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Mathematical modeling of CSF pulsatile hydrodynamics based on fluid-solid interaction
, Article IEEE Transactions on Biomedical Engineering ; Volume 57, Issue 6 , 2010 , Pages 1255-1263 ; 00189294 (ISSN) ; Bastani, D ; Najarian, S ; Ganji, F ; Farmanzad, F ; Seddighi, A. S ; Sharif University of Technology
2010
Abstract
Intracranial pressure (ICP) is derived from cerebral blood pressure and cerebrospinal fluid (CSF) circulatory dynamics and can be affected in the course of many diseases. Computer analysis of the ICP time pattern plays a crucial role in the diagnosis and treatment of those diseases. This study proposes the application of Linninger et al.s [IEEE Trans. Biomed. Eng. , vol. 52, no. 4, pp. 557565, Apr. 2005] fluidsolid interaction model of CSF hydrodynamic in ventricular system based on our clinical data from a group of patients with brain parenchyma tumor. The clinical experiments include the arterial blood pressure (ABP), venous blood pressure, and ICP in the subarachnoid space (SAS). These...
2D computational fluid dynamic modeling of human ventricle system based on fluid-solid interaction and pulsatile flow
, Article Basic and Clinical Neuroscience ; Volume 4, Issue 1 , 2013 , Pages 64-75 ; 2008126X (ISSN) ; Framanzad, F ; Zamanian, B ; Seddighi, A. S ; Moosavi, M. H ; Najarian, S ; Bastani, D ; Sharif University of Technology
2013
Abstract
Many diseases are related to cerebrospinal fluid (CSF) hydrodynamics. Therefore, understanding the hydrodynamics of CSF flow and intracranial pressure is helpful for obtaining deeper knowledge of pathological processes and providing better treatments. Furthermore, engineering a reliable computational method is promising approach for fabricating in vitro models which is essential for inventing generic medicines. A Fluid-Solid Interaction (FSI)model was constructed to simulate CSF flow. An important problem in modeling the CSF flow is the diastolic back flow. In this article, using both rigid and flexible conditions for ventricular system allowed us to evaluate the effect of surrounding brain...