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    Measuring viscoelastic properties of Red Blood Cell using optical tweezers

    , Article Iranian Journal of Physics Research ; Volume 19, Issue 1 , 2019 , Pages 101-108 ; 16826957 (ISSN) Seyed Reihani, S. N ; Azadbakht, A ; Mirzahossein, E ; Mottaghian, M ; Babaei, M ; Sharif University of Technology
    Isfahan University of Technology  2019
    Abstract
    Efforts have been made to study the behavior of complex materials in micrometer dimensions with various techniques. One of these methods is the use of optical tweezers for biophysical applications. Red blood cells, as the most abundant blood-forming cells, play an important role in the life of living organisms, and their unique mechanical properties are important. In this report, the study of soft materials is done using light tweezers. This work investigates micrometer particle movements in the optical trap and also, when they are connected to a red blood cell. The tweezers allow the Newtonian fluid viscosity, such as water and glycerin, to measure the mechanical properties of viscoelastic... 

    Measuring viscoelastic properties of Red Blood Cell using optical tweezers

    , Article Iranian Journal of Physics Research ; Volume 19, Issue 1 , 2019 , Pages 101-108 ; 16826957 (ISSN) Seyed Reihani, S. N ; Azadbakht, A ; Mirzahossein, E ; Mottaghian, M ; Babaei, M ; Sharif University of Technology
    Isfahan University of Technology  2019
    Abstract
    Efforts have been made to study the behavior of complex materials in micrometer dimensions with various techniques. One of these methods is the use of optical tweezers for biophysical applications. Red blood cells, as the most abundant blood-forming cells, play an important role in the life of living organisms, and their unique mechanical properties are important. In this report, the study of soft materials is done using light tweezers. This work investigates micrometer particle movements in the optical trap and also, when they are connected to a red blood cell. The tweezers allow the Newtonian fluid viscosity, such as water and glycerin, to measure the mechanical properties of viscoelastic... 

    Experimental investigation of the roles of blood volume and density in finger photoplethysmography

    , Article IEEE Sensors Journal ; Volume 13, Issue 5 , 2013 , Pages 1397-1398 ; 1530437X (ISSN) Keikhosravi, A ; Zahedi, E ; Attar, H. M ; Aghajani, H ; Sharif University of Technology
    2013
    Abstract
    Using simultaneous photoplethysmogram (PPG) and pulse transducer signals from the same finger, a high correlation (Mean: 98.6, STD: 1) is obtained between the AC part of the PPG and estimated volume changes (after normalization). These results point to the fact that in the resting fingertip, PPG signal variations are only due to volume changes and that blood density does not change thus has no contribution  

    Blood inventory management in hospitals: considering supply and demand uncertainty and blood transshipment possibility

    , Article Operations Research for Health Care ; Volume 15 , 2017 , Pages 43-56 ; 22116923 (ISSN) Najafi, M ; Ahmadi, A ; Zolfagharinia, H ; Sharif University of Technology
    Abstract
    Despite significant advancements in medicine, human blood is still a scarce resource. Only humans produce it, and there is currently no other product or alternative chemical process that can be used to generate blood. For this reason, blood is a vital commodity in healthcare systems. Since blood is also a perishable product, its inventory management is difficult. The challenge is in holding enough stock to ensure a high level of supply while keeping losses from expiration at a minimum. This research will investigate blood inventory management in a hospital, and develop a mathematical model to manage blood ordering and issuing. This study will account for the fact that blood demand and supply... 

    A bi-objective robust optimization model for a blood collection and testing problem: an accelerated stochastic benders decomposition

    , Article Annals of Operations Research ; 2018 ; 02545330 (ISSN) Yousefi Nejad Attari, M ; Pasandideh, S. H. R ; Aghaie, A ; Akhavan Niaki, S. T ; Sharif University of Technology
    Abstract
    Blood transfusion services are vital components of healthcare systems all over the world. In this paper, a generalized network optimization model is developed for a complex blood supply chain in accordance with Iranian blood transfusion organization (IBTO) structure. This structure consist of four types facilities. Blood collection centers, blood collection and processing centers, mobile teams and blood transfusion center have various duties in IBTO structure. The major contribution is to develop a novel hybrid approach based on stochastic programming, ε-constraint and robust optimization (HSERO) to simultaneously model two types of uncertainties by including stochastic scenarios for total... 

    Conceptual modeling of cardiovascular sounds

    , Article 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005, Shanghai, 1 September 2005 through 4 September 2005 ; Volume 7 VOLS , 2005 , Pages 2308-2311 ; 05891019 (ISSN); 0780387406 (ISBN); 9780780387409 (ISBN) Pouladian, M ; Tehrani Fard, A. A ; Sharif University of Technology
    Institute of Electrical and Electronics Engineers Inc  2005
    Abstract
    In this paper, it is shown that the main source of mechanical energy of cardiovascular (CV) system i.e., rhythmic heart contraction is transformed to the oscillations of the CV walls and blood flow, and finally CV acoustical waves. These waves propagate through both blood flow (hemodynamical pathways) and tissues (viscoelastical pathways) toward the skin. Nonetheless, the CV walls could be assumed as the source of acoustical waves, since they act as the interface between blood flows and other tissues including skin. After obtaining the approximate accelerations of CV walls from pressure-flow (PF) models, we also needed to model the viscoelastical pathways until the skin. Some improvements on... 

    Thermodynamic properties of aqueous glucose-urea-salt systems

    , Article Journal of Solution Chemistry ; Volume 43, Issue 6 , June , 2014 , Pages 1110-1131 ; ISSN: 00959782 Sadeghi, M ; Held, C ; Ghotbi, C ; Abdekhodaie, M. J ; Sadowski, G ; Sharif University of Technology
    Abstract
    In this work, the thermodynamic behavior of aqueous solutions containing the solutes NaCl, glucose, and/or urea is investigated. These substances are vital components for living bodies and further they are main components of blood serum. Osmotic coefficients were determined by cryoscopic measurements in single-solute and multi-solute aqueous solutions containing salts (NaCl, KCl, CaCl2), glucose, and/or urea. The results show that NaCl determines the osmotic coefficients in the urea/glucose/NaCl/water system. Investigation of the effect of different salts on osmotic coefficients revealed ion-specific effects. At physiologically important solute concentrations in typical blood serum... 

    Analytical and numerical evaluation of steady flow of blood through artery

    , Article Biomedical Research (India) ; Volume 24, Issue 1 , 2013 , Pages 88-98 ; 0970938X (ISSN) Sedaghatizadeh, N ; Barari, A ; Soleimani, S ; Mofidi, M ; Sharif University of Technology
    2013
    Abstract
    Steady blood flow through a circular artery with rigid walls is studied by COSSERAT Continuum Mechanical Approach. To obtain the additional viscosities coefficients, feed forward multi-layer perceptron (MLP) type of artificial neural networks (ANN) and the results obtained in previous empirical works is used. The governing filed equations are derived and solution to the Hagen-Poiseuilli flow of a COSSERAT fluid in the artery is obtained analytically by Homotopy Perturbation Method (HPM) and numerically using finite difference method. Comparison of analytical results with numerical ones showed excellent agreement. In addition microrotation and the velocity profile along the radius are... 

    Introducing an adaptive robust controller for artificial heart

    , Article Proceedings of the IEEE RAS and EMBS International Conference on Biomedical Robotics and Biomechatronics, 24 June 2012 through 27 June 2012 ; June , 2012 , Pages 413-418 ; 21551774 (ISSN) ; 9781457711992 (ISBN) Ravanshadi, S ; Jahed, M ; Sharif University of Technology
    2012
    Abstract
    Prolonged and uncontrolled high shear stresses and turbulence can cause hemolysis, while alternating and low-level stresses may contribute to platelet activation and thrombus formation. Such deficiencies are reported for Total Artificial Heart (TAH) systems which are generally not fully capable of dynamic adaptation to sudden pressure and volume changes. This study introduces an adaptive robust controller for a linear motor based TAH (LMTAH) which overcomes such shortcomings. Proposed controller performance is compared with simulated natural heart in normal and stressed physiological conditions. Application of adaptive robust control results in flows with less stress variation and... 

    Cuff-less high-accuracy calibration-free blood pressure estimation using pulse transit time

    , Article Proceedings - IEEE International Symposium on Circuits and Systems, 24 May 2015 through 27 May 2015 ; Volume 2015-July , 2015 , Pages 1006-1009 ; 02714310 (ISSN) ; 9781479983919 (ISBN) Kachuee, M ; Kiani, M.M ; Mohammadzade, H ; Shabany, M ; Sharif University of Technology
    Institute of Electrical and Electronics Engineers Inc  2015
    Abstract
    Recently a few methods have been proposed in the literature for non-invasive cuff-less estimation of systolic and diastolic blood pressures. One of the most prominent methods is to use the Pulse Transit Time (PTT). Although it is proven that PTT has a strong correlation with the systolic and diastolic blood pressures, this relation is highly dependent to each individuals physiological properties. Therefore, it requires per person calibration for accurate and reliable blood pressure estimation from PTT, which is a big drawback. To alleviate this issue, in this paper, a novel method is proposed for accurate and reliable estimation of blood pressure that is calibration-free. This goal is... 

    Improving blood bank inventory management using double cross-match and hybrid issuance policy

    , Article 7th IEEE International Conference on Industrial Engineering and Applications, ICIEA 2020, 16 April 2020 through 21 April 2020 ; 2020 , Pages 819-826 Bozorgi, A ; Najafi, M ; Sharif University of Technology
    Institute of Electrical and Electronics Engineers Inc  2020
    Abstract
    Blood availability in hospitals is of high humanitarian importance, thus blood shortage is not desired at all. High wastage rate of blood in hospitals is an important issue, which becomes more important as the standards of health care services becomes higher. In order to address blood shortage and wastage issues in a hospital, this paper develops a new inventory management model as a decision making tool to help making tactical and operational level decisions for a Hospital Blood Bank (HBB) inventory management. These decisions include issuance and ordering policy and the aim of the model is to reduce blood wastage and shortage. For this purpose, a multi period, multi-product inventory... 

    Quick, single-frequency dielectric characterization of blood samples of pediatric cancer patients by a cylindrical capacitor: Pilot study

    , Article Electronics (Switzerland) ; Volume 9, Issue 1 , 2020 Ghanbarzadeh Daghian, A ; Ahmadian, M. T ; Ghanbarzadeh Dagheyan, A ; Sharif University of Technology
    MDPI AG  2020
    Abstract
    In this paper, as an application in biometrics, the electrical capacitance of normal and cancerous blood samples is experimentally determined in order to test the null hypothesis that the electrical capacitance of the two samples differs. The samples taken from healthy donors and patients diagnosed with different types of hematologic cancer are examined by a cylindrical capacitor with blood as its dielectric. The capacitance of these samples is measured at room temperature and a single frequency of 120 Hz, well below the frequency where β-dispersion starts, using a simple LCR meter device. The measurements indicate that the capacitance of the blood increases under applied electric field for... 

    A novel panel of blood-based microRNAs capable of discrimination between benign breast disease and breast cancer at early stages

    , Article RNA Biology ; 2021 ; 15476286 (ISSN) Sadeghi, H ; Kamal, A ; Ahmadi, M ; Najafi, H ; Sharifi Zarchi, A ; Haddad, P ; Shayestehpour, B ; Kamkar, L ; Salamati, M ; Geranpayeh, L ; Lashkari, M ; Totonchi, M ; Sharif University of Technology
    Taylor and Francis Ltd  2021
    Abstract
    Breast cancer (BC) as a leading cause of cancer death among women, exhibits a wide range of genetic heterogeneity in affected individuals. Satisfactory management of BC depends on early diagnosis and proper monitoring of patients’ response to therapy. In this study, we aimed to assess the relation between the expression patterns of blood-based microRNAs (miRNAs) with demographic characteristics of the patients with BC in an attempt to find novel diagnostic markers for BC with acceptable precision in clinical applications. To this end, we performed comprehensive statistical analysis of the data of the Cancer Genome Atlas (TCGA) database and the blood miRNome dataset (GSE31309). As a result,... 

    Cuffless blood pressure estimation algorithms for continuous health-care monitoring

    , Article IEEE Transactions on Biomedical Engineering ; Volume 64, Issue 4 , 2017 , Pages 859-869 ; 00189294 (ISSN) Kachuee, M ; Kiani, M. M ; Mohammadzade, H ; Shabany, M ; Sharif University of Technology
    IEEE Computer Society  2017
    Abstract
    Goal: Continuous blood pressure (BP) monitoring can provide invaluable information about individuals' health conditions. However, BP is conventionally measured using inconvenient cuff-based instruments, which prevents continuous BP monitoring. This paper presents an efficient algorithm, based on the pulse arrival time (PAT), for the continuous and cuffless estimation of the systolic BP, diastolic blood pressure (DBP), and mean arterial pressure (MAP) values. Methods: The proposed framework estimates the BP values through processing vital signals and extracting two types of features, which are based on either physiological parameters or whole-based representation of vital signals. Finally,... 

    An Inventory Model for Hospital Blood bank with the Objective of Minimizing Wastage and Shortage

    , M.Sc. Thesis Sharif University of Technology Eskandari, Hanieh (Author) ; Modarres Yazdi, Mohammad (Supervisor)
    Abstract
    In this research, among the levels of the blood supply chain, hospital is chosen for study because of its importance. A model of inventory management of hospital blood bank is presented. In this case, we consider some assumptions which are more realistic. These assumptions include two types of emergency and ordinary demands, young blood demand, and finally, a cross-match process. In the existing articles, although blood groups considered in mathematical models, the priority of allocation of blood groups is not considered in these articles. In this study, three mathematical models are developed with deterministic parameters. In the first model, the assumption of ordinary and emergency demand,... 

    Simulation of red blood cell motion in microvessels using modified moving particle semi-implicit method

    , Article Scientia Iranica ; Volume 19, Issue 1 , 2012 , Pages 113-118 ; 10263098 (ISSN) Ahmadian, M. T ; Firoozbakhsh, K ; Hasanian, M ; Sharif University of Technology
    Abstract
    Red Blood Cells (RBCs) are the main cells in human blood, with a main role in the mechanical properties of blood as a fluid. Several methods have been improved to simulate the mechanical behavior of RBC in micro-capillaries. Since, in microscopic scales, using discrete models is more preferred than continuum methods, the Moving Particle Semi-Implicit method (MPS), which is a recent innovative particle based method, can simulate micro-fluidic flows based on NavierStokes equations. Although, by recent developments, the MPS method has turned into a considerable tool for modeling blood flow in micro meter dimensions, some problems, such as a commitment to use small time step sizes, still... 

    Design and Prototype Blood Warmer

    , M.Sc. Thesis Sharif University of Technology Shojaei Mehrizi, Nader (Author) ; Sayyadi, Hassan (Supervisor)
    Abstract
    Warming the injectable blood is a set of methods used to transfuse blood to the supplier (Accident patients, surgery, dialysis). These methods raise the temperature of the injected blood to body temperature. Blood transfusions are performed directly before World War II, so there is no need to heat the blood, Increased need for blood units caused blood banks. In these banks, to prevent the proliferation of pathogens, the temperature of blood units is reduced to 2-6 degrees Celsius. For indirect injection of these blood units, the injection temperature should be brought to the patient's body temperature before injection to prevent the recipient's body temperature from decreasing.In this... 

    A metabonomics investigation of multiple sclerosis by nuclear magnetic resonance

    , Article Magnetic Resonance in Chemistry ; Volume 51, Issue 2 , DEC , 2013 , Pages 102-109 ; 07491581 (ISSN) Mehrpour, M ; Kyani, A ; Tafazzoli, M ; Fathi, F ; Joghataie, M. T ; Sharif University of Technology
    2013
    Abstract
    Multiple sclerosis (MS) is a nervous system disease that affects the fatty myelin sheaths around the axons of the brain and spinal cord, leading to demyelination and a broad range of signs and symptoms. MS can be difficult to diagnose because its signs and symptoms may be similar to other medical problems. To find out which metabolites in serum are effective for the diagnosis of MS, we utilized metabolic profiling using proton nuclear magnetic resonance spectroscopy (1H-NMR). Random forest (RF) was used to classify the MS patients and healthy subjects. Atomic absorption spectroscopy was used to measure the serum levels of selenium. The results showed that the levels of selenium were lower in... 

    Mathematical modeling of heart rate and blood pressure variations due to changes in breathing pattern

    , Article 2013 20th Iranian Conference on Biomedical Engineering, ICBME 2013, Tehran, 18 December 2013 through 20 December 2013 ; 2013 , Pages 54-58 Goldoozian, L. S ; Zahedi, E ; Sharif University of Technology
    IEEE Computer Society  2013
    Abstract
    Analysis of the heart rate (HR) variation due to respiration, known as respiratory sinus arrhythmia (RSA), is a method to assess the autonomic nervous system (ANS) function. In this paper a physiologically-based mathematical model consisting of the cardiorespiratory system and ANS control has been used in order to study the cardiovascular response (mean arterial blood pressure and HR) to breathing with different respiration rates and tidal volumes. Simulation results show that RSA has its maximal amplitude at the respiration frequency of 0.12 Hz and that RSA amplitude varies linearly by tidal volume. These results are in agreement with real data from the literature. In addition, the... 

    Robust control of LVAD based on the sub-regional modeling of the heart

    , Article Scientia Iranica ; Volume 23, Issue 6 , 2016 , Pages 2934-2943 ; 10263098 (ISSN) Ravanshadi, S ; Jahed, M ; Sharif University of Technology
    Sharif University of Technology  2016
    Abstract
    Left Ventricular Assist Devices (LVAD) have received renewed interest as a bridge-to-transplantation as well as a bridge-to-recovery device. Ironically, reports of malfunction and complications have hindered the growth of this device. In particular, the main concern is LVAD's susceptibility to excessive backlash and suction as a result of ows that are either too low or high, respectively. This study utilizes a well-established physiological model of the cardiovascular system as a reliable platform to study a proposed adaptive robust controller for a rotary motor based LVAD which overcomes such shortcomings. Proposed controller performance is evaluated by comparing simulated natural heart...