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    Raising quality and safety of platelet transfusion services in a patient-based integrated supply chain under uncertainty

    , Article Computers and Chemical Engineering ; Volume 106 , 2017 , Pages 355-372 ; 00981354 (ISSN) Ensafian, H ; Yaghoubi, S ; Modarres Yazdi, M ; Sharif University of Technology
    Abstract
    This paper develops a stochastic multi-period mixed-integer model for collection, production, storage, and distribution of platelet in Blood Transfusion Organizations ranging from blood collection centers to clinical points. In this model, the age of platelet and ABO-Rh priority matching rules are incorporated based on the type of patient to raise the quality and safety of platelet transfusion services. At first, a discrete Markov Chain Process is applied to predict the number of donors. Afterwards, the uncertain demand is captured using a two-stage stochastic programming. A challenging aspect of applying stochastic programming in a dynamic setting is to construct an appropriate set of... 

    Developing hyaluronic acid microgels for sustained delivery of platelet lysate for tissue engineering applications

    , Article International Journal of Biological Macromolecules ; Volume 144 , 2020 , Pages 837-846 Jooybar, E ; Abdekhodaie, M. J ; Karperien, M ; Mousavi, A ; Alvi, M ; Dijkstra, P. J ; Sharif University of Technology
    Elsevier B.V  2020
    Abstract
    Platelet lysate (PL), a blood product that contains high concentrations of growth factors (GFs), can be considered as a cost-effective source of multiple GFs. In this study, hyaluronic acid (HA) based microgels were developed for delivery of PL proteins. Spherical microgel were prepared using a water in oil emulsion method. First, hyaluronic acid was grafted with tyramine groups, after which prepared microdroplets were crosslinked via an enzymatic reaction in the presence of hydrogen peroxide and horseradish peroxidase. Because of electrostatic interactions, these microgels are promising carriers for positively charged proteins entrapment like most of the GFs. When microgels are incubated in... 

    Bilayered heparinized vascular graft fabricated by combining electrospinning and freeze drying methods

    , Article Materials Science and Engineering C ; Volume 94 , 2019 , Pages 1067-1076 ; 09284931 (ISSN) Khayat Norouzi, S ; Shamloo, A ; Sharif University of Technology
    Elsevier Ltd  2019
    Abstract
    Small diameter vascular grafts (<6 mm) are highly demanded for patients suffering from severe occluded arteries to be used as a bypass or substituted conduit. Fabricating a graft with appropriate structural, mechanical and cell growth properties which has simultaneously anti-thrombogenic trait is a challenge nowadays. Here, we proposed a bilayer heparinized vascular graft that can mimic the structural and mechanical characteristics close to those of the native coronary artery by combining electrospinning and freeze drying methods. In this study, the inner layer was made by co-electrospinning of synthetic polymer, poly-caprolactone (PCL) and the natural polymer, gelatin (Gel). Also, heparin... 

    Bilayered heparinized vascular graft fabricated by combining electrospinning and freeze drying methods

    , Article Materials Science and Engineering C ; Volume 94 , 2019 , Pages 1067-1076 ; 09284931 (ISSN) Khayat Norouzi, S ; Shamloo, A ; Sharif University of Technology
    Elsevier Ltd  2019
    Abstract
    Small diameter vascular grafts (<6 mm) are highly demanded for patients suffering from severe occluded arteries to be used as a bypass or substituted conduit. Fabricating a graft with appropriate structural, mechanical and cell growth properties which has simultaneously anti-thrombogenic trait is a challenge nowadays. Here, we proposed a bilayer heparinized vascular graft that can mimic the structural and mechanical characteristics close to those of the native coronary artery by combining electrospinning and freeze drying methods. In this study, the inner layer was made by co-electrospinning of synthetic polymer, poly-caprolactone (PCL) and the natural polymer, gelatin (Gel). Also, heparin...