Loading...
Search for:
bone-marrow-mesenchymal-stem-cells
0.006 seconds
Evaluation of differentiation quality of several differentiation inducers of bone marrow-derived mesenchymal stem cells to nerve cells by as-sessing expression of beta-tubulin 3 marker: A systematic review
, Article Current Stem Cell Research and Therapy ; Volume 16, Issue 8 , 2021 , Pages 994-1004 ; 1574888X (ISSN) ; Zahedi, F ; Hashemi, Z. S ; Khalili, S ; Sharif University of Technology
Bentham Science Publishers
2021
Abstract
Neurological diseases have different etiological causes. Contemporary, developing an ef-fective treatment for these diseases is an ongoing challenge. Cell therapy is recognized as one of the promising solutions for the treatment of these diseases. Amongst various types of stem cells, bone marrow-derived mesenchymal stem cells (BM-MSC) are known to be the most widely used stem cells. These cells are endowed with appealing properties such as the ability to differentiate into other cell types, including the muscle, liver, glial, and nerve cells. In this review study, we have systematically evaluated the ability of a variety of chemical compounds used in the last ten years to differentiate...
Enhanced chondrogenic differentiation of human bone marrow mesenchymal stem cells on PCL/PLGA electrospun with different alignments and compositions
, Article International Journal of Polymeric Materials and Polymeric Biomaterials ; Volume 67, Issue 1 , 2018 , Pages 50-60 ; 00914037 (ISSN) ; Mahmoudifard, M ; Soleimani, M ; Bakhshandeh, B ; Vasei, M ; Faghihi, S ; Sharif University of Technology
Taylor and Francis Inc
2018
Abstract
The simultaneous effect of electrospun scaffold alignment and polymer composition on chondrogenic differentiation of human bone marrow mesenchymal stem cells (hBMMSC) is investigated. Aligned and randomly oriented polycaprolactone/poly(lactic-co-glycolic acid) (PLGA) hybrid electrospun scaffolds with two different ratios are fabricated by electrospinning. It is found that aligned nanofibrous scaffolds support higher chondrogenic differentiation of hBMMSCs compared to random ones. The aligned scaffolds show a higher expression level of chondrogenic markers such as type II collagen and aggrecan. It is concluded that the aligned nanofibrous scaffold with higher PLGA ratio could significantly...
Study and Fabrication of a Microfluidic System to Investigate Stem Cell Differentiation
, M.Sc. Thesis Sharif University of Technology ; Vosoughi, Manouchehr (Supervisor) ; Alemzadeh, Iran (Supervisor)
Abstract
In recent years, many studies have conducted research about stem cells due to their prominent features such as proliferation and differentiation. By changing the specific parameters of the cellular micro-environment, it is possible to determine the stem cells fate and thereby use them in medical affairs. For this purpose, various devices and methods have been designeds such as microfluidic devices and scaffolds. The microfluidic devices has been especially focuced in the researchs due to their unique features, like the possibility of testing with small amounts of samples, the creation and control of low cost cellular micro-environment and low practical time. Two-dimensional scaffolds made up...
Investigation and Determination of Optimal Composition of Hydrogels and Nanoparticles for Proliferation of Mesenchymal Stem Cells in Alginate Beads
, M.Sc. Thesis Sharif University of Technology ; Yaghmaei, Soheila (Supervisor) ; Arpanaei, Ayyoob (Supervisor)
Abstract
The aim of this dissertation is to investigate and determine the optimal composition of hydrogels that can meet the needs of stem cells for the growth and proliferation of mesenchymal stem cells. In this research, firstly, unfunctionalized and functionalized mesoporous silica nanoparticles (with an average diameter of approximately 90 nm), were synthesized. Scanning electron microscopy and zeta potential measurement were utilized to study their morphology and surface charge. Then, graphene oxide nanosheets were synthesized. Field emission electron microscopy, zeta potential measurement and Fourier transform infrared spectrum analysis were used to examine their morphology, surface charge and...