Sharif Digital Repository

The bladder is one of the most important internal organs of human that improper functioning of this organ causes various diseases such as bladder exstrophy, bladder syndrome, bladder cancer and bladder infection. The main challenge in treating these diseases is the presence of a mucous layer consisting of glycosaminoglysis (GAG) in the bladder wall that prevents drugs from reaching the surface of the bladder. Hence, drug delivery through the mucosal layer is not easy, Hence, urease micro/nano carriers have recently been considered for the treatment of bladder diseases. In this study, new janus micromotors based on black titanium oxide with asymmetric urease catalytic coating were synthesized... 

Enzyme-powered motors self-propel through the catalysis of biofuels, which makes them excellent candidates for biomedical applications. However, fundamental issues such as their movement in biological fluids and understanding the mechanism of propulsion are important aspects that must be considered before application in biomedicine. Building active systems based on biocompatible materials that use non-toxic fuels to power their vehicles have always been challenging. In this study, self-propelled micromotors consist of titanium dioxide black spheres asymmetrically coated with a thin layer of gold. Cysteine was used to bind urease enzyme due to thiol binding. By biocatalytically converting...