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Total 65 records

    Autoregressive modeling of the photoplethysmogram AC signal amplitude changes after flow-mediated dilation in healthy and diabetic subjects

    , Article 2012 19th Iranian Conference of Biomedical Engineering, ICBME 2012 ; 2012 , Pages 170-173 ; 9781467331302 (ISBN) Amiri, M ; Zahedi, E ; Behnia, F ; Sharif University of Technology
    2012
    Abstract
    It is proved that the endothelial (artery inner lumen cells) function is associated with cardiovascular risk factors. Among all the common non-invasive methods employed in the research setting for assessing endothelial function, flow-mediated dilation is the most widely used one. This technique measures endothelial function by inducing reactive hyperemia using temporary arterial occlusion and measuring the resultant relative increase in blood vessel diameter via ultrasound. In this paper, the limitations associated with the ultrasound technique are overcome by using the photoplethysmogram (PPG) signal recorded during FMD. The correctness of this approach is investigated by modeling the AC... 

    Numerical study of the effect of vascular bed on heat transfer during high intensity focused ultrasound (HIFU) ablation of the liver tumor

    , Article Journal of Thermal Biology ; Volume 86 , 2019 ; 03064565 (ISSN) Mohammadpour, M ; Firoozabadi, B ; Sharif University of Technology
    Elsevier Ltd  2019
    Abstract
    In this study, the influence of vascular bed comprising terminal arterial branches on heat transfer in a liver tumor exposed to high intensity focused ultrasound (HIFU) is studied numerically. Also, the effect of vascular density on temperature distribution is investigated. A coupled set of acoustics, thermal, and fluid models is used to calculate the temperature distribution in the liver. The numerical model is established based on the Westervelt and bioheat equations along with the Navier-Stokes equations. Moreover, the acoustic streaming effect is included with Newtonian and non-Newtonian flow assumptions. It is found that in a vascular bed comprising terminal arterial branches, the... 

    Prevascularized micro-/nano-sized spheroid/bead aggregates for vascular tissue engineering

    , Article Nano-Micro Letters ; Volume 13, Issue 1 , 2021 ; 23116706 (ISSN) Rahimnejad, M ; Nasrollahi Boroujeni, N ; Jahangiri, S ; Rabiee, N ; Rabiee, M ; Makvandi, P ; Akhavan, O ; Varma, R. S ; Sharif University of Technology
    Springer Science and Business Media B.V  2021
    Abstract
    Efficient strategies to promote microvascularization in vascular tissue engineering, a central priority in regenerative medicine, are still scarce; nano- and micro-sized aggregates and spheres or beads harboring primitive microvascular beds are promising methods in vascular tissue engineering. Capillaries are the smallest type and in numerous blood vessels, which are distributed densely in cardiovascular system. To mimic this microvascular network, specific cell components and proangiogenic factors are required. Herein, advanced biofabrication methods in microvascular engineering, including extrusion-based and droplet-based bioprinting, Kenzan, and biogripper approaches, are deliberated with... 

    Mathematical study of probe arrangement and nanoparticle injection effects on heat transfer during cryosurgery

    , Article Computers in Biology and Medicine ; Volume 66 , Nov , 2015 , Pages 113-119 ; 00104825 (ISSN) Mirkhalili, S. M ; Ramazani S. A. A ; Nazemidashtarjandi, S ; Sharif University of Technology
    Elsevier Ltd  2015
    Abstract
    Blood vessels, especially large vessels have a greater thermal effect on freezing tissue during cryosurgery. Vascular networks act as heat sources in tissue, and cause failure in cryosurgery and reappearance of cancer. The aim of this study is to numerically simulate the effect of probe location and multiprobe on heat transfer distribution. Furthermore, the effect of nanoparticles injection is studied. It is shown that the small probes location near large blood vessels could help to reduce the necessary time for tissue freezing. Nanoparticles injection shows that the thermal effect of blood vessel in tissue is improved. Using Au, Ag and diamond nanoparticles have the most growth of ice ball... 

    Bi-directional ConvLSTM U-net with densley connected convolutions

    , Article 17th IEEE/CVF International Conference on Computer Vision Workshop, ICCVW 2019, 27 October 2019 through 28 October 2019 ; 2019 , Pages 406-415 ; 9781728150239 (ISBN) Azad, R ; Asadi Aghbolaghi, M ; Fathy, M ; Escalera, S ; Computer Vision Foundation; IEEE ; Sharif University of Technology
    Institute of Electrical and Electronics Engineers Inc  2019
    Abstract
    In recent years, deep learning-based networks have achieved state-of-the-art performance in medical image segmentation. Among the existing networks, U-Net has been successfully applied on medical image segmentation. In this paper, we propose an extension of U-Net, Bi-directional ConvLSTM U-Net with Densely connected convolutions (BCDU-Net), for medical image segmentation, in which we take full advantages of U-Net, bi-directional ConvLSTM (BConvLSTM) and the mechanism of dense convolutions. Instead of a simple concatenation in the skip connection of U-Net, we employ BConvLSTM to combine the feature maps extracted from the corresponding encoding path and the previous decoding up-convolutional... 

    Early cancer detection in blood vessels using mobile nanosensors

    , Article IEEE Transactions on Nanobioscience ; Volume 18, Issue 2 , 2019 , Pages 103-116 ; 15361241 (ISSN) Mosayebi, R ; Ahmadzadeh, A ; Wicke, W ; Jamali, V ; Schober, R ; Nasiri Kenari, M ; Sharif University of Technology
    Institute of Electrical and Electronics Engineers Inc  2019
    Abstract
    In this paper, we propose using mobile nanosensors (MNSs) for early stage anomaly detection. For concreteness, we focus on the detection of cancer cells located in a particular region of a blood vessel. These cancer cells produce and emit special molecules, so-called biomarkers, which are symptomatic for the presence of anomaly, into the cardiovascular system. Detection of cancer biomarkers with conventional blood tests is difficult in the early stages of a cancer due to the very low concentration of the biomarkers in the samples taken. However, close to the cancer cells, the concentration of the cancer biomarkers is high. Hence, detection is possible if a sensor with the ability to detect... 

    A multi-scale model for determining the effects of pathophysiology and metabolic disorders on tumor growth

    , Article Scientific Reports ; Volume 10, Issue 1 , 20 February , 2020 Nikmaneshi, M. R ; Firoozabadi, B ; Mozafari, A ; Munn, L. L ; Sharif University of Technology
    Nature Research  2020
    Abstract
    The search for efficient chemotherapy drugs and other anti-cancer treatments would benefit from a deeper understanding of the tumor microenvironment (TME) and its role in tumor progression. Because in vivo experimental methods are unable to isolate or control individual factors of the TME and in vitro models often do not include all the contributing factors, some questions are best addressed with systems biology mathematical models. In this work, we present a new fully-coupled, agent-based, multi-scale mathematical model of tumor growth, angiogenesis and metabolism that includes important aspects of the TME spanning subcellular-, cellular- and tissue-level scales. The mathematical model is... 

    Control Algorithm of Multi-agent Systems in Special Paths With an Applied Consideration in Biomechanical Engineering to Perform Operations of Interior Treatments

    , M.Sc. Thesis Sharif University of Technology Soltani, Ali (Author) ; Sayyadi, Hassan (Supervisor)
    Abstract
    In this project Deployment of multi-agent systems was studied. Maximum coverage over a point or curve or area is desired in deployment of multi-agent systems. A facility location optimization function was derived from geometrical concepts such as voronoi, n- geometric median and fermat-weber problem by optimization of which the deployment of multi-agent systems is performed. First, it is assumed that dynamic of agents is first order and second order .Next, it is assumed that agents are in a fluid. In all situations a suitable control algorithm was derived to optimize the facility location function to perform deployment. Next, another facility location function was derived by optimization... 

    Heat Transfer Modeling of Ultrasounic Hyperthermia

    , M.Sc. Thesis Sharif University of Technology Heydari, Mohsen (Author) ; Jahed, Mehran (Supervisor)
    Abstract
    Ultrasound hyperthermia is a commonly used noninvasive approach to destroy cancer tumors. High Intensity Focused Ultrasound (HIFU) is a technique based on hyperthermia. It creates short and local elevations of temperature at a focus site within the tissue of interest. The main goal of HIFU is to maintain the temperature between 50 and 100 °C for a few seconds (typically less than 10 s), in order to cause tissue necrosis. In order to predict the effects of hyperthermia, accurate and effective modeling is needed. This study considers a 3D simulation of the hyperthermia based on HIFU method in the liver tissue. Temperature distribution and lesion volume changes, with a temperature of above... 

    Modeling Kidney Vascular Structure Based on Parametric L-system

    , M.Sc. Thesis Sharif University of Technology Shadman, Shahriar (Author) ; Farhadi, Fatolah (Supervisor) ; Bozorgmehry Boozarjomehry, Ramin (Supervisor)
    Abstract
    Kidney is one of the most complicated organs in terms of functionality and physiology due to its complicated unique vascular structure. Previous investigations have focused on specific characteristics like length and diameter. Most of these methods are based on Image Processing techniques which prevent a comprehensive study in growth and changes of the vascular system. Lindenmyaer system (L-system) is a parallel rewriting system and a type of formal grammar and had been used to create graphs and natural patterns. By absorbing the physiological characteristics of the kidney and integrating them into parametric L-system, a highly dense and accurate vascular system could be generated with few... 

    Plaque structure affects mechanical stress distribution within blood vessels

    , Article Proceedings of the IASTED International Conference on Biomedical Engineering, BioMed 2014 ; 2014 , pp. 239-243 Mohseni, M ; Mehboudi, N ; Abdollahi, M ; Shamloo, A ; Naghdabadi, R ; Sharif University of Technology
    Abstract
    The main goal of this study is to investigate the effects of plaque structure on its stress distribution. Rupture of plaque causes cerebrovascular diseases which lead to high mortality rates all over the world. Computers are powerful tools to understand the mechanism of plaque rupture. In this study, 3D fluid structure interaction simulation is constructed in ABAQUS 6.13 to clarify the relation between stress distribution of plaque and its structure. A model of common carotid artery with distributed stenosis was chosen for the simulation. To investigate the effects of plaque structure on stress distribution, thickness of fibrous cap and lipid core size were varied in the stenosis.... 

    Thickness as an important parameter in designing vascular grafts

    , Article 2014 21st Iranian Conference on Biomedical Engineering, ICBME 2014 ; Nov , 2014 , p. 40-43 Mohseni, M ; Shamloo, A ; Samani, S. A ; Dodel, M ; Sharif University of Technology
    Abstract
    The main goal of this study is to investigate the role of vascular graft thickness in wall stress gradient in anastomosis region. Atherosclerosis is a common heart disease causes high mortality rates every year. The gold standard treatment of atherosclerosis is replacing with autologous vein extracted from patient's body. Since proper autologous vein is limited, researchers have made efforts to achieve compliance engineered blood vessels. Mechanical stress has great effect on both smooth muscle cells and endothelial cells and it is considered as a stimulus in plaque formation. In this study, we evaluate the role of thickness in wall stress of anastomosis region. For this purpose, two... 

    Thickness as an important parameter in designing vascular grafts

    , Article 2014 21st Iranian Conference on Biomedical Engineering, ICBME 2014, 26 November 2014 through 28 November 2014 ; November , 2014 , Pages 40-43 ; 9781479974177 (ISBN) Mohseni, M ; Shamloo, A ; Samani, S. A ; Dodel, M ; Sharif University of Technology
    Institute of Electrical and Electronics Engineers Inc  2014
    Abstract
    The main goal of this study is to investigate the role of vascular graft thickness in wall stress gradient in anastomosis region. Atherosclerosis is a common heart disease causes high mortality rates every year. The gold standard treatment of atherosclerosis is replacing with autologous vein extracted from patient's body. Since proper autologous vein is limited, researchers have made efforts to achieve compliance engineered blood vessels. Mechanical stress has great effect on both smooth muscle cells and endothelial cells and it is considered as a stimulus in plaque formation. In this study, we evaluate the role of thickness in wall stress of anastomosis region. For this purpose, two... 

    Integration of spatial fuzzy clustering with level set for segmentation of 2-D angiogram

    , Article IECBES 2014, Conference Proceedings - 2014 IEEE Conference on Biomedical Engineering and Sciences: "Miri, Where Engineering in Medicine and Biology and Humanity Meet", 8 December 2014 through 10 December 2014 ; December , 2015 , Pages 309-314 ; 9781479940844 (ISBN) Ghalehnovi, M ; Zahedi, E ; Fatemizadeh, E ; Sharif University of Technology
    Institute of Electrical and Electronics Engineers Inc  2015
    Abstract
    Coronary angiography is a vital instrument to detect the prevailing of vascular diseases, and accurate vascular segmentation acts a crucial role for proper quantitative analysis of the vascular tree morphological features. Level set methods are popular for segmenting the coronary arteries, but their performance is related to suitable start-up and optimum setting of regulating parameters, essentially done manually. This research presents a novel fuzzy level set procedure with the objective of segmentation of the coronary artery tree in 2-D X-ray angiography as automatically. It is clever to clearly develop from the early segmentation with spatial fuzzy grouping. The adjusting parameters of... 

    The importance of fluid-structure interaction simulation for determining the mechanical stimuli of endothelial cells and atheroprone regions in a coronary bifurcation

    , Article Scientia Iranica ; Volume 23, Issue 1 , 2016 , Pages 228-237 ; 10263098 (ISSN) Pakravan, H. A ; Saidi, M. S ; Firoozabadi, B ; Sharif University of Technology
    Sharif University of Technology  2016
    Abstract
    The function and morphology of Endothelial Cells (ECs) play a key role in atherosclerosis. The mechanical stimuli of ECs, such as Wall Shear Stress (WSS) and arterial wall strain, greatly inuence the function and morphology of these cells. The present article deals with computations of these stimuli for a 3D model of a healthy coronary artery bifurcation. The focus of the study is to propose an accurate method for computations of WSS and strains. Two approaches are considered: Coupled simultaneous simulation of arterial wall and blood flow, called fluid-Structure Interaction (FSI) simulation, and decoupled, which simulates each domain (fluid and solid domain) separately. The study... 

    A comparative study of collagen matrix density effect on endothelial sprout formation using experimental and computational approaches

    , Article Annals of Biomedical Engineering ; Volume 44, Issue 4 , 2016 , Pages 929-941 ; 00906964 (ISSN) Shamloo, A ; Mohammadaliha, N ; Heilshorn, S. C ; Bauer, A. L ; Sharif University of Technology
    Abstract
    A thorough understanding of determining factors in angiogenesis is a necessary step to control the development of new blood vessels. Extracellular matrix density is known to have a significant influence on cellular behaviors and consequently can regulate vessel formation. The utilization of experimental platforms in combination with numerical models can be a powerful method to explore the mechanisms of new capillary sprout formation. In this study, using an integrative method, the interplay between the matrix density and angiogenesis was investigated. Owing the fact that the extracellular matrix density is a global parameter that can affect other parameters such as pore size, stiffness,... 

    Simulation of low density lipoprotein (LDL) permeation into multilayer coronary arterial wall: interactive effects of wall shear stress and fluid-structure interaction in hypertension

    , Article Journal of Biomechanics ; 2017 ; 00219290 (ISSN) Roustaei, M ; Nikmaneshi, M. R ; Firoozabadi, B ; Sharif University of Technology
    Abstract
    Due to increased atherosclerosis-caused mortality, identification of its genesis and development is of great importance. Although, key factors of the origin of the disease is still unknown, it is widely believed that cholesterol particle penetration and accumulation in arterial wall is mainly responsible for further wall thickening and decreased rate of blood flow during a gradual progression. To date, various effective components are recognized whose simultaneous consideration would lead to a more accurate approximation of Low Density Lipoprotein (LDL) distribution within the wall. In this research, a multilayer Fluid-Structure Interaction (FSI) model is studied to simulate the penetration... 

    Beat pressure and comparing it with ascending aorta pressure in normal and abnormal conditions

    , Article 4th European Conference of the International Federation for Medical and Biological Engineering, ECIFMBE 2008, Antwerp, 23 November 2008 through 27 November 2008 ; Volume 22 , 2008 , Pages 276-285 ; 16800737 (ISSN); 9783540892076 (ISBN) Ghasmelizadeh, O ; Mirzaee, M. R ; Firoozabadi, B ; Sajadi, B ; Zolfonoon, A ; Sharif University of Technology
    2008
    Abstract
    Lumped method (Electrical analogy) is a quick and easy way to model human cardiovascular system. In this paper Lumped method is used for simulating a complete model. It describes a 36-vessel model and cardiac system of human body with details that could show hydrodynamic parameters of cardiovascular system. Also this paper includes modeling of pulmonary, atrium, left and right ventricles with their equivalent circuits. Exact modeling of right and left ventricles pressure with division of ascending aorta into 27 segments increases the accuracy of our simulation. In this paper we show that a calculated pressure for aorta from our complex circuit is near to measured pressure by using advanced... 

    Exact modeling of cardiovascular system using lumped method

    , Article 2008 International Conference on Bioinformatics and Computational Biology, BIOCOMP 2008, Las Vegas, NV, 14 July 2008 through 17 July 2008 ; 2008 , Pages 408-417 ; 1601320558 (ISBN); 9781601320551 (ISBN) Ghasemalizadeh, O ; Mirzaee, M. R ; Firoozabadi, B ; Hassani, K ; Sharif University of Technology
    2008
    Abstract
    Electrical analogy (Lumped method) is an easy way to model human cardiovascular system. In this paper Lumped method is used for simulating a complete model. It describes a 36-vessel model and cardiac system of human body with details that could show hydrodynamic parameters of cardiovascular system. Also this paper includes modeling of pulmonary, atrium, left and right ventricles with their equivalent circuits. Exact modeling of right and left ventricles pressure increases the accuracy of our simulation. In this paper we show that a calculated pressure for aorta from our complex circuit is near to measured pressure by using advanced medical instruments  

    Effects of Brownian motions and thermophoresis diffusions on the hematocrit and LDL concentration/diameter of pulsatile non-Newtonian blood in abdominal aortic aneurysm

    , Article Journal of Non-Newtonian Fluid Mechanics ; Volume 294 , 2021 ; 03770257 (ISSN) Abbasi, M ; Esfahani, A. N ; Golab, E ; Golestanian, O ; Ashouri, N ; Sajadi, S. M ; Ghaemi, F ; Baleanu, D ; Karimipour, A ; Sharif University of Technology
    Elsevier B.V  2021
    Abstract
    LDL concentration is believed to be responsible for plaque formation that leads to atherosclerotic cardiovascular disease. We conducted this study to investigate the effects of hematocrits and LDL diameters on LDL concentration on the wall of an abdominal aortic aneurysm (AAA). The blood flow was considered to be a pulsatile and non-Newtonian flow whose viscosity was a function of hematocrits and strain rate. Lumen, Brownian, and thermophoresis diffusions were analyzed in LDL concentration. The results demonstrated that adding thermophoresis diffusion increases LDL concentration. Moreover, among three types of LDLs, including small LDLs, intermediate LDLs, and large LDLs, small LDLs were the...