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    Electrically conductive carbon-based (bio)-nanomaterials for cardiac tissue engineering

    , Article Bioengineering and Translational Medicine ; 2022 ; 23806761 (ISSN) Jalilinejad, N ; Rabiee, M ; Baheiraei, N ; Ghahremanzadeh, R ; Salarian, R ; Rabiee, N ; Akhavan, O ; Zarrintaj, P ; Hejna, A ; Saeb, M. R ; Zarrabi, A ; Sharifi, E ; Yousefiasl, S ; Zare, E. N ; Sharif University of Technology
    John Wiley and Sons Inc  2022
    Abstract
    A proper self-regenerating capability is lacking in human cardiac tissue which along with the alarming rate of deaths associated with cardiovascular disorders makes tissue engineering critical. Novel approaches are now being investigated in order to speedily overcome the challenges in this path. Tissue engineering has been revolutionized by the advent of nanomaterials, and later by the application of carbon-based nanomaterials because of their exceptional variable functionality, conductivity, and mechanical properties. Electrically conductive biomaterials used as cell bearers provide the tissue with an appropriate microenvironment for the specific seeded cells as substrates for the sake of... 

    Construction of scaffolds composed of acellular cardiac extracellular matrix for myocardial tissue engineering

    , Article Biologicals ; Volume 53 , 2018 , Pages 10-18 ; 10451056 (ISSN) Esmaeili Pourfarhangi, K ; Mashayekhan, S ; Ghanbari Asl, S ; Hajebrahimi, Z ; Sharif University of Technology
    Academic Press  2018
    Abstract
    High rates of mortality and morbidity stemming from cardiovascular diseases unveil extreme limitations in current therapies despite enormous advances in medical and pharmaceutical sciences. Following myocardial infarction (MI), parts of myocardium undergo irreversible remodeling and is substituted by a scar tissue which eventually leads to heart failure (HF). To address this issue, cardiac patches have been utilized to initiate myocardial regeneration. In this study, a porous cardiac patch is fabricated using a mixture of decellularized myocardium extracellular matrix (ECM) and chitosan (CS). Results of rheological measurements, SEM, biodegradation test, and MTT assay showed that the... 

    Multifunctional conductive biomaterials as promising platforms for cardiac tissue engineering

    , Article ACS Biomaterials Science and Engineering ; Volume 7, Issue 1 , 2021 , Pages 55-82 ; 23739878 (ISSN) Mousavi, A ; Vahdat, S ; Baheiraei, N ; Razavi, M ; Norahan, M. H ; Baharvand, H ; Sharif University of Technology
    American Chemical Society  2021
    Abstract
    Adult cardiomyocytes are terminally differentiated cells that result in minimal intrinsic potential for the heart to self-regenerate. The introduction of novel approaches in cardiac tissue engineering aims to repair damages from cardiovascular diseases. Recently, conductive biomaterials such as carbon- and gold-based nanomaterials, conductive polymers, and ceramics that have outstanding electrical conductivity, acceptable mechanical properties, and promoted cell-cell signaling transduction have attracted attention for use in cardiac tissue engineering. Nevertheless, comprehensive classification of conductive biomaterials from the perspective of cardiac cell function is a subject for...