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Feasibility Study of Culturing and Differentiating Mesenchymal Stem Cells to Smooth Muscle Cells in Nanostructured PCL Hybrid Scaffold
, M.Sc. Thesis Sharif University of Technology ;
Abstract
Tissue engineering is an interdisciplinary field that incorporates principles of engineering with the life sciences. Tissue engineering consists of three principle; cells, scaffolds for cells expansion and growth factors. These factors together can help tissue engineers to provide appropriate microenvironments for directing special cells behavior.
Fibrous scaffolds have found many applications in tissue engineering due to their nanometer dimensions and high surface to volume ratio. Fibrous scaffolds can impart mechanical strength, structure for cell attachment and act as reservoirs for biomolecule delivery in much a same way as the natural fibrous components of the extracellular...
Fibrous scaffolds have found many applications in tissue engineering due to their nanometer dimensions and high surface to volume ratio. Fibrous scaffolds can impart mechanical strength, structure for cell attachment and act as reservoirs for biomolecule delivery in much a same way as the natural fibrous components of the extracellular...
Design and Construction of PCL Nanofiber Scaffold for Bladder Tissue Engineering
, M.Sc. Thesis Sharif University of Technology ; Yaghmaei, Soheyla (Supervisor) ; Mashayekhan, Shohreh (Co-Advisor)
Abstract
In this project, a novel system of bioactive electrospun scaffold for bladder tissue engineering , has been investigated to control in vitro cell differentiation, and utilize in in vivo vascularization and tissue formation. This method doesn’t have custom bioactive scaffolds problems such as, protein instability, technical complexity and, difficulties in accurate kinetics prediction. First of all, protein loaded chitosan nanoparticles based on ionic gelation interaction between chitosan and Sodium tripolyphosphate were prepared. Maximum protein loading efficiency (80% for BSA & 99% for TGF-beta1) in chitosan nanoparticles was obtained at mean diameter of 51nm. Moreover polycaprolactone...
Effect of Urease on the Motion of Janus Micromotors Based on Black Titanium Dioxide
, M.Sc. Thesis Sharif University of Technology ; Madaah Hosseini, Hamid Reza (Supervisor)
Abstract
The bladder is one of the most important internal organs of human that improper functioning of this organ causes various diseases such as bladder exstrophy, bladder syndrome, bladder cancer and bladder infection. The main challenge in treating these diseases is the presence of a mucous layer consisting of glycosaminoglysis (GAG) in the bladder wall that prevents drugs from reaching the surface of the bladder. Hence, drug delivery through the mucosal layer is not easy, Hence, urease micro/nano carriers have recently been considered for the treatment of bladder diseases. In this study, new janus micromotors based on black titanium oxide with asymmetric urease catalytic coating were synthesized...
Design and fabrication of a new expandable transtibial liner with manual volume control: A prototype
, Article Journal of Biomedical Physics and Engineering ; Volume 10, Issue 4 , 2020 , Pages 543-548 ; Aminian, G ; Farahmand, F ; Rahgozar, M ; Sharif University of Technology
Shiraz University of Medical Sciences
2020
Abstract
Diurnal volume changes is one of the main factors influencing socket fit in trans-tibial prosthesis and causing pressure problem issues. Embedded bladder liners have been recently a potential approach to deal with this problem. The aim of this technical note was to introduce a new transtibial silicone liner designed based on hybrid socket theory. To make expandability in the liner, an integrated wax structure was constructed over the selected areas of the positive model and then removed after lamination process. In addition, a mechanical system with manual control was designed to fit the liner with the residual limb volume by pumping the water in or out of the liner through connec-tive...
Mechanical reinforcement of urinary bladder matrix by electrospun polycaprolactone nanofibers
, Article Scientia Iranica ; Volume 24, Issue 6 , 2017 , Pages 3476-3480 ; 10263098 (ISSN) ; Rajabi Zeleti, S ; Naji, M ; Ghanian, M. H ; Baharvand, H ; Sharif University of Technology
Abstract
For a successful repair and reconstruction of bladder tissue, fabrication of scaffolds with proper biochemical and biomechanical characteristics is necessary. Decellularized bladder tissue has been proposed in previous studies as a gold standard material for scaffold fabrication. However, weak mechanical properties of such a load-bearing tissue has remained a challenge. Incorporation of both biological and synthetic materials has been known as an effective strategy for improving mechanical and biological properties of the scaffolds. In the present work, a simple process was developed to fabricate hybrid hydrogel scaffolds with a biomimetic architecture from the natural urinary bladder...
The synergistic effect of surface topography and sustained release of TGF-β1 on myogenic differentiation of human mesenchymal stem cells
, Article Journal of Biomedical Materials Research - Part A ; Volume 104, Issue 7 , 2016 , Pages 1610-1621 ; 15493296 (ISSN) ; Mashayekhan, S ; Vakilian, S ; Ardeshirylajimi, A ; Soleimani, M ; Sharif University of Technology
John Wiley and Sons Inc
Abstract
A combination of topographical cues and controlled release of biochemical factors is a potential platform in controlling stem cells differentiation. In this study the synergistic effect of nanotopography and sustained release of biofunctional transforming growth factor beta 1 (TGF-β1) on differentiation of human Wharton's Jelly-derived mesenchymal stem cell (hWJ-derived UC-MSCs) toward myogenic lineage was investigated. In order to achieve a sustained release of TGF-β1, this factor was encapsulated within chitosan nanoparticles. Afterwards the aligned composite mats were fabricated using poly-E-caprolacton (PCL) containing TGF-β1-loaded chitosan nanoparticles and poly-L-lactic acid (PLLA)....
Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 29 cancer groups, 1990 to 2017: a systematic analysis for the global burden of disease study
, Article JAMA Oncology ; Volume 5, Issue 12 , 2019 , Pages 1749-1768 ; 23742437 (ISSN) ; Abate, D ; Abbasi, N ; Abbastabar, H ; Abd Allah, F ; Abdel Rahman, O ; Abdelalim, A ; Abdoli, A ; Abdollahpour, I ; Abdulle, A. S. M ; Abebe, N. D ; Abraha, H. N ; Abu Raddad, L. J ; Abualhasan, A ; Adedeji, I. A ; Advani, S. M ; Afarideh, M ; Afshari, M ; Aghaali, M ; Agius, D ; Agrawal, S ; Ahmadi, A ; Ahmadian, E ; Ahmadpour, E ; Ahmed, M. B ; Akbari, M. E ; Akinyemiju, T ; Al Aly, Z ; Alabdulkader, A. M ; Alahdab, F ; Alam, T ; Alamene, G. M ; Alemnew, B. T. T ; Alene, K. A ; Alinia, C ; Alipour, V ; Aljunid, S. M ; Bakeshei, F. A ; Almadi, M. A. H ; Almasi Hashiani, A ; Alsharif, U ; Alsowaidi, S ; Alvis Guzman, N ; Amini, E ; Amini, S ; Amoako, Y. A ; Anbari, Z ; Anber, N. H ; Andrei, C. L ; Anjomshoa, M ; Ansari, F ; Ansariadi, A ; Appiah, S. C. Y ; Arab Zozani, M ; Arabloo, J ; Arefi, Z ; Aremu, O ; Areri, H. A ; Artaman, A ; Asayesh, H ; Asfaw, E. T ; Ashagre, A. F ; Assadi, R ; Ataeinia, B ; Atalay, H. T ; Ataro, Z ; Atique, S ; Ausloos, M ; Avila Burgos, L ; Avokpaho, E. F. G. A ; Awasthi, A ; Awoke, N ; Ayala Quintanilla, B. P ; Ayanore, M. A ; Ayele, H. T ; Babaee, E ; Bacha, U ; Badawi, A ; Bagherzadeh, M ; Bagli, E ; Balakrishnan, S ; Balouchi, A ; Barnighausen, T. W ; Battista, R. J ; Behzadifar, M ; Behzadifar, M ; Bekele, B. B ; Belay, Y. B ; Belayneh, Y. M ; Berfield, K. K. S ; Berhane, A ; Bernabe, E ; Beuran, M ; Bhakta, N ; Bhattacharyya, K ; Biadgo, B ; Bijani, A ; Bin Sayeed, M. S ; Birungi, C ; Bisignano, C ; Bitew, H ; Bjorge, T ; Bleyer, A ; Bogale, K. A ; Bojia, H. A ; Borzi, A. M ; Bosetti, C ; Bou Orm, I. R ; Brenner, H ; Brewer, J. D ; Briko, A. N ; Briko, N. I ; Bustamante-Teixeira, M. T ; Butt, Z. A ; Carreras, G ; Carrero, J. J ; Carvalho, F ; Castro, C ; Castro, F ; Catala Lopez, F ; Cerin, E ; Chaiah, Y ; Chanie, W. F ; Chattu, V. K ; Chaturvedi, P ; Chauhan, N. S ; Chehrazi, M ; Chiang, P. P. C ; Chichiabellu, T. Y ; Chido Amajuoyi, O. G ; Chimed Ochir, O ; Choi, J. Y. J ; Christopher, D. J ; Chu, D. T ; Constantin, M. M ; Costa, V. M ; Crocetti, E ; Crowe, C. S ; Curado, M. P ; Dahlawi, S. M. A ; Damiani, G ; Darwish, A. H ; Daryani, A ; Das Neves, J ; Demeke, F. M ; Demis, A. B ; Demissie, B. W ; Demoz, G. T ; Denova Gutierrez, E ; Derakhshani, A ; Deribe, K. S ; Desai, R ; Desalegn, B. B ; Desta, M ; Dey, S ; Dharmaratne, S. D ; Dhimal, M ; Diaz, D ; Dinberu, M. T. T ; Djalalinia, S ; Doku, D. T ; Drake, T. M ; Dubey, M ; Dubljanin, E ; Duken, E. E ; Ebrahimi, H ; Effiong, A ; Eftekhari, A ; El Sayed, I ; Zaki, M. E. S ; El Jaafary, S. I ; El Khatib, Z ; Elemineh, D. A ; Elkout, H ; Ellenbogen, R. G ; Elsharkawy, A ; Emamian, M. H ; Endalew, D. A ; Endries, A. Y ; Eshrati, B ; Fadhil, I ; Fallah, V ; Faramarzi, M ; Farhangi, M. A ; Farioli, A ; Farzadfar, F ; Fentahun, N ; Fernandes, E ; Feyissa, G. T ; Filip, I ; Fischer, F ; Fisher, J. L ; Force, L. M ; Foroutan, M ; Freitas, M ; Fukumoto, T ; Futran, N. D ; Gallus, S ; Gankpe, F. G ; Gayesa, R. T ; Gebrehiwot, T. T ; Gebremeskel, G. G ; Gedefaw, G. A ; Gelaw, B. K ; Geta, B ; Getachew, S ; Gezae, K. E ; Ghafourifard, M ; Ghajar, A ; Ghashghaee, A ; Gholamian, A ; Gill, P.S ; Ginindza, T. T. G ; Girmay, A ; Gizaw, M ; Gomez, R. S ; Gopalani, S. V ; Gorini, G ; Goulart, B. N. G ; Grada, A ; Ribeiro Guerra, M ; Guimaraes, A.L.S ; Gupta, P. C ; Gupta, R ; Hadkhale, K ; Haj Mirzaian, A ; Hamadeh, R. R ; Hamidi, S ; Hanfore, L. K ; Haro, J. M ; Hasankhani, M ; Hasanzadeh, A ; Hassen, H. Y ; Hay, R. J ; Hay, S. I ; Henok, A ; Henry, N. J ; Herteliu, C ; Hidru, H. D ; Hoang, C. L ; Hole, M. K ; Hoogar, P ; Horita, N ; Hosgood, H. D ; Hosseini, M ; Hosseinzadeh, M ; Hostiuc, M ; Hostiuc, S ; Househ, M ; Hussen, M. M ; Ileanu, B ; Ilic, M.D ; Innos, K ; Irvani, S. S. N ; Iseh, K. R ; Islam, S. M. S ; Islami, F ; Jafari Balalami, N ; Jafarinia, M ; Jahangiry, L ; Jahani, M. A ; Jahanmehr, N ; Jakovljevic, M ; James, S.L ; Javanbakht, M ; Jayaraman, S ; Jee, S. H ; Jenabi, E ; Jha, R. P ; Jonas, J. B ; Jonnagaddala, J ; Joo, T ; Jungari, S. B ; Jurisson, M ; Kabir, A ; Kamangar, F ; Karch, A ; Karimi, N ; Karimian, A ; Kasaeian, A ; Kasahun, G. G ; Kassa, B ; Kassa, T. D ; Kassaw, M. W ; Kaul, A ; Keiyoro, P. N ; Kelbore, A. G ; Kerbo, A. A ; Khader, Y. S ; Khalilarjmandi, M ; Khan, E. A ; Khan, G ; Khang, Y. H ; Khatab, K ; Khater, A ; Khayamzadeh, M ; Khazaee Pool, M ; Khazaei, S ; Khoja, A. T ; Khosravi, M. H ; Khubchandani, J ; Kianipour, N ; Kim, D ; Kim, Y. J ; Kisa, A ; Kisa, S ; Kissimova Skarbek, K ; Komaki, H ; Koyanagi, A ; Krohn, K. J ; Bicer, B. K ; Kugbey, N ; Kumar, V ; Kuupiel, D ; La Vecchia, C ; Lad, D. P ; Lake, E. A ; Lakew, A. M ; Lal, D. K ; Lami, F. H ; Lan, Q ; Lasrado, S ; Lauriola, P ; Lazarus, J. V ; Leigh, J ; Leshargie, C. T ; Liao, Y ; Limenih, M. A ; Listl, S ; Lopez, A. D ; Lopukhov, P. D ; Lunevicius, R ; Madadin, M ; Magdeldin, S ; El Razek, H. M. A ; Majeed, A ; Maleki, A ; Malekzadeh, R ; Manafi, A ; Manafi, N ; Manamo, W. A ; Mansourian, M ; Mansournia, M .A ; Mantovani, L. G ; Maroufizadeh, S ; Martini, S. M. S ; Mashamba Thompson, T. P ; Massenburg, B. B ; Maswabi, M. T ; Mathur, M. R ; McAlinden, C ; McKee, M ; Meheretu, H. A. A ; Mehrotra, R ; Mehta, V ; Meier, T ; Melaku, Y. A ; Meles, G. G ; Meles, H. G ; Melese, A ; Melku, M ; Memiah, P. T. N ; Mendoza, W ; Menezes, R. G ; Merat, S ; Meretoja, T. J ; Mestrovic, T ; Miazgowski, B ; Miazgowski, T ; Mihretie, K. M. M ; Miller, T. R ; Mills, E. J ; Mir, S. M ; Mirzaei, H ; Mirzaei, H. R ; Mishra, R ; Moazen, B ; Mohammad, D. K ; Mohammad, K. A ; Mohammad, Y ; Darwesh, A. M ; Mohammadbeigi, A ; Mohammadi, H ; Mohammadi, M ; Mohammadian, M ; Mohammadian Hafshejani, A ; Mohammadoo Khorasani, M ; Mohammadpourhodki, R ; Mohammed, A. S ; Mohammed, J. A ; Mohammed, S ; Mohebi, F ; Mokdad, A. H ; Monasta, L ; Moodley, Y ; Moosazadeh, M ; Moossavi, M ; Moradi, G ; Moradi Joo, M ; Sharif University of Technology
American Medical Association
2019
Abstract
Importance: Cancer and other noncommunicable diseases (NCDs) are now widely recognized as a threat to global development. The latest United Nations high-level meeting on NCDs reaffirmed this observation and also highlighted the slow progress in meeting the 2011 Political Declaration on the Prevention and Control of Noncommunicable Diseases and the third Sustainable Development Goal. Lack of situational analyses, priority setting, and budgeting have been identified as major obstacles in achieving these goals. All of these have in common that they require information on the local cancer epidemiology. The Global Burden of Disease (GBD) study is uniquely poised to provide these crucial data....