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    A validated reduced-order dynamic model of nitric oxide regulation in coronary arteries

    , Article Computers in Biology and Medicine ; Volume 139 , 2021 ; 00104825 (ISSN) Moshfegh, H ; Tajeddini, F ; Pakravan, H. A ; Mahzoon, M ; Azadi Yazdi, E ; Bazrafshan Drissi, H ; Sharif University of Technology
    Elsevier Ltd  2021
    Nitric Oxide (NO) provides myocardial oxygen demands of the heart during exercise and cardiac pacing and also prevents cardiovascular diseases such as atherosclerosis and platelet adhesion and aggregation. However, the direct in vivo measurement of NO in coronary arteries is still challenging. To address this matter, a mathematical model of dynamic changes of calcium and NO concentration in the coronary artery was developed for the first time. The model is able to simulate the effect of NO release in coronary arteries and its impact on the hemodynamics of the coronary arterial tree and also to investigate the vasodilation effects of arteries during cardiac pacing. For these purposes, flow...