Search for: bone-remodelling
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    Using a truss-inspired model with the uniform strength optimization theory to predict spongy bone geometry in proximal femur

    , Article American Journal of Applied Sciences ; Volume 6, Issue 3 , 2009 , Pages 449-455 ; 15469239 (ISSN) Pishdast, H ; Farahmand, F ; Rouhi, G. R ; Sharif University of Technology
    This paper presents a new naïve approach for simulating bone remodeling process. It is based on the uniform strength theory of optimization and employs a truss-like model for bone. The truss was subjected to external loads including 5 point loads simulating the hip joint contact forces and 3 muscular forces at the attachment sites of the muscles to the bone and the rest are reactions of ligaments. The strain in the links was calculated and the links with high strains were identified. The initial truss is modified by introducing new links wherever the strain exceeds a prescribed or critical value. The critical value was assumed to be equal to an average of the absolute value of strains in the... 

    Prediction of shape and internal structure of the proximal femur using a modified level set method for structural topology optimisation

    , Article Computer Methods in Biomechanics and Biomedical Engineering ; Volume 15, Issue 8 , 2012 , Pages 835-844 ; 10255842 (ISSN) Bahari, M. K ; Farahmand, F ; Rouhi, G ; Movahhedy, M. R ; Sharif University of Technology
    A computational framework was developed to simulate the bone remodelling process as a structural topology optimisation problem. The mathematical formulation of the Level Set technique was extended and then implemented into a coronal plane model of the proximal femur to simulate the remodelling of internal structure and external geometry of bone into the optimal state. Results indicated that the proposed approach could reasonably mimic the major geometrical and material features of the natural bone. Simulation of the internal bone remodelling on the typical gross shape of the proximal femur, resulted in a density distribution pattern with good consistency with that of the natural bone. When... 

    2-D Bone Structure Prediction of Proximal Femur and Dominant Joint Load Estimation using Level Set Method and Bone RemodelingTheories

    , M.Sc. Thesis Sharif University of Technology Keivan Bahari, Mahsa (Author) ; Farahmand, Farzam (Supervisor) ; Movahhedy, Mohammad Reza (Supervisor) ; Rouhi, Gholamreza (Co-Advisor)
    Bones adapt their form and structure to make an efficient use of their mass against the applied mechanical loads. So, it is not surprising to assume that the geometry and density distribution of a bone contains information about its loading history. The objective of this work was to develop a framework to simulate the bone remodeling procedure as a topology optimization process and then use this framework to develop a simple technique for estimating the dominant joint loads based on the bone’s density distribution.
    At first, the remodeling equation was derived from the structural optimization task of minimizing the strain energy in each time step, using the level set method. Employment... 

    Simulation of the Cellular Dynamics of Bone Remodeling and its Control Mechanisms

    , M.Sc. Thesis Sharif University of Technology Amiri, Behnam (Author) ; Zohoor, Hassan (Supervisor) ; Sohrabpour, Saeed (Co-Advisor)
    Bone is one of the most important biomechanical organs in animal bodies which comprises of a dynamic tissue that can change its internal structure through remodeling process. A comprehensive understanding of this process is of great significance in prevention and cure of many bone diseases. Due to the special conditions of hard bone tissue, empirical studies on the details of bone processes is very costly and time consuming. Thus, mathematical models and in silico simulations are key to unraveling how bone homeostasis imbalance can lead to pathological conditions. Therefore, in the recent years, there has been an increasing interest in modeling bone remodeling process in cellular level. In... 

    Nanomedicine applications in orthopedic medicine: State of the art

    , Article International Journal of Nanomedicine ; Volume 10 , 2015 , Pages 6039-6054 ; 11769114 (ISSN) Mazaheri, M ; Eslahi, N ; Ordikhani, F ; Tamjid, E ; Simchi, A ; Sharif University of Technology
    Dove Medical Press Ltd  2015
    The technological and clinical need for orthopedic replacement materials has led to significant advances in the field of nanomedicine, which embraces the breadth of nanotechnology from pharmacological agents and surface modification through to regulation and toxicology. A variety of nanostructures with unique chemical, physical, and biological properties have been engineered to improve the functionality and reliability of implantable medical devices. However, mimicking living bone tissue is still a challenge. The scope of this review is to highlight the most recent accomplishments and trends in designing nanomaterials and their applications in orthopedics with an outline on future directions...