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    Evaluation of ascorbic acid-loaded calcium phosphate bone cements: Physical properties and in vitro release behavior

    , Article Ceramics International ; Vol. 40, issue. 3 , April , 2014 , pp. 3961-3968 ; ISSN: 02728842 Hemmati, K ; Hesaraki, S ; Nemati, A ; Sharif University of Technology
    In this study, different concentrations of ascorbic acid (50, 100 and 200 μg/mL) were added to the liquid phase of a calcium phosphate cement (CPC). The cements were immersed in simulated body fluid (SBF) for different intervals and physical, physicochemical and mechanical properties of them were evaluated. The release of added ascorbic acid from CPCs into the SBF solution was also studied. From the results, both setting time and injectability of CPC decreased by adding ascorbic acid, however the compressive strength was sharply increased before soaking in SBF solution. But, the compressive strength values of all cements (with or without ascorbic acid) soaked in SBF solution for more than 7... 

    Synthesis of Bone graft Substitute for Clinical Applications

    , M.Sc. Thesis Sharif University of Technology Khodabakhshi Tabar Ahangar, Zahra (Author) ; Abdekhodaie, Mohammad Jafar (Supervisor)
    The natural tissue of the bones consists of organic and inorganic parts. The bone mineral part contains calcium phosphate and its organic part is mainly of collagen fibers. The combination of these fibers and calcium phosphate makes the bone flexible and resistant to stresses. Many conditions, including osteoporosis and crashes, lead to fractures and cavities in bone. Bone cements are the most used materials used in orthopedic surgeries and spinal cord.The purpose of this study was to synthesis acrylic bone cement with properties determined by ASTM F 451 and Iso5833 for orthopedic applications, including joint replacement. Polymethyl methacrylate polymer was synthesized as the main component... 

    Controlled Release Delivery System for Antibiotic in Bone Cement

    , M.Sc. Thesis Sharif University of Technology Beyki Sarve ol’ya, Mohammad Saeed (Author) ; Abd Khodaei, Mohammad Jafar (Supervisor)
    The incidence of skeletal diseases such as osteoarthritis and its progression and the need to use knee replacement implants have significant effects on the quality of life. With the improvement of living conditions and the prolongation of the average life expectancy of the society and the aging of a large part of the society, the concern about the increase in the incidence of skeletal diseases and the need to use alternative implants increases. On the other hand, many conditions such as osteoporosis and accidents lead to fractures and cavities in the bones. Bone cements are one of the most widely used materials in orthopedic and spinal surgeries.The aim of this study was to construct a... 

    Design of Customized Cemented Stems for Hip Joint Arthroplasty Surgery in Patients with Severe Femoral Deformity

    , M.Sc. Thesis Sharif University of Technology Ebadi, Yashar (Author) ; Farahmand, Farzam (Supervisor)
    Hip replacement surgery is performed with the aim of relieving pain and restoring the normal function of the joint for patients who are in the final stages of arthritis. Standard prostheses offered by implant manufacturers come in a wide variety of models and sizes to meet the needs of patients. However, these commercial prostheses may not be suitable for patients with significant bony abnormalities, leading to implant instability and loosening. In such cases, a suitable solution is to use customized implants that are specifically designed to match the patient's unique anatomy. The purpose of this research was to design a customized cement stem for hip joint replacement surgery in patients... 

    Fabrication of Bioactive Bone Cement

    , M.Sc. Thesis Sharif University of Technology Mansoori Kermani, Amir Reza (Author) ; Bahrevari, Mohammad Reza (Supervisor) ; Mashayekhan, Shohreh (Supervisor) ; Abd Khodaei, Mohammad Jafar (Supervisor)
    PMMA bone cement lacks biodegradability and the ability to bond with surrounding bone tissue. Therefore, the development of a new generation of bioactive bone cements that are biodegradable and possess adequate mechanical properties as well as desirable setting time is receiving remarkable interest.In this study, we have developed novel mineral-based bioactive bone cements. Our mineral bioactive bone cements were composed of Calcium Sulfate Hemihydrate, Bioactive Glass, and Tricalcium Silicate. Firstly, a binary system composed of Calcium Sulfate Hemihydrate and Bioactive Glass was optimized based on mechanical and setting behavior. Secondly, Tricalcium Silicate was added to the powder phase... 

    Experimental investigation and finite element modelling of PMMA/carbon nanotube nanobiocomposites for bone cement applications

    , Article Soft Matter ; Volume 18, Issue 36 , 2022 , Pages 6800-6811 ; 1744683X (ISSN) Sadati, V ; Khakbiz, M ; Chagami, M ; Bagheri, R ; Chashmi, F. S ; Akbari, B ; Shakibania, S ; Lee, K. B ; Sharif University of Technology
    Royal Society of Chemistry  2022
    Multi-walled carbon nanotubes (MWCNTs) are one of the preferred candidates for reinforcing polymeric nanobiocomposites, such as acrylic bone type of cement. In this study, at first, bulk samples of the reinforced polymethylmethacrylate (PMMA) matrix were prepared with 0.1, 0.25, and 0.5 wt per wt% of MWCNTs by the casting method. Tensile and three-point bending tests were performed to determine the essential mechanical properties of bone cement, such as tensile and bending strengths. The tensile fracture surfaces were investigated by scanning electron microscopy (SEM). The commercial software (Abaqus) was used to conduct finite element analysis (FEA) by constructing a representative volume... 

    Thermoplastic starch/ethylene vinyl alcohol/forsterite nanocomposite as a candidate material for bone tissue engineering

    , Article Materials Science and Engineering C ; Volume 69 , 2016 , Pages 301-310 ; 09284931 (ISSN) Mahdieh, Z ; Bagheri, R ; Eslami, M ; Amiri, M ; Shokrgozar, M. A ; Mehrjoo, M ; Sharif University of Technology
    Elsevier Ltd 
    Recently, biodegradable polymers such as starch based blends have been well renowned in the biomedical field. Studies have considered them suitable for bone scaffolds, bone cements, tissue engineering scaffolds, drug delivery systems and hydrogels. The aim of this study was to synthesize nanocomposite biomaterial consisting a blend of thermoplastic starch and ethylene vinyl alcohol as the polymer matrix, and nano-structured forsterite as the ceramic reinforcing phase for bone tissue engineering applications. Furthermore, vitamin E was applied as a thermal stabilizer during melt compounding. Extrusion and injection molding were incorporated for melt blending and shaping of samples,...