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Design of Nature-Inspired Multicolor Sensor for Detection and Discrimination of Biothiols based on Anti-Etching on Gold Nanorods
, M.Sc. Thesis Sharif University of Technology ; Hormozinezhad, Mohammad Reza (Supervisor)
Abstract
Biological thiols are crucial substances that play an essential role in several biological processes and activities in the body. Hence, the fluctuation of their concentrations can be used as a diagnostic sign for numerous disorders. In contrast, the ratio of these thiols to their disulfide form within the cell is useful as an indicator for determining cytotoxicity. Hence, it is crucial for develop a simple yet efficient analytical technique for quickly recognizing and determining them. The purpose of this study is to develop a plasmonic colorimetric sensor by utilizing gold nanorods (AuNRs). This sensor aims to accurately measure and distinguish between cysteine (CYS) and glutathione (GSH),...
A colorimetric sensor array for detection and discrimination of biothiols based on aggregation of gold nanoparticles
, Article Analytica Chimica Acta ; Volume 882 , July , 2015 , Pages 58-67 ; 00032670 (ISSN) ; Hormozi-Nezhad, M.R ; Mahmoudi, M ; Sharif University of Technology
Elsevier
2015
Abstract
Developments of sensitive, rapid, and cheap systems for identification of a wide range of biomolecules have been recognized as a critical need in the biology field. Here, we introduce a simple colorimetric sensor array for detection of biological thiols, based on aggregation of three types of surface engineered gold nanoparticles (AuNPs). The low-molecular-weight biological thiols show high affinity to the surface of AuNPs; this causes replacement of AuNPs' shells with thiol containing target molecules leading to the aggregation of the AuNPs through intermolecular electrostatic interaction or hydrogen-bonding. As a result of the predetermined aggregation, color and UV-vis spectra of AuNPs...