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Characterization of PAHs and metals in indoor/outdoor PM10 /PM2.5 /PM1 in a retirement home and a school dormitory
,
Article
Science of the Total Environment
;
Volume 527-528
,
September
,
2015
,
Pages 100-110
;
00489697 (ISSN)
; Naddafi, K
; Faridi, S
; Nabizadeh, R
; Sowlat, M. H
; Momeniha, F
; Gholampour, A
; Arhami, M
; Kashani, H
; Zare, A
; Niazi, S
; Rastkari, N
; Nazmara, S
; Ghani, M
; Yunesian, M
;
Sharif University of Technology
Elsevier
2015
Abstract
In the present work, we investigated the characteristics of polycyclic aromatic hydrocarbons (PAHs) and metal(loid)s in indoor/outdoor PM10 , PM2.5 , and PM1 in a retirement home and a school dormitory in Tehran from May 2012 to May 2013. The results indicated that the annual levels of indoor and outdoor PM10 and PM2.5 were much higher than the guidelines issued by the World Health Organization (WHO). The most abundant detected metal(loid)s in PM were Si, Fe, Zn, Al, and Pb. We found higher percentages of metal(loid)s in smaller size fractions of PM. Additionally, the results showed that the total PAHs (ΣPAHs) bound to PM were...
Development of Biocompatible and Fluorescent Platforms Based on Carbon Dots and Deep Eutectic Solvents for Detection of Some Carcinogenic and Antidepressant Compounds
, Ph.D. Dissertation Sharif University of Technology ; Bagheri, Habib (Supervisor)
Abstract
The main focus of this thesis was on fluorescence sensors development based on carbon dots and deep eutectic solvents. Accordingly, an attempt was made to synthesize carbon dots and modified with deep eutectic solvents as biocompatible sensors. Eventually, development and application of these sensors in analytical systems ultimately led to satisfactory and comparable results with previous methods. In the first project, a rapid and miniaturized fluorescent probe based on the ultrasound‒assisted formation of carbon dots (CDs) in a metallic deep eutectic solvent (MDES) was developed and conveniently implemented to detect 4-MeI in commercial dark soft drinks. In-situ synthesis of CDs-chelated...
A mechanistic approach for toxicity and risk assessment of heavy metals, hydroquinone and microorganisms in cosmetic creams
, Article Journal of Hazardous Materials ; Volume 433 , 2022 ; 03043894 (ISSN) ; Shafeeq, A ; Siddiq, U ; Bashir, F ; Ahmad, T ; Athar, M ; Butt, M.T ; Ullah, S ; Mukhtar, A ; Hussien, M ; Lam, S. S ; Sharif University of Technology
Elsevier B.V
2022
Abstract
The demand and importance of fairness creams as a major cosmetic have increased significantly in recent years. However, some of these cosmetics contain heavy metals, hydroquinone and microorganism that can cause various health problems. Therefore, the aim of this study is to determine and examine the concentration of metals (i.e. Cd, Pb, Cr, Ni, Zn, Hg), hydroquinone and microorganisms in nine different fairness creams produced by local and international brands. The health risk assessment of the tested substances for consumers was accessed through systemic exposure dosage (SED), margin of safety (MoS), lifetime cancer risk (LCR), hazard quotient (HQ) and hazard index (HI). The concentration...
Spatiotemporal description of BTEX volatile organic compounds in a middle eastern megacity: tehran study of exposure prediction for environmental health research (Tehran SEPEHR)
, Article Environmental Pollution ; Volume 226 , 2017 , Pages 219-229 ; 02697491 (ISSN) ; Hosseini, V ; Schindler, C ; Hassankhany, H ; Yunesian, M ; Henderson, S. B ; Künzli, N ; Sharif University of Technology
Abstract
The spatiotemporal variability of ambient volatile organic compounds (VOCs) in Tehran, Iran, is not well understood. Here we present the design, methods, and results of the Tehran Study of Exposure Prediction for Environmental Health Research (Tehran SEPEHR) on ambient concentrations of benzene, toluene, ethylbenzene, p-xylene, m-xylene, o-xylene (BTEX), and total BTEX. To date, this is the largest study of its kind in a low- and middle-income country and one of the largest globally. We measured BTEX concentrations at five reference sites and 174 distributed sites identified by a cluster analytic method. Samples were taken over 25 consecutive 2-weeks at five reference sites (to be used for...
Pan-cancer analysis of microRNA expression profiles highlights microRNAs enriched in normal body cells as effective suppressors of multiple tumor types: A study based on TCGA database
, Article PLoS ONE ; Volume 17, Issue 4 April , 2022 ; 19326203 (ISSN) ; Kamal, A ; Es, H. A ; Farhadi, F ; Ebrahimi, M ; Chitsaz, H ; Sharifi Zarchi, A ; Baharvand, H ; Sharif University of Technology
Public Library of Science
2022
Abstract
Background MicroRNAs (miRNAs) are frequently deregulated in various types of cancer. While antisense oligonucleotides are used to block oncomiRs, delivery of tumour-suppressive miRNAs holds great potential as a potent anti-cancer strategy. Here, we aim to determine, and functionally analyse, miRNAs that are lowly expressed in various types of tumour but abundantly expressed in multiple normal tissues. Methods The miRNA sequencing data of 14 cancer types were downloaded from the TCGA dataset. Significant differences in miRNA expression between tumor and normal samples were calculated using limma package (R programming). An adjusted p value < 0.05 was used to compare normal versus tumor miRNA...