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    Secondary flows, mixing, and chemical reaction analysis of droplet-based flow inside serpentine microchannels with different cross sections

    , Article Langmuir ; Volume 37, Issue 17 , 2021 , Pages 5118-5130 ; 07437463 (ISSN) Ghazimirsaeed, E ; Madadelahi, M ; Dizani, M ; Shamloo, A ; Sharif University of Technology
    American Chemical Society  2021
    Abstract
    Chemical bioreactions are an important aspect of many recent microfluidic devices, and their applications in biomedical science have been growing worldwide. Droplet-based microreactors are among the attractive types of unit operations, which utilize droplets for enhancement in both mixing and chemical reactions. In the present study, a finite-volume-method (FVM) numerical investigation is conducted based on the volume-of-fluid (VOF) applying for the droplet-based flows. This multiphase computational modeling is used for the study of the chemical reaction and mixing phenomenon inside a serpentine microchannel and explores the effects of the aspect ratio (i.e., AR = height/width) of... 

    Metal–organic frameworks (MOFs) for cancer therapy

    , Article Materials ; Volume 14, Issue 23 , 2021 ; 19961944 (ISSN) Saeb, M. R ; Rabiee, N ; Mozafari, M ; Verpoort, F ; Voskressensky, L. G ; Luque, R ; Sharif University of Technology
    MDPI  2021
    Abstract
    MOFs exhibit inherent extraordinary features for diverse applications ranging from cataly-sis, storage, and optics to chemosensory and biomedical science and technology. Several procedures including solvothermal, hydrothermal, mechanochemical, electrochemical, and ultrasound techniques have been used to synthesize MOFs with tailored features. A continued attempt has also been directed towards functionalizing MOFs via “post-synthetic modification” mainly by changing linkers (by altering the type, length, functionality, and charge of the linkers) or node components within the MOF framework. Additionally, efforts are aimed towards manipulating the size and morphology of crystallite domains in... 

    Recent advances in the modification of carbon-based quantum dots for biomedical applications

    , Article Materials Science and Engineering C ; Volume 120 , 2021 ; 09284931 (ISSN) Alaghmandfard, A ; Sedighi, O ; Tabatabaei Rezaei, N ; Abedini, A. A ; Malek Khachatourian, A ; Toprak, M. S ; Seifalian, A ; Sharif University of Technology
    Elsevier Ltd  2021
    Abstract
    Carbon-based quantum dots (CDs) are mainly divided into two sub-groups; carbon quantum dots (CQDs) and graphene quantum dots (GQDs), which exhibit outstanding photoluminescence (PL) properties, low toxicity, superior biocompatibility and facile functionalization. Regarding these features, they have been promising candidates for biomedical science and engineering applications. In this work, we reviewed the efforts made to modify these zero-dimensional nano-materials to obtain the best properties for bio-imaging, drug and gene delivery, cancer therapy, and bio-sensor applications. Five main surface modification techniques with outstanding results are investigated, including doping, surface... 

    Recent advances in the modification of carbon-based quantum dots for biomedical applications

    , Article Materials Science and Engineering C ; Volume 120 , 2021 ; 09284931 (ISSN) Alaghmandfard, A ; Sedighi, O ; Tabatabaei Rezaei, N ; Abedini, A. A ; Malek Khachatourian, A ; Toprak, M. S ; Seifalian, A ; Sharif University of Technology
    Elsevier Ltd  2021
    Abstract
    Carbon-based quantum dots (CDs) are mainly divided into two sub-groups; carbon quantum dots (CQDs) and graphene quantum dots (GQDs), which exhibit outstanding photoluminescence (PL) properties, low toxicity, superior biocompatibility and facile functionalization. Regarding these features, they have been promising candidates for biomedical science and engineering applications. In this work, we reviewed the efforts made to modify these zero-dimensional nano-materials to obtain the best properties for bio-imaging, drug and gene delivery, cancer therapy, and bio-sensor applications. Five main surface modification techniques with outstanding results are investigated, including doping, surface...