Search for: cancer-modeling
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    Modelling and Simulation of Melanoma Cancer, Based on Cellular Automata Approaches

    , M.Sc. Thesis Sharif University of Technology Rad, Jaber (Author) ; Habibi, Jafar (Supervisor)
    Nowadays, M&S is critical as a powerful tool for human to fight against cancer. Skin cancer is one of the most widespread cancers and melanoma would be the most dangerous kind of it. In cancerous micro-environment, cancer cells interact with vasculature, and compete with normal cells over nutrients. This plays a major role in tumor progression pattern and speed. In recent years, a few multiscale models have been developed considering these phenomena. Such a model provides a platform for future researches, especially in drug effects prediction. A reliable simulation must satisfy the constraints and facts in the real world as much as possible. M&S credibility assessment is a major concern to... 

    Modeling of Cancer Progression by Using Evolutionary Game Theory

    , M.Sc. Thesis Sharif University of Technology Malekian Boroujeni, Negin (Author) ; Habibi, Jafar (Supervisor)
    Mathematical modeling and computer simulation are powerful tools to help cancer research because they provide a good insight of cancer progression and an efficient framework to test biological hypothesis. Most of the previous studies ignored many intracellular communication between tumor cells. Gap junction is one of the interaction ways between tumor cells which plays a crucial role in cancer progression. In the first phase of this thesis, a model of intracellular communication through gap junction using evolutionary game theory scoring is proposed. In the second phase of this thesis, cancer is modeled by Markov decision process (MDP). Given that considering nutrient level constant is one... 

    Integrating evolutionary game theory into an agent-based model of ductal carcinoma in situ: Role of gap junctions in cancer progression

    , Article Computer Methods and Programs in Biomedicine ; Volume 136 , 2016 , Pages 107-117 ; 01692607 (ISSN) Malekian, N ; Habibi, J ; Zangooei, M. H ; Aghakhani, H ; Sharif University of Technology
    Elsevier Ireland Ltd 
    Background and objective There are many cells with various phenotypic behaviors in cancer interacting with each other. For example, an apoptotic cell may induce apoptosis in adjacent cells. A living cell can also protect cells from undergoing apoptosis and necrosis. These survival and death signals are propagated through interaction pathways between adjacent cells called gap junctions. The function of these signals depends on the cellular context of the cell receiving them. For instance, a receiver cell experiencing a low level of oxygen may interpret a received survival signal as an apoptosis signal. In this study, we examine the effect of these signals on tumor growth. Methods We make an... 

    Investigation of a two-step device implementing magnetophoresis and dielectrophoresis for separation of circulating tumor cells from blood cells

    , Article Engineering in Life Sciences ; Volume 20, Issue 7 , 2020 , Pages 296-304 Shamloo, A ; Yazdani, A ; Saghafifar, F ; Sharif University of Technology
    Wiley-VCH Verlag  2020
    Identifying tumor cells from a pool of other cells has always been an appealing topic for different purposes. The objective of this study is to discriminate circulating tumor cells (CTCs) from blood cells for diagnostic purposes in a novel microfluidic device using two active methods: magnetophoresis and dielectrophoresis. The most specific feature of this device is the differentiation of CTCs without labeling them in order to achieve a more reliable and less complicated method. This device was analyzed and evaluated using finite element method. Four cell lines are separated in this device containing red blood cells, platelets, white blood cells, and CTCs. Primarily, red blood cells and...