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Separation of Plasma from Blood Using a Dielectrophoresis-Assisted Microfluidic Device
, M.Sc. Thesis Sharif University of Technology ; Mohammadi, Ali Asghar (Supervisor) ; Soltanieh, Mohammad (Supervisor)
Abstract
% of human blood makes up of plasma, that this plasma is a rich source of proteins that can be used as biomarkers for a variety of clinical diseases and laboratory research, therefore, it is necessary that the plasma be separate by a high purity percentage. Using a centrifuge It is a common method used to separate plasma from blood, but because it requires large equipment and a large volume of blood, as well as stress caused by centrifugal force, increases the probability of damage to the biomarkers, so it has been tried today that Use methods that are easy to transport and require a small amount of blood. The idea of using the microfluidic device has been put forward for the purpose of...
High throughput blood plasma separation using a passive PMMA microfluidic device
, Article Microsystem Technologies ; 2015 ; 09467076 (ISSN) ; Shamloo, A ; Mohammadaliha, N ; Hajghassem, H ; Mehrabadi, J. F ; Bazzaz, M ; Sharif University of Technology
Springer Verlag
2015
Abstract
Since plasma is rich in many biomarkers used in clinical diagnostic experiments, microscale blood plasma separation is a primitive step in most of microfluidic analytical chips. In this paper, a passive microfluidic device for on-chip blood plasma separation based on Zweifach–Fung effect and plasma skimming was designed and fabricated by hot embossing of microchannels on a PMMA substrate and thermal bonding process. Human blood was diluted in various times and injected into the device. The main novelty of the proposed microfluidic device is the design of diffuser-shaped daughter channels. Our results demonstrated that this design exerted a considerable positive influence on the separation...
High throughput blood plasma separation using a passive PMMA microfluidic device
, Article Microsystem Technologies ; Volume 22, Issue 10 , 2016 , Pages 2447-2454 ; 09467076 (ISSN) ; Shamloo, A ; Mohammadaliha, N ; Hajghassem, H ; Fallah Mehrabadi, J ; Bazzaz, M ; Sharif University of Technology
Springer Verlag
2016
Abstract
Since plasma is rich in many biomarkers used in clinical diagnostic experiments, microscale blood plasma separation is a primitive step in most of microfluidic analytical chips. In this paper, a passive microfluidic device for on-chip blood plasma separation based on Zweifach–Fung effect and plasma skimming was designed and fabricated by hot embossing of microchannels on a PMMA substrate and thermal bonding process. Human blood was diluted in various times and injected into the device. The main novelty of the proposed microfluidic device is the design of diffuser-shaped daughter channels. Our results demonstrated that this design exerted a considerable positive influence on the separation...
Numerical optimization and inverse study of a microfluidic device for blood plasma separation
, Article European Journal of Mechanics, B/Fluids ; Volume 57 , 2016 , Pages 31-39 ; 09977546 (ISSN) ; Vatankhah, P ; Bijarchi, M. A ; Sharif University of Technology
Elsevier Ltd
2016
Abstract
In this paper, a passive microfluidic device for continuous real time blood plasma separation has been studied and optimized. A numerical model is used to solve both the fluid flow and the particles confined within it. Red blood cells are considered as particles with diameter of 7μm. A parametric study is performed in order to characterize the effect of different parameters on separation and purity efficiency. In this study, four different variables were introduced to design the microfluidic device for blood plasma separation including: the angle between the daughter channels and the main channel, the widths, the diffuse angle and the number of daughter channels. Results show that the...