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    A hepatocellular carcinoma–bone metastasis-on-a-chip model for studying thymoquinone-loaded anticancer nanoparticles

    , Article Bio-Design and Manufacturing ; Volume 3, Issue 3 , 2020 , Pages 189-202 Sharifi, F ; Yesil Celiktas, O ; Kazan, A ; Maharjan, S ; Saghazadeh, S ; Firoozbakhsh, K ; Firoozabadi, B ; Zhang, Y. S ; Sharif University of Technology
    Springer  2020
    We report the development of a metastasis-on-a-chip platform to model and track hepatocellular carcinoma (HCC)–bone metastasis and to analyze the inhibitory effect of an herb-based compound, thymoquinone (TQ), in hindering the migration of liver cancer cells into the bone compartment. The bioreactor consisted of two chambers, one accommodating encapsulated HepG2 cells and one bone-mimetic niche containing hydroxyapatite (HAp). Above these chambers, a microporous membrane was placed to resemble the vascular barrier, where medium was circulated over the membrane. It was observed that the liver cancer cells proliferated inside the tumor microtissue and disseminated from the HCC chamber to the... 

    Kinetics of organic removal in fixed-bed aerobic biological reactor

    , Article Bioresource Technology ; Volume 99, Issue 5 , 2008 , Pages 1118-1124 ; 09608524 (ISSN) Borghei, S. M ; Sharbatmaleki, M ; Pourrezaie, P ; Borghei, G ; Sharif University of Technology
    The process kinetics of a lab-scale upflow aerobic immobilized biomass (UAIB) reactor using simulated sugar-manufacturing wastewater as feed was investigated. The experimental unit consisted of a 22 l reactor filled with high porosity pumice stone. The UAIB reactor was tested under different organic loads and different hydraulic retention times (HRT) and the substrate loading removal rate was compared with prediction of Stover-Kincannon model, second-order model and the first order substrate removal model. After obtaining steady-state conditions, organic loading rate was increased from 750 to 4500 g COD/m3 day to resemble wastewater from sugar production lines, and hydraulic retention time... 

    Bio-oxidation of ferrous ions by Acidithioobacillus ferrooxidans in amonolithic bioreactor

    , Article Journal of Chemical Technology and Biotechnology ; Volume 84, Issue 4 , 2009 , Pages 504-510 ; 02682575 (ISSN) Kahrizi, E ; Alemzadeh, I ; Vossoughi, M ; Sharif University of Technology
    Background: The bio-oxidation of ferrous iron is a potential industrial process in the regeneration of ferric iron and the removal of H2S in combustible gases. Bio-oxidation of ferrous iron may be an alternative method of producing ferric sulfate, which is a reagent used for removal of H2S from biogas, tail gas and in the pulp and paper industry. For practical use of this process, this study evaluated the optimal pH and initial ferric concentration. pH control looks like a key factor as it acts both on growth rate and on solubility ofmaterials in the system. Results: Process variables such as pH and amount of initial ferrous ions on oxidation by A. ferrooxidans and the effects of process...