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Computational modeling of media flow through perfusion-based bioreactors for bone tissue engineering
, Article Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine ; Volume 234, Issue 12 , 2020 , Pages 1397-1408 ; Bohlouli, M ; Adavi, K ; Paknejad, Z ; Rezai Rad, M ; khani, M. M ; Salehi-Nik, N ; Khojasteh, A ; Sharif University of Technology
SAGE Publications Ltd
2020
Abstract
Bioreactor system has been used in bone tissue engineering in order to simulate dynamic nature of bone tissue environments. Perfusion bioreactors have been reported as the most efficient types of shear-loading bioreactor. Also, combination of forces, such as rotation plus perfusion, has been reported to enhance cell growth and osteogenic differentiation. Mathematical modeling using sophisticated infrastructure processes could be helpful and streamline the development of functional grafts by estimating and defining an effective range of bioreactor settings for better augmentation of tissue engineering. This study is aimed to conduct computational modeling for newly designed bioreactors in...