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biomedical-microelectromechanical-system--bio-mems
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Separation and Microfluidic Analysis of one Cancer Biomarker (Exosome) by Means of Microfluidic Chip Microfluidc Analysis Exosome Toward Liquid Biopsy for Cancer Tumor Cell
, M.Sc. Thesis Sharif University of Technology ; Saidi, Mohammad Said (Supervisor) ; Firouzabadi, Bahar (Co-Supervisor)
Abstract
The recent breakthroughs in the lab-on-a-chip technology will not be directly used as clinical devices unless the specific applications are carefully tested and certified. As there is a growing trend towards microfluidic devices for biomedical research, an active microfluidic device was developed. Common microfabrication methods were used to develop a microchip to separate and concentrate exosome and particular cell based on the dielectrophoresis phenomenon. Unique capabilities of the dielectrophoresis phenomenon make it a powerful tool for micro particle manipulation in micro scale. In this research, geometry for the mentioned purpose is designed and optimized. Three-dimensional...
Dynamics of Magnetic Nanoparticles in Biologically Inspired Flows under Effect of Electric and Magnetic Fields with Application in Epilepsy Detection
, Ph.D. Dissertation Sharif University of Technology ; Alasty, Aria (Supervisor) ; Ghaffarzadeh, Ebrahim (Supervisor) ; Shamloo, Amir (Co-Advisor)
Abstract
This thesis presents my Ph.D. research study focusing on the dynamic analysis of magnetic nanoparticles (MNPs) for epilepsy and blood-brain barrier (BBB) applications. In this analysis, we took into account various parameters including the magnetic field, fluid behavior, geometry and material of MNPs. Based on this computational study, the generated magnetic field in epileptic foci results in the aggregation of nanoparticles. This may offer the advantage of using MNPs as a Magnetic Resonance Imaging (MRI) contrast agent. Furthermore, in this study, we also demonstrated and discussed the advantage of MNPs for crossing BBB using the external magnetic field. The outcome of this research project...