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blood-compatibility
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Pyromellitic dianhydride crosslinked cyclodextrin nanosponges for curcumin controlled release; formulation, physicochemical characterization and cytotoxicity investigations
, Article Journal of Microencapsulation ; Volume 36, Issue 8 , 2019 , Pages 715-727 ; 02652048 (ISSN) ; Zarrabi, A ; Caldera, F ; Trotta, F ; Ghias, N ; Sharif University of Technology
Taylor and Francis Ltd
2019
Abstract
Aim: In this study, a nanosponge structure was synthesised with capability of encapsulating curcumin as a model polyphenolic compound and one of the herbal remedies that have widely been considered due to its ability to treat cancer. Methods: FTIR, DSC and XRD techniques were performed to confirm the formation of the inclusion complex of the nanosponge-drug. Results: DSC and XRD patterns showed an increasing stability and a decreasing crystallinity of curcumin after formation of inclusion complex. Encapsulation efficiency was 98% (w/w) and a significant increase was observed in loading capacity (184% w/w). The results of cytotoxicity assessments demonstrated no cell toxicity on the healthy...
Free radical graft polymerization of 2-hydroxyethyl methacrylate and acrylic acid on the polysulfone membrane surface through circulation of reaction media to improve its performance and hemocompatibility properties
, Article Journal of Membrane Science ; Volume 564 , 2018 , Pages 762-772 ; 03767388 (ISSN) ; Mousavi, S. A ; Abdekhodaie, M. J ; Sadeghi, M ; Sharif University of Technology
Elsevier B.V
2018
Abstract
In this study, a new facile and cost effective method is used to modify polysulfone membrane surface in order to improve the hydrophilicity, antifouling, and blood compatibility. This modification was performed by adding two functional monomers on the dialysis membrane. Polysulfone (PSF) membranes containing polyvinylpyrrolidone were prepared via phase inversion technique. In the next step, free radical polymerization combined with surface polymerization was used to introduce acrylic acid (AA) and 2-hydroxyethyl methacrylate (HEMA) onto the polysulfone membrane surface via circulation of initiator and monomer solutions across the membrane surface, respectively. Various monomer concentrations...