; Amini, M ; Arjmand, B ; Malekzadeh, R ; Nobakht Motlagh Ghoochani, B. F ; Sharif University of Technology
    Mashhad University of Medical Sciences  2019
    Abstract
    Objective(s): Hepatitis B virus infection causes chronic disease such as cirrhosis and hepatocellular carcinoma. The metabolomics investigations have been demonstrated to be related to pathophysiologic mechanisms in many disorders such as hepatitis B infection. The aim of this study was to investigate the saliva metabolic profile of patients with chronic hepatitis B infection and to identify underlying mechanisms as well as potential biomarkers associated with the disease. Materials and Methods: Saliva from 16 healthy subjects and 20 patients with chronic hepatitis B virus were analyzed by nuclear magnetic resonance (NMR). Then, multivariate statistical analysis was performed to identify... 

    The metabolomics signature associated with responsiveness to steroid therapy in focal segmental glomerulosclerosis: A pilot study

    , Article Revista de Investigacion Clinica ; Volume 71, Issue 2 , 2019 , Pages 106-115 ; 00348376 (ISSN) Chashmniam, S ; Kalantari, S ; Nafar, M ; Boroumandnia, N ; Sharif University of Technology
    Instituto Nacional de la Nutricion Salvador Zubiran  2019
    Abstract
    Background: Focal segmental glomerulosclerosis (FSGS) is considered one of the most severe glomerular diseases and around 80% of cases are resistant to steroid treatment. Since a large proportion of steroid-resistant (SR) FSGS patients progress to end-stage renal disease, other therapeutic strategies may benefit this population. However, identification of non-invasive biomarkers to predict this high-risk population is needed. Objective: We aimed to identify the biomarker candidates to distinguish SR from steroid-sensitive (SS) patients using metabolomics approach and to identify the possible molecular mechanism of resistance. Methods: Urine was collected from biopsy-proven FSGS patients... 

    A new postural stability-indicator to predict the level of fear of falling in Parkinson's disease patients

    , Article BioMedical Engineering Online ; Volume 19, Issue 1 , 2020 Pourghayoomi, E ; Behzadipour, S ; Ramezani, M ; Joghataei, M. T ; Shahidi, G. A ; Sharif University of Technology
    BioMed Central  2020
    Abstract
    Background: Fear of falling (FoF) is defined as a lasting concern about falling that causes a person to limit or even stop the daily activities that he/she is capable of. Seventy percent of Parkinson's disease (PD) patients report activity limitations due to FoF. Timely identification of FoF is critical to prevent its additional adverse effects on the quality of life. Self-report questionnaires are commonly used to evaluate the FoF, which may be prone to human error. Objectives: In this study, we attempted to identify a new postural stability-indicator to objectively predict the intensity of FoF and its related behavior(s) in PD patients. Methods: Thirty-eight PD patients participated in the... 

    Cytochrome 4Z1 expression is associated with unfavorable survival in triple-negative breast cancers

    , Article Breast Cancer: Targets and Therapy ; Volume 13 , 2021 , Pages 565-574 ; 11791314 (ISSN) Al Saraireh, Y. M ; Alshammari, F. O. F. O ; Youssef, A. M. M ; Al Tarawneh, F ; Al Sarayreh, S ; Almuhaisen, G. H ; Satari, A. O ; Al Shuneigat, J ; Alrawashdeh, H. M ; Sharif University of Technology
    Dove Medical Press Ltd  2021
    Abstract
    Purpose: Triple-negative breast cancer (TNBC) is characterized by high mortality rate, and its clinical management is difficult and complex. Therefore, there is a need for extensive efforts aimed at accelerating the discovery of novel therapies for TNBC. CYP4Z1 has been implicated in the development of breast cancer. The current study aimed at characterizing the expression of CYP4Z1 on TNBC. Materials and Methods: Using immunohistochemistry, CYP4Z1 expression was evaluated on 122 TNBC samples, four samples of breast cancers expressing ER, PR, and HER-2, and four samples of normal breast tissues. The association between the enzyme and various histopathological features and survival of... 

    Glypican-1 overexpression in different types of breast cancers

    , Article OncoTargets and Therapy ; Volume 14 , 2021 , Pages 4309-4318 ; 11786930 (ISSN) Alshammari, F. O. F. O ; Al Saraireh, Y. M ; Youssef, A. M. M ; Al Sarayra, Y. M ; Alrawashdeh, H. M ; Sharif University of Technology
    Dove Medical Press Ltd  2021
    Abstract
    Purpose: Treatment of metastatic breast cancer patients is challenging and remains a major underlying cause of female mortality. Understanding molecular alterations in tumor development is critical to identify novel biomarkers and targets for cancer diagnosis and therapy. One of the aberrant cancer expressions gaining recent research interest is glypican-1. Several studies reported strong glypican-1 expression in various types of human cancers. However, none of these investigated glypican-1 expression in a large cohort of breast cancer histopathological subtypes. Patients and Methods: Immunohistochemistry was used to assess glypican-1 expression in 220 breast cancer patients and its relation... 

    Short-term effects of particle size fractions on circulating biomarkers of inflammation in a panel of elderly subjects and healthy young adults

    , Article Environmental Pollution ; Volume 223 , 2017 , Pages 695-704 ; 02697491 (ISSN) Hassanvand, M. S ; Naddafi, K ; Kashani, H ; Faridi, S ; Kunzli, N ; Nabizadeh, R ; Momeniha, F ; Gholampour, A ; Arhami, M ; Zare, A ; Pourpak, Z ; Hoseini, M ; Yunesian, M ; Sharif University of Technology
    Abstract
    Systemic inflammation biomarkers have been associated with risk of cardiovascular morbidity and mortality. We aimed to clarify associations of acute exposure to particulate matter (PM10(PM < 10 μm), PM2.5-10(PM 2.5–10 μm), PM2.5(PM < 2.5 μm), PM1-2.5(PM 1–2.5 μm), and PM1 (PM < 1 μm)) with systemic inflammation using panels of elderly subjects and healthy young adults. We followed a panel of 44 nonsmoking elderly subjects living in a retirement home and a panel of 40 healthy young adults living in a school dormitory in Tehran city, Iran from May 2012 to May 2013. Blood biomarkers were measured one every 7–8 weeks and included white blood cells (WBC), high sensitive C-reactive protein... 

    Microfluidic devices with gold thin film channels for chemical and biomedical applications: a review

    , Article Biomedical Microdevices ; Volume 21, Issue 4 , 2019 ; 13872176 (ISSN) Ghasemi Toudeshkchoui, M ; Rabiee, N ; Rabiee, M ; Bagherzadeh, M ; Tahriri, M ; Tayebi, L ; Hamblin, M. R ; Sharif University of Technology
    Springer New York LLC  2019
    Abstract
    Microfluidic systems (MFS) provide a range of advantages in biomedical applications, including improved controllability of material characteristics and lower consumption of reagents, energy, time and money. Fabrication of MFS employs various materials, such as glass, silicon, ceramics, paper, and metals such as gold, copper, aluminum, chromium and titanium. In this review, gold thin film microfluidic channels (GTFMFC) are discussed with reference to fabrication methods and their diverse use in chemical and biomedical applications. The advantages of gold thin films (GTF) include flexibility, ease of manufacture, adhesion to polymer surfaces, chemical stability, good electrical conductivity,... 

    Metabolomic biomarkers in the diagnosis of non-alcoholic fatty liver disease

    , Article Hepatitis Monthly ; Volume 19, Issue 9 , 2019 ; 1735143X (ISSN) Chashmniam, S ; Ghafourpour, M ; Rezaei Farimani, A ; Gholami, A ; Nobakht Motlagh Ghoochani, B. F ; Sharif University of Technology
    Kowsar Medical Publishing Company  2019
    Abstract
    Background: Nonalcoholic fatty liver disease (NAFLD) is the most abundant chronic liver disorder, because racial and ethnic differences may influence prevalence and severity of NAFLD. Objectives: This metabolomic study was conducted to identify the metabolic biomarkers and determine the mechanism of progress of NAFLD in Iranian patients. Methods: Serum samples were collected from 75 participants (37 healthy controls and 38 patients with NAFLD) after an overnight fast. The metabolome of all samples were determined by nuclear magnetic resonance (NMR) and were compared by multivariate statistical analysis. Results: Totally, 19 metabolomic biomarkers were identified by NMR. Compared to healthy... 

    Fabrication, modeling and optimization of lyophilized advanced platelet rich fibrin in combination with collagen-chitosan as a guided bone regeneration membrane

    , Article International Journal of Biological Macromolecules ; Volume 125 , 2019 , Pages 383-391 ; 01418130 (ISSN) Ansarizadeh, M ; Mashayekhan, S ; Saadatmand, M ; Sharif University of Technology
    Elsevier B.V  2019
    Abstract
    In this study, lyophilized advanced platelet rich fibrin (A-PRF) was used in combination with collagen-chitosan membrane for the first time to combine advantages of both collagen and A-PRF membranes. Response surface methodology (RSM) was used to design the experimental condition and to correlate the effects of parameters, including chitosan/collagen (chit/col) weight ratio and A-PRF concentration on Young's modulus, mesenchymal stem cell (MSCs) viability and degradation rate of the membranes. Results showed that Young's modulus of the membranes was intensified by increasing chit/col weight ratio and decreasing A-PRF concentration from 3 to 8 MPa. Cell viability of MSCs was improved by both...