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cadmium-telluride-quantum-dots
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Detection of L-Dopa Based on Fluorescent of levodopa Nanopolymers and CdTe Quantum Dots
, M.Sc. Thesis Sharif University of Technology ; Hormozi Nezhad, Mohammad Reza (Supervisor)
Abstract
Levodopa [L-3, 4-dihydroxyphenylalanine, or L-DOPA] is an important neurotransmitter used for the treatment of neural disorders such as Parkinson’s disease. Abnormal L-Dopa concentrations in biological fluids can be used for evaluation of diseases such as Parkinson’s diseases. In the first part of this thesis, a rapid and sensitive method for levodopa detection was reported which is based on in situ formation of polylevodopa nanoparticles. The assay is very simple and low cost and uses only NaOH and HCl as reagents. Under alkaline conditions, levodopa is spontaneously oxidized to its quinone derivative and shows the fluorescence properties. The fluorescence signal of the oxidation product of...
Cadmium telluride quantum dots induce apoptosis in human breast cancer cell lines
, Article Toxicology and Industrial Health ; Volume 34, Issue 5 , 2018 , Pages 339-352 ; 07482337 (ISSN) ; Zare, H ; Taghavinia, N ; Irajizad, A ; Aghaei, M ; Panjehpour, M ; Sharif University of Technology
SAGE Publications Ltd
2018
Abstract
Introduction: Semiconductor quantum dots (QDs), especially those containing cadmium, have undergone marked improvements and are now widely used nanomaterials in applicable biological fields. However, great concerns exist regarding their toxicity in biomedical applications. Because of the lack of sufficient data regarding the toxicity mechanism of QDs, this study aimed to evaluate the cytotoxicity of three types of QDs: CdTe QDs, high yield CdTe QDs, and CdTe/CdS core/shell QDs on two human breast cancer cell lines MDA-MB468 and MCF-7. Methods: The breast cancer cells were treated with different concentrations of QDs, and cell viability was evaluated via MTT assay. Hoechst staining was...
Identification of catecholamine neurotransmitters using fluorescence sensor array
, Article Analytica Chimica Acta ; Volume 917 , 2016 , Pages 85-92 ; 00032670 (ISSN) ; Hormozi Nezhad, M. R ; Mahmoudi, M ; Sharif University of Technology
Elsevier B.V
2016
Abstract
A nano-based sensor array has been developed for identification and discrimination of catecholamine neurotransmitters based on optical properties of their oxidation products under alkaline conditions. To produce distinct fluorescence response patterns for individual catecholamine, quenching of thioglycolic acid functionalized cadmium telluride (CdTe) quantum dots, by oxidation products, were employed along with the variation of fluorescence spectra of oxidation products. The spectral changes were analyzed with hierarchical cluster analysis (HCA) and principal component analysis (PCA) to identify catecholamine patterns. The proposed sensor could efficiently discriminate the individual...
Radial basis function-artificial neural network (RBF-ANN) for simultaneous fluorescent determination of cysteine enantiomers in mixtures
, Article Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy ; Volume 261 , 2021 ; 13861425 (ISSN) ; Reza Hormozi Nezhad, M ; Abdollahi, H ; Sharif University of Technology
Elsevier B.V
2021
Abstract
The determination of chiral compounds is critically important in chemical and pharmaceutical sciences. Cysteine amino acid is one of the important chiral compounds where each enantiomer (L and D) has different effects on fundamental physiological processes. The unique optical properties of nanoparticles make them a suitable probe for the determination of different analytes. In this work, the water-soluble thioglycolic acid (TGA)-capped cadmium-telluride (CdTe) quantum dots (QDs) were applied as optical nanoprobe for the simultaneous determination of cysteine enantiomers. The difference in the kinetics of the interactions between L- and D-cysteine with CdTe QDs is used for multivariate...