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    Dynamic analysis of magnetic nanoparticles crossing cell membrane

    , Article Journal of Magnetism and Magnetic Materials ; Volume 429 , 2017 , Pages 372-378 ; 03048853 (ISSN) Pedram, M. Z ; Shamloo, A ; Ghafar Zadeh, E ; Alasty, A ; Sharif University of Technology
    Elsevier B.V  2017
    Abstract
    Nowadays, nanoparticles (NPs) are used in a variety of biomedical applications including brain disease diagnostics and subsequent treatments. Among the various types of NPs, magnetic nanoparticles (MNPs) have been implemented by many research groups for an array of life science applications. In this paper, we studied MNPs controlled delivery into the endothelial cells using a magnetic field. Dynamics equations of MNPs were defined in the continuous domain using control theory methods and were applied to crossing the cell membrane. This study, dedicated to clinical and biomedical research applications, offers a guideline for the generation of a magnetic field required for the delivery of... 

    Dynamic analysis of magnetic nanoparticles crossing cell membrane

    , Article Journal of Magnetism and Magnetic Materials ; Volume 422 , 2017 , Pages 464- ; 03048853 (ISSN) Pedram, M. Z ; Shamloo, A ; Ghafar Zadeh, E ; Alasty, E. Y. C. A ; Sharif University of Technology
    Elsevier B.V  2017
    Abstract
    Nowadays, nanoparticles (NPs) are used in a variety of biomedical applications including brain disease diagnostics and subsequent treatments. Among the various types of NPs, magnetic nanoparticles (MNPs) have been implemented by many research groups for an array of life science applications. In this paper, we studied MNPs controlled delivery into the endothelial cells using a magnetic field. Dynamics equations of MNPs were defined in the continuous domain using control theory methods and were applied to crossing the cell membrane. This study, dedicated to clinical and biomedical research applications, offers a guideline for the generation of a magnetic field required for the delivery of... 

    Steered molecular dynamic simulation approaches for computing the blood brain barrier (BBB) diffusion coefficient

    , Article IFMBE Proceedings ; Volume 51 , 2015 , Pages 1699-1703 ; 16800737 (ISSN) ; 9783319193878 (ISBN) Pedram, M. Z ; Shamloo, A ; Alasti, A ; Zadeh, E. G ; Jaffray D. A ; Sharif University of Technology
    Springer Verlag  2015
    Abstract
    In the recent years a great attention of research deals with different physical and biological aspects of the BBB structure, a robust shield that separates the blood and brain, a recent research held by the authors of this paper has focused on figuring out computing the diffusion coefficient of endothelial cell membrane. In this study, the major efforts have been concentrated on calculating a standardized measure for the amount of permeability and diffusion of this barrier. As a result, this work is dedicated to molecular dynamics (MD) simulation of calculating the interaction force between nano-particle and BBB membrane. data is recorded by using steered molecular dynamics simulation and... 

    Optimal magnetic field for crossing super-para-magnetic nanoparticles through the Brain Blood Barrier: A computational approach

    , Article Biosensors ; Volume 6, Issue 2 , 2016 ; 20796374 (ISSN) Pedram, M. Z ; Shamloo, A ; Alasty, A ; Ghafar Zadeh, E ; Sharif University of Technology
    MDPI AG  2016
    Abstract
    This paper scrutinizes the magnetic field effect to deliver the superparamagnetic nanoparticles (SPMNs) through the Blood Brain Barrier (BBB). Herein we study the interaction between the nanoparticle (NP) and BBB membrane using Molecular Dynamic (MD) techniques. The MD model is used to enhance our understanding of the dynamic behavior of SPMNs crossing the endothelial cells in the presence of a gradient magnetic field. Actuation of NPs under weak magnetic field offers the great advantage of a non-invasive drug delivery without the risk of causing injury to the brain. Furthermore, a weak magnetic portable stimulator can be developed using low complexity prototyping techniques. Based on MD... 

    Dynamics of Magnetic Nanoparticles in Biologically Inspired Flows under Effect of Electric and Magnetic Fields with Application in Epilepsy Detection

    , Ph.D. Dissertation Sharif University of Technology Zamani Pedram, Maysam (Author) ; Alasty, Aria (Supervisor) ; Ghaffarzadeh, Ebrahim (Supervisor) ; Shamloo, Amir (Co-Advisor)
    Abstract
    This thesis presents my Ph.D. research study focusing on the dynamic analysis of magnetic nanoparticles (MNPs) for epilepsy and blood-brain barrier (BBB) applications. In this analysis, we took into account various parameters including the magnetic field, fluid behavior, geometry and material of MNPs. Based on this computational study, the generated magnetic field in epileptic foci results in the aggregation of nanoparticles. This may offer the advantage of using MNPs as a Magnetic Resonance Imaging (MRI) contrast agent. Furthermore, in this study, we also demonstrated and discussed the advantage of MNPs for crossing BBB using the external magnetic field. The outcome of this research project... 

    Controlling differentiation of stem cells for developing personalized organ-on-chip platforms

    , Article Advanced Healthcare Materials ; Volume 7, Issue 2 , 2018 ; 21922640 (ISSN) Geraili, A ; Jafari, P ; Sheikh Hassani, M ; Heidary Araghi, B ; Mohammadi, M. H ; Ghafari, A. M ; Hassanpour Tamrin, S ; Pezeshgi Modarres, H ; Rezaei Kolahchi, A ; Ahadian, S ; Sanati Nezhad, A ; Sharif University of Technology
    Wiley-VCH Verlag  2018
    Abstract
    Organ-on-chip (OOC) platforms have attracted attentions of pharmaceutical companies as powerful tools for screening of existing drugs and development of new drug candidates. OOCs have primarily used human cell lines or primary cells to develop biomimetic tissue models. However, the ability of human stem cells in unlimited self-renewal and differentiation into multiple lineages has made them attractive for OOCs. The microfluidic technology has enabled precise control of stem cell differentiation using soluble factors, biophysical cues, and electromagnetic signals. This study discusses different tissue- and organ-on-chip platforms (i.e., skin, brain, blood–brain barrier, bone marrow, heart,... 

    Superparamagnetic iron oxide nanoparticles (SPIONs): Development, surface modification and applications in chemotherapy

    , Article Advanced Drug Delivery Reviews ; Volume 63, Issue 1-2 , January–February , 2011 , Pages 24-46 ; 0169409X (ISSN) Mahmoudi, M ; Sant, S ; Wang, B ; Laurent, S ; Sen, T ; Sharif University of Technology
    2011
    Abstract
    At present, nanoparticles are used for various biomedical applications where they facilitate laboratory diagnostics and therapeutics. More specifically for drug delivery purposes, the use of nanoparticles is attracting increasing attention due to their unique capabilities and their negligible side effects not only in cancer therapy but also in the treatment of other ailments. Among all types of nanoparticles, biocompatible superparamagnetic iron oxide nanoparticles (SPIONs) with proper surface architecture and conjugated targeting ligands/proteins have attracted a great deal of attention for drug delivery applications. This review covers recent advances in the development of SPIONs together... 

    Recent advances in the design and applications of amyloid-β peptide aggregation inhibitors for Alzheimer’s disease therapy

    , Article Biophysical Reviews ; Volume 11, Issue 6 , 2019 , Pages 901-925 ; 18672450 (ISSN) Jokar, S ; Khazaei, S ; Behnammanesh, H ; Shamloo, A ; Erfani, M ; Beiki, D ; Bavi, O ; Sharif University of Technology
    Springer  2019
    Abstract
    Alzheimer’s disease (AD) is an irreversible neurological disorder that progresses gradually and can cause severe cognitive and behavioral impairments. This disease is currently considered a social and economic incurable issue due to its complicated and multifactorial characteristics. Despite decades of extensive research, we still lack definitive AD diagnostic and effective therapeutic tools. Consequently, one of the most challenging subjects in modern medicine is the need for the development of new strategies for the treatment of AD. A large body of evidence indicates that amyloid-β (Aβ) peptide fibrillation plays a key role in the onset and progression of AD. Recent studies have reported...