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Construction of scaffolds composed of acellular cardiac extracellular matrix for myocardial tissue engineering
, Article Biologicals ; Volume 53 , 2018 , Pages 10-18 ; 10451056 (ISSN) ; Mashayekhan, S ; Ghanbari Asl, S ; Hajebrahimi, Z ; Sharif University of Technology
Academic Press
2018
Abstract
High rates of mortality and morbidity stemming from cardiovascular diseases unveil extreme limitations in current therapies despite enormous advances in medical and pharmaceutical sciences. Following myocardial infarction (MI), parts of myocardium undergo irreversible remodeling and is substituted by a scar tissue which eventually leads to heart failure (HF). To address this issue, cardiac patches have been utilized to initiate myocardial regeneration. In this study, a porous cardiac patch is fabricated using a mixture of decellularized myocardium extracellular matrix (ECM) and chitosan (CS). Results of rheological measurements, SEM, biodegradation test, and MTT assay showed that the...
Biodegradable nanopolymers in cardiac tissue engineering: from concept towards nanomedicine
, Article International Journal of Nanomedicine ; Volume 15 , 2020 , Pages 4205-4224 ; Rabiee, N ; Hajebi, S ; Ahmadi, S ; Fatahi, Y ; Hosseini, M ; Bagherzadeh, M ; Ghadiri, A. M ; Rabiee, M ; Jajarmi, V ; Webster, T. J ; Sharif University of Technology
Dove Medical Press Ltd
2020
Abstract
Cardiovascular diseases are the number one cause of heart failure and death in the world, and the transplantation of the heart is an effective and viable choice for treatment despite presenting many disadvantages (most notably, transplant heart availability). To overcome this problem, cardiac tissue engineering is considered a promising approach by using implantable artificial blood vessels, injectable gels, and cardiac patches (to name a few) made from biodegradable polymers. Biodegradable polymers are classified into two main categories: natural and synthetic polymers. Natural biodegradable polymers have some distinct advantages such as biodegradability, abundant availability, and...