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    Fabrication and evaluation of chitosan/gelatin/PVA hydrogel incorporating honey for wound healing applications: An in vitro, in vivo study

    , Article International Journal of Pharmaceutics ; 2020 Shamloo, A ; Aghababaie, Z ; Afjoul, H ; Jami, M ; Bidgoli, M. R ; Vossoughi, M ; Ramazani, A ; Kamyabhesari, K ; Sharif University of Technology
    Elsevier B.V  2020
    Abstract
    In this study, physically cross-linked hydrogels were developed by freezing-thawing method while different concentrations of honey were included into the hydrogels for accelerated wound healing. The hydrogel was composed of chitosan, polyvinyl alcohol (PVA), and gelatin with the ratio of 2:1:1 (v/v), respectively. Further, the effect of honey concentrations on antibacterial properties, and cell behavior was investigated. In vivo studies, including wound healing mechanism using rat model and histological analysis of section tissue samples were performed. The results illustrated that the incorporation of honey in hydrogels increased the ultimate strain of hydrogels approximately two times,... 

    Glass-ceramics for cancer treatment: So close, or yet so far?

    , Article Acta Biomaterialia ; 2018 ; 17427061 (ISSN) Miola, M ; Pakzad, Y ; Banijamali, S ; Kargozar, S ; Vitale Brovarone, C ; Yazdanpanah, A ; Bretcanu, O ; Ramedani, A ; Vernè, E ; Mozafari, M ; Sharif University of Technology
    Abstract
    After years of research on the ability of glass-ceramics in bone regeneration, this family of biomaterials has shown revolutionary potentials in a couple of emerging applications such as cancer treatment. Although glass-ceramics have not yet reached their actual potential in cancer therapy, the relevant research activity is significantly growing in this field. It has been projected that this idea and the advent of magnetic bioactive glass-ceramics and mesoporous bioactive glasses could result in major future developments in the field of cancer. Undoubtedly, this strategy needs further developments to better answer the critical questions essential for clinical usage. This review aims to... 

    Effect of zirconia nanotube coating on the hydrophilicity and mechanochemical behavior of zirconium for biomedical applications

    , Article Surfaces and Interfaces ; Volume 28 , 2022 ; 24680230 (ISSN) Zal Nezhad, E ; Sarraf, M ; Musharavati, F ; Jaber, F ; Wang, J. I ; Hosseini, H. R. M ; Bae, S ; Chowdhury, M ; So, H ; Sukiman, N. L ; Sharif University of Technology
    Elsevier B.V  2022
    Abstract
    Zirconium has attracted considerable attention in the biomedical field owing to its biocompatibility and desirable tribological and mechanical properties. In this study, we anodized pure zirconium in an ammonium fluoride and ethylene glycol electrolyte, which produced a coating of ZrO2 nanotubes (NTs). The ZrO2 coated samples were annealed at different temperatures, and the morphology and structure of the coated substrates were studied using XPS, SEM, TEM, EDS, and SAED. The micro/nanomechanical properties and corrosion resistance of the samples were evaluated. Wear tests performed on bare and coated substrates revealed that the coated samples annealed at 400 °C had a significantly lower... 

    Manufacturing of hydrogel biomaterials with controlled mechanical properties for tissue engineering applications

    , Article Acta Biomaterialia ; Volume 62 , 2017 , Pages 42-63 ; 17427061 (ISSN) Vedadghavami, A ; Minooei, F ; Mohammadi, M. H ; Khetani, S ; Rezaei Kolahchi, A ; Mashayekhan, S ; Sanati Nezhad, A ; Sharif University of Technology
    Abstract
    Hydrogels have been recognized as crucial biomaterials in the field of tissue engineering, regenerative medicine, and drug delivery applications due to their specific characteristics. These biomaterials benefit from retaining a large amount of water, effective mass transfer, similarity to natural tissues and the ability to form different shapes. However, having relatively poor mechanical properties is a limiting factor associated with hydrogel biomaterials. Controlling the biomechanical properties of hydrogels is of paramount importance. In this work, firstly, mechanical characteristics of hydrogels and methods employed for characterizing these properties are explored. Subsequently, the most... 

    Electrically conductive carbon-based (bio)-nanomaterials for cardiac tissue engineering

    , Article Bioengineering and Translational Medicine ; 2022 ; 23806761 (ISSN) Jalilinejad, N ; Rabiee, M ; Baheiraei, N ; Ghahremanzadeh, R ; Salarian, R ; Rabiee, N ; Akhavan, O ; Zarrintaj, P ; Hejna, A ; Saeb, M. R ; Zarrabi, A ; Sharifi, E ; Yousefiasl, S ; Zare, E. N ; Sharif University of Technology
    John Wiley and Sons Inc  2022
    Abstract
    A proper self-regenerating capability is lacking in human cardiac tissue which along with the alarming rate of deaths associated with cardiovascular disorders makes tissue engineering critical. Novel approaches are now being investigated in order to speedily overcome the challenges in this path. Tissue engineering has been revolutionized by the advent of nanomaterials, and later by the application of carbon-based nanomaterials because of their exceptional variable functionality, conductivity, and mechanical properties. Electrically conductive biomaterials used as cell bearers provide the tissue with an appropriate microenvironment for the specific seeded cells as substrates for the sake of... 

    Evaluation of Porous NTI SMA Formation Mechanism, Pore Characteristics and Thermo-Mechanical Properties Produced by Power Metallurgy for Biomedical Application

    , M.Sc. Thesis Sharif University of Technology Ghasemi, Abbas (Author) ; Sadrnezhad, Khatiboleslam (Supervisor)
    Abstract
    Porous NiTi specimens were produced by elemental nickel and titanium powders and two different temporary space-holder consisting of NaCl and urea and conventional sintering method. Pore characteristic and morphology of porous NiTi specimens was investigated by optical and electron microscopy. Microstructure of specimens was probed using XRD and SEM. Suitable pore distribution and size for biomedical application was obtained using temporary space-holder method. Porosity content increases with increasing space holder powder. At 70 volume percent space-holder, best pore size and distribution with fully open pores, in size 200-500 µm, was obtained and pores are interconnected that suitable for... 

    “ Nano Oxide Layer Forming on the Surface of Porous Nitinol Shape Memory Alloy for Improving Surface Properties “

    , M.Sc. Thesis Sharif University of Technology Fattahzadeh, Mehrdad (Author) ; Sadrnejhad, Khatiboleslam (Supervisor)
    Abstract
    In this project ,it has been done different surface treatment on 6 samples of nitinol with 40 % prosity,three of them are anodized by H2SO4 ,Hf, Acetic acid, one of them is treated with plasma spray with TIO2 powder, one of them is putted in the furnace at 700 degrees for an hour, and the last one is bare ; Moreover, these treated samples are putted in Simulated body fluid for 16 days . After this period of time, we analyzed the results. Then the cell adhesion amount of osteo blast cells (MG 63) is measured to these samples by immersing them for 3 days in these cells.The results are investigated by SEM ,XRD(X pertpro produced by Panalitical), XRF(530-XRF-01), AAS( AA240), Roughness measuring... 

    The Effect of Thyroid Hormones on The Viscoelastic Behavior of Red Blood Cells

    , M.Sc. Thesis Sharif University of Technology Laktarash, Shaghayegh (Author) ; Seyed Reihani, Nader (Supervisor)
    Abstract
    Blood is one of the most important fluids in the human body, consisting of three parts: red blood cells, white blood cells and platelets. The mechanical properties of red blood cells are important in many diseases. The study of viscosity and other mechanical properties of red blood cells in recent years has attracted the attention of scientists in this field. The mechanical properties of red blood cells are related to the outer membrane and its cytoskeleton, and the study of these components can predict the behavior of red blood cells in diseases. The thyroid gland is located in front of the neck and secretes hormones that control many chemical processes in different parts of the body.... 

    Effects of polydimethylsiloxane grafting on the calcification, physical properties, and biocompatibility of polyurethane in a heart valve

    , Article Journal of Applied Polymer Science ; Volume 98, Issue 2 , 2005 , Pages 758-766 ; 00218995 (ISSN) Dabagh, M ; Abdekhodaie, M. J ; Khorasani, M. T ; Sharif University of Technology
    2005
    Abstract
    Segmented polyurethane (PU) has proven to be the best biomaterial for artificial heart valves, but the calcification of polyurethane surfaces causes serious problems in long-term implants. This work was undertaken to evaluate the effects of polydimethylsiloxane (PDMS) grafting on the calcification, biocompatibility, and blood compatibility of polyurethane. A grafted polyurethane film was compared with virgin polyurethane surfaces. Physical properties of the samples were examined using different techniques. The hydrophobicity of the polyurethane films increased as a result of silicone modification. The effects of surface modification of polyurethane films on their calcification and fibroblast... 

    Methods for biomaterials printing: A short review and perspective

    , Article Methods ; Volume 206 , 2022 , Pages 1-7 ; 10462023 (ISSN) Shokrani, H ; Shokrani, A ; Saeb, M. R ; Sharif University of Technology
    Academic Press Inc  2022
    Abstract
    Printing technologies have opened larger windows of innovation and creativity to biomaterials engineers by providing them with the ability to fabricate complex shapes in a reasonable time, cost, and weight. However, there has always been a trouble with function adjusting in printing technologies in view of the multiplicity of materials and apparatus parameters. 3D printing, also known as additive manufacturing, revolutionized biomaterials engineering by the conversion of a digital subject into a printed object (implants, scaffolds, or diagnostics and drug delivery devices/systems). Inspired by the lessons learned from 3D printing, the concept of 4D printing (better called shape-morphing... 

    Synthesis and Characterization of Properties of Hybrid Nanoparticles of Gold-graphene

    , M.Sc. Thesis Sharif University of Technology Akhoondi, Soheila (Author) ; Simchi, Abdolreza (Supervisor)
    Abstract
    In recent years utilization of quantum dots for stem cells detection and clean energy production has received intensive attention. Graphene and its derivatives have been widely studied because of their effectiveness on electronical and optoelectronical devices, chemical sensors, nanocomposites, and energy storage. By use of metal nanoparticles, such as AuNPs, we can develop properties of graphene, and control them via shifting the absorption peak wavelength and increasing its biocompatibility. In this research, hybrid nanoparticles of gold-graphene as core-shell and conjugated by polymeric linkers containing amine or thiol functions are synthesized. Our purpose is stabilization the... 

    Experimental Study of Nano-bio Material Injection for Heavy Oil Recovery in Shaly Systems Using Micro-model Apparatus

    , M.Sc. Thesis Sharif University of Technology Mohebbifar, Mahdi (Author) ; Vossoughi, Manouchehr (Supervisor) ; Ghazanfari, Mohammad Hossein (Co-Advisor)
    Abstract
    In this research we aim to find enhance oil recovery mechanisms involved in nano-bio material injection by micro model apparatus which has not been studied before. Especially for injection in heavy oil and shaly porous media that forms most of heavy oil reservoirs. To this end, microscopic images from injection of nano-bio materials to shaly patterns have been taken and analyzed to find the process mechanism. Also amount of enhance oil recovery in different conditions like type of microbe forming bio material, nano-bio material concentration and type of flow pattern (shale characteristics including length, direction and distance from injection and production wells) will be studied.Three... 

    Designing Polymeric Biomaterials based on Polysaccharides with Tissue Adhesion and Hemostasis Performance

    , M.Sc. Thesis Sharif University of Technology Shokrani, Hanieh (Author) ; Mashayekhan, Shohreh (Supervisor) ; Kordzadeh, Azadeh (Co-Supervisor)
    Abstract
    Death can be the result of severe bleeding which is associated with the loss of a high amount of blood like what happens in accidents, wars, or operations. Classic methods to stop bleeding are mostly ineffective to decrease the hemostasis time and the volume of the lost blood. A wide variety of products like powders, foams, and hydrogels have been designed and synthesized either from natural or synthetic polymers. However, limitations like weak tissue adhesion, creating a moist environment in the wound site, infection, weak biodegradation, and hemolysis still have remained. Among the existing options to be used as hemostasis agents, polysaccharides can be appropriate considering their great... 

    Integrative Utilization of Microenvironments, Biomaterials and Computational Techniques for Advanced Tissue Engineering

    , Article Journal of Biotechnology ; Volume 212 , 2015 , Pages 71-89 ; 01681656 (ISSN) Shamloo, A ; Mohammadaliha, N ; Mohseni, M ; Sharif University of Technology
    Elsevier  2015
    Abstract
    This review aims to propose the integrative implementation of microfluidic devices, biomaterials, and computational methods that can lead to a significant progress in tissue engineering and regenerative medicine researches. Simultaneous implementation of multiple techniques can be very helpful in addressing biological processes. Providing controllable biochemical and biomechanical cues within artificial extracellular matrix similar to in vivo conditions is crucial in tissue engineering and regenerative medicine researches. Microfluidic devices provide precise spatial and temporal control over cell microenvironment. Moreover, generation of accurate and controllable spatial and temporal... 

    Experimental investigation of nano-biomaterial applications for heavy oil recovery in shaly porous models: A pore-level study

    , Article Journal of Energy Resources Technology, Transactions of the ASME ; Volume 137, Issue 1 , August , 2014 ; 01950738 (ISSN) Mohebbifar, M ; Ghazanfari, M. H ; Vossoughi, M ; Sharif University of Technology
    American Society of Mechanical Engineers (ASME)  2014
    Abstract
    Application of nano or biomaterials for enhanced oil recovery (EOR) has been recently much attended by petroleum engineering researchers. However, how would be the displacement mechanisms and how would change the recovery efficiency while nano and biomaterials are used simultaneously is still an open question. To this end, a series of injection tests performed on micromodel containing shale strikes. Three types of biomaterials including biosurfactant, bioemulsifier, and biopolymer beside two types of nanoparticles including SiO2 and TiO2 at different concentrations were used as injection fluids. The microscopic as well as macroscopic efficiency of displacements were observed from analysis of... 

    Antibacterial Ti–Cu implants: A critical review on mechanisms of action

    , Article Materials Today Bio ; Volume 17 , 2022 ; 25900064 (ISSN) Mahmoudi, P ; Akbarpour, M. R ; Lakeh, H. B ; Jing, F ; Hadidi, M. R ; Akhavan, B ; Sharif University of Technology
    Elsevier B.V  2022
    Abstract
    Titanium (Ti) has been widely used for manufacturing of bone implants because of its mechanical properties, biological compatibility, and favorable corrosion resistance in biological environments. However, Ti implants are prone to infection (peri-implantitis) by bacteria which in extreme cases necessitate painful and costly revision surgeries. An emerging, viable solution for this problem is to use copper (Cu) as an antibacterial agent in the alloying system of Ti. The addition of copper provides excellent antibacterial activities, but the underpinning mechanisms are still obscure. This review sheds light on such mechanisms and reviews how incorporation of Cu can render Ti–Cu implants with... 

    Design and Optimization of Channeled Hydrogel Scaffold Based on Extracellular Matrix of Heart Tissue with Oxygen Release Capability

    , M.Sc. Thesis Sharif University of Technology Ghasemi, Sara (Author) ; Mashayekhan, Shohreh (Supervisor) ; Khorshidi, Sajedeh (Co-Supervisor)
    Abstract
    Despite the increase in the number of cardiovascular diseases worldwide, the number of new drugs to treat these diseases has been decreasing in the last decade. Current preclinical drug evaluation strategies, which use cell cultures and oversimplified animal models, cannot meet the growing demand for new and effective drugs. In the last decade, the development of microfluidic bioreactors and organ-on-chip systems to improve the drug screening process has been increasing significantly. These systems have shown many advantages over previous preclinical models. Despite all these advantages, keeping the oxygen concentration at the optimal physiological level in microfluidic systems has its own... 

    Microstructure, mechanical properties, corrosion behavior and cytotoxicity of Mg-Zn-Al-Ca alloys as biodegradable materials

    , Article Journal of Alloys and Compounds ; Vol. 607 , 2014 , Pages 1-10 ; ISSN: 09258388 Homayun, B ; Afshar, A ; Sharif University of Technology
    Abstract
    Recently, considerable attentions have been paid to alloy Mg-4Zn-0.2Ca for biomedical applications due to its suitable biocompatibility and acceptable mechanical properties. In this work, the effects of the addition of different amounts of Al on microstructure, mechanical properties, degradation behavior, and biocompatibility of this alloy were investigated. The corrosion behaviors of the alloys were investigated through polarization tests, chronoamperometry analysis, immersion tests, and EIS experiments. The mechanical properties were analyzed by using tensile tests and compression tests. The results showed that the addition of Al up to 3 wt.% considerably modifies the degradation behaviors... 

    State of the art review on design and manufacture of hybrid biomedical materials: Hip and knee prostheses

    , Article Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine ; Volume 231, Issue 9 , 2017 , Pages 785-813 ; 09544119 (ISSN) Bahraminasab, M ; Farahmand, F ; Sharif University of Technology
    Abstract
    The trend in biomaterials development has now headed for tailoring the properties and making hybrid materials to achieve the optimal performance metrics in a product. Modern manufacturing processes along with advanced computational techniques enable systematical fabrication of new biomaterials by design strategy. Functionally graded materials as a recent group of hybrid materials have found numerous applications in biomedical area, particularly for making orthopedic prostheses. This article, therefore, seeks to address the following research questions: (RQ1) What is the desired structure of orthopedic hybrid materials? (RQ2) What is the contribution of the literature in the development of... 

    Development of a genetic algorithm based biomechanical simulation of sagittal lifting tasks

    , Article Biomedical Engineering - Applications, Basis and Communications ; Volume 17, Issue 1 , 2005 , Pages 12-18 ; 10162372 (ISSN) Gündoǧdu, Ö ; Anderson, K. S ; Parnianpour, M ; Sharif University of Technology
    Institute of Biomedical Engineering  2005
    Abstract
    Fibrin sealant and platelet gels are human blood-derived, biodegradable, non toxic, surgical products obtained by mixing a fibrinogen concentrate or a platelet rich plasma with thrombin, respectively. Fibrin sealant is now a well known surgical tool increasingly used to stop or control bleeding, or to provide air and fluid tightness in many surgical situations. Platelet gels are newly developed preparations that are of specific interest because they contain numerous physiological growth factors and cytikines that are released upon the activation of blood platelets by thrombin. These growth factors, including PDGF, TGF-β1, BMP, and VEGF have been shown to stimulate cell growth and...