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Fabrication of a novel 3D scaffold for cartilage tissue repair: In-vitro and in-vivo study
, Article Materials Science and Engineering C ; Volume 128 , 2021 ; 09284931 (ISSN) ; Shamloo, A ; Sharif University of Technology
Elsevier Ltd
2021
Abstract
Self-repairing is not an advanced ability of articular cartilage. Tissue engineering has provided a novel way for reconstructing cartilage using natural polymers because of their biocompatibility and bio-functionality. The purpose of cartilage tissue engineering is to design a scaffold with proper pore structure and similar biological and mechanical properties to the native tissue. In this study, porous scaffolds prepared from gelatin, chitosan and silk fibroin were blended with varying ratios. Between the blends of chitosan (C), gelatin (G) and silk fibroin (S), the scaffold with the weight per volume ratio of 2:2:3 (w/v) showed the most favorable and higher certain properties than the...