Search for: case-control-studies
Total 21 records
Article BMC Oral Health ; Volume 21, Issue 1 , 2021 ; 14726831 (ISSN) ; Gholami, L ; Badrlou, E ; Sadeghpour, S ; Nazer, N ; Shadnoush, M ; Sayad, A ; Taheri, M ; Sharif University of Technology
BioMed Central Ltd 2021
Background: Periodontitis is a chronic inflammatory disorder with a complex etiology. Long non-coding RNAs (lncRNAs) have been shown to affect pathoetiology of periodontitis. We aimed at identification of expression of five lncRNAs, namely Linc0116, Linc00667, CDK6-AS1, FENDRR and DIRC3 in the circulation and gingival tissues of these patients compared with healthy controls. Methods: In a pilot case–control study, we compared expressions of Linc0116, Linc00667, CDK6-AS1, FENDRR and DIRC3 lncRNAs between blood and tissue samples of patients with periodontitis and healthy controls using real time quantitative PCR technique. The present work was performed on samples got from 26 patients with...
Diagnosis of early Alzheimer's disease based on EEG source localization and a standardized realistic head model, Article IEEE Journal of Biomedical and Health Informatics ; Volume 17, Issue 6 , 2013 , Pages 1039-1045 ; 21682194 (ISSN) ; Zahedi, E ; Jalili, M ; Keikhosravi, A ; Vahdat, B. V ; Sharif University of Technology
In this paper, distributed electroencephalographic (EEG) sources in the brain have been mapped with the objective of early diagnosis of Alzheimer's disease (AD). To this end, records from a montage of a high-density EEG from 17 early AD patients and 17 matched healthy control subjects were considered. Subjects were in eyes-closed, resting-state condition. Cortical EEG sources were modeled by the standardized low-resolution brain electromagnetic tomography (sLORETA) method. Relative logarithmic power spectral density values were obtained in the four conventional frequency bands (alpha, beta, delta, and theta) and 12 cortical regions. Results show that in the left brain hemisphere, the theta...
Article IEEE Journal of Biomedical and Health Informatics ; Volume 17, Issue 3 , 2013 , Pages 572-578 ; 21682194 (ISSN) ; Mousavi, S. R ; Vosoughi Vahdat, B ; Sayyah, M ; Sharif University of Technology
This study presents applying recurrence quantification analysis (RQA) on EEG recordings and their subbands: delta, theta, alpha, beta, and gamma for epileptic seizure detection. RQA is adopted since it does not require assumptions about stationarity, length of signal, and noise. The decomposition of the original EEG into its five constituent subbands helps better identification of the dynamical system of EEG signal. This leads to better classification of the database into three groups: Healthy subjects, epileptic subjects during a seizure-free interval (Interictal) and epileptic subjects during a seizure course (Ictal). The proposed algorithm is applied to an epileptic EEG dataset provided...
The effects of anxiety and external attentional focus on postural control in patients with Parkinson’s disease, Article PLoS ONE ; Volume 13, Issue 2 , 2018 ; 19326203 (ISSN) ; Azad, A ; Mehdizadeh, H ; Habibi, S. A ; Mandehgary Najafabadi, M ; Saberi, Z. S ; Rahimzadegan, H ; Moradi, S ; Behzadipour, S ; Parnianpour, M ; Taghizadeh, G ; Khalaf, K ; Sharif University of Technology
Public Library of Science 2018
Background Although anxiety is a common non-motor outcome of Parkinson's disease (PD) affecting 40% of patients, little attention has been paid so far to its effects on balance impairment and postural control. Improvement of postural control through focusing on the environment (i.e. external focus) has been reported, but the role of anxiety, as a confounding variable, remains unclear. Objectives This study aimed to investigate the influence of anxiety and attentional focus instruction on the standing postural control of PD patients. Methods Thirty-four patients with PD (17 with high anxiety (HA-PD) and 17 with low anxiety (LA-PD)), as well as 17 gender- and age-matched healthy control...
Article Journal of Assisted Reproduction and Genetics ; Volume 36, Issue 8 , 2019 , Pages 1743-1752 ; 10580468 (ISSN) ; Shahhoseini, M ; Afsharian, P ; Sharifi Zarchi, A ; Masoudi Nejad, A ; Sharif University of Technology
Springer New York LLC 2019
Purpose: Endometriosis is a gynecological disease that causes the uterine lining to appear in other organs outside the uterus. As DNA methylation has an important role in this disorder, its profiling can reveal new information to improve the diagnosis and treatment of endometriosis patients. Methods: We conducted a genome-wide methylation profiling of ectopic and eutopic endometrial tissues from women with and without endometriosis using Infinium Human Methylation 450K BeadChip arrays. DNA methylation samples were collected from nine ectopic and nine eutopic endometrial tissues of endometriosis and six endometrial tissues of healthy controls. Results: Correlation heatmaps and the principal...
The effects of movement speed on kinematic variability and dynamic stability of the trunk in healthy individuals and low back pain patients, Article Clinical Biomechanics ; Volume 30, Issue 7 , Aug , 2015 , Pages 682-688 ; 02680033 (ISSN) ; Sanjari, M. A ; Mokhtarinia, H. R ; Moeini Sedeh, S ; Khalaf, K ; Parnianpour, M ; Sharif University of Technology
Elsevier Ltd 2015
Background: Comparison of the kinematic variability and dynamic stability of the trunk between healthy and low back pain patient groups can contribute to gaining valuable information about the movement patterns and neuromotor strategies involved in various movement tasks. Methods: Fourteen chronic low back pain patients with mild symptoms and twelve healthy male volunteers performed repeated trunk flexion-extension movements in the sagittal plane at three different speeds: 20 cycles/min, self-selected, and 40 cycles/min. Mean standard deviations, coefficient of variation and variance ratio as variability measures; maximum finite-time Lyapunov exponents and maximum Floquet multipliers as...
Nonlinear dynamical structure of sway path during standing in patients with multiple sclerosis and in healthy controls is affected by changes in sensory input and cognitive load, Article Neuroscience Letters ; Volume 553 , 2013 , Pages 126-131 ; 03043940 (ISSN) ; Sanjari, M. A ; Mofateh, R ; Parnianpour, M ; Sharif University of Technology
Although several studies have applied traditional linear measures to evaluate postural control of patients with multiple sclerosis (MS), little is known about the nonlinear dynamics of this patient group. In this study, recurrence quantification analysis (RQA), a well documented nonlinear method, was used to compare the nonlinear dynamical structure of postural sway in two groups consisting of MS patients (. n=. 23) and healthy matched controls (. n=. 23). The study focuses on three levels of postural difficulty consisting of (1) standing on a rigid surface (force platform) with eyes open, (2) standing on a rigid surface with eyes closed, and (3) standing on a foam surface with eyes closed....
Trunk muscles strength and endurance in chronic low back pain patients with and without clinical instability, Article Journal of Back and Musculoskeletal Rehabilitation ; Volume 25, Issue 2 , 2012 , Pages 123-129 ; 10538127 (ISSN) ; Maroufi, N ; Ebrahimi, I ; Farahmand, F ; Parnianpour, M ; Sharif University of Technology
Objectives: Previous research has shown inconsistent findings regarding muscle endurance in chronic low back pain (CLBP). Questions also remain about muscle endurance in patients with clinical instability. The aim of this study was to investigate trunk muscles strength and endurance in CLBP patients with and without clinical instability. Methods: 32 CLBP patients (15 with and 17 without clinical instability) and 39 matched healthy subjects participated in this study. The standing extension test was performed to assess the strength and endurance of the lumbar extensors while recording their electromyographic activity. The patients' disability was evaluated using the Oswestry and Roland-Morris...
Article Journal of Neurology, Neurosurgery and Psychiatry ; Volume 82, Issue 5 , 2011 , Pages 505-511 ; 00223050 (ISSN) ; Jalili, M ; Frackowiak, R. S ; Rossetti, A. O ; Sharif University of Technology
Objective Psychogenic non-epileptic seizures (PNES) are paroxysmal events that, in contrast to epileptic seizures, are related to psychological causes without the presence of epileptiform EEG changes. Recent models suggest a multifactorial basis for PNES. A potentially paramount, but currently poorly understood factor is the interplay between psychiatric features and a specific vulnerability of the brain leading to a clinical picture that resembles epilepsy. Hypothesising that functional cerebral network abnormalities may predispose to the clinical phenotype, the authors undertook a characterisation of the functional connectivity in PNES patients. Methods The authors analysed the whole-head...
Non-linear dynamical features of center of pressure extracted by recurrence quantification analysis in people with unilateral anterior cruciate ligament injury, Article Gait and Posture ; Volume 31, Issue 4 , 2010 , Pages 450-455 ; 09666362 (ISSN) ; Salavati, M ; Mazaheri, M ; Sanjari, M. A ; Hadian, M. R ; Parnianpour, M ; Sharif University of Technology
Knowledge about the non-linear dynamical pattern of postural sway may provide important insights into the adaptability (flexibility) of human postural control in response to everyday stresses imposed on the body. A commonly used non-linear tool, i.e. recurrence quantification analysis, was chosen to investigate the effect of prior anterior cruciate ligament injury on the deterministic pattern of postural sway under different conditions of postural and cognitive difficulty. In double leg stance, as postural difficulty increased from open-eyes to closed-eyes and rigid-surface to foam-surface, the centre of pressure regularity (%determinism) increased as well. In comparison to healthy...
Article Biomarkers ; Volume 21, Issue 6 , 2016 , Pages 479-489 ; 1354750X (ISSN) ; Aliannejad, R ; Rezaei Tavirani, M ; Arefi Oskouie, A ; Naseri, M. T ; Parastar, H ; Aliakbarzadeh, G ; Fathi, F ; Taheri, S ; Sharif University of Technology
Taylor and Francis Ltd
Sulfur Mustard (SM) is a potent alkylating agent and its effects on cells and tissues are varied and complex. Due to limitations in the diagnostics of sulfur mustard exposed individuals (SMEIs) by noninvasive approaches, there is a great necessity to develop novel techniques and biomarkers for this condition. We present here the first nuclear magnetic resonance (NMR) and gas chromatography-mass spectrometry (GC/MS) metabolic profiling of serum from and healthy controls to identify novel biomarkers in blood serum for better diagnostics. Of note, SMEIs were exposed to SM 30 years ago and that differences between two groups could still be found. Pathways in which differences between SMEIs and...
Kinematic analysis of dynamic lumbar motion in patients with lumbar segmental instability using digital videofluoroscopy, Article European Spine Journal ; Volume 18, Issue 11 , 2009 , Pages 1677-1685 ; 09406719 (ISSN) ; Maroufi, N ; Behtash, H ; Zekavat, H ; Parnianpour, M ; Sharif University of Technology
The study design is a prospective, case-control. The aim of this study was to develop a reliable measurement technique for the assessment of lumbar spine kinematics using digital video fluoroscopy in a group of patients with low back pain (LBP) and a control group. Lumbar segmental instability (LSI) is one subgroup of nonspecific LBP the diagnosis of which has not been clarified. The diagnosis of LSI has traditionally relied on the use of lateral functional (flexion-extension) radiographs but use of this method has proven unsatisfactory. Fifteen patients with chronic low back pain suspected to have LSI and 15 matched healthy subjects were recruited. Pulsed digital videofluoroscopy was used...
The effects of dual-tasking on postural control in people with unilateral anterior cruciate ligament injury, Article Gait and Posture ; Volume 30, Issue 4 , 2009 , Pages 477-481 ; 09666362 (ISSN) ; Hadian, M. R ; Salavati, M ; Mazaheri, M ; Talebian, S ; Jafari, A. H ; Parnianpour, M ; Sharif University of Technology
Several studies have investigated postural control in anterior cruciate ligament (ACL) deficient patients; yet the contribution of cognitive processing (attention) in the postural control of these patients is still unclear. A dual-task design was used to determine the effects of a concurrent digit span memory task on standing balance in a group of ACL patients (n = 27) compared with a group of matched, healthy participants (n = 27). In double limb stance, three levels of postural difficulty were studies on a force platform (rigid surface with eyes open, rigid surface with eyes closed, and foam surface with eyes closed). There were three cognitive conditions (no cognitive task, easy cognitive...
Article Human Antibodies ; Volume 29, Issue 3 , 2021 , Pages 209-216 ; 10932607 (ISSN) ; Movafagh, A ; Badrlou, E ; Nazer, N ; Yari, M ; Sadeghi, G ; Mirzajani, S ; Shadnoush, M ; Sayad, A ; Ghafouri Fard, S ; Sharif University of Technology
IOS Press BV 2021
Signal Transducer and Activator of Transcription (STAT) pathway is functionally located downstream of Janus kinases proteins and can integrate signals from diverse pathways, thus regulating several aspects of immune responses. Although contribution of STAT proteins in the pathogenesis of several inflammatory conditions has been confirmed, their role in the development of periodontitis has been less appraised. Thus, we assessed levels of STAT transcripts in the periodontal tissues and circulation of affected individuals compared with the corresponding controls. Expression of STAT1 was remarkably lower in tissues samples of patients compared with control tissues (Ratio of mean expression (RME)...
Article BMC Cancer ; Volume 19, Issue 1 , 2019 ; 14712407 (ISSN) ; Mostafaei, S ; Etemadi, A ; Ghasemi, A ; Payandeh, M ; Hadifar, S ; Norooznezhad, A. H ; Kazemnejad, A ; Moghoofei, M ; Sharif University of Technology
BioMed Central Ltd 2019
Background: Breast cancer is currently the most common neoplasm diagnosed in women globally. There is a growing body of evidence to suggest that human papillomavirus (HPV) infection may play a key role in invasiveness of breast cancer. The aim of this study was to determine the presence of HPV in patients with breast cancer and its possible association with cancer progression. Methods: Breast specimens were collected from 72 patients with breast cancer and 31 healthy controls. The presence of HPV was investigated by polymerase chain reaction (PCR) and genotyping was performed for positive cases. We also evaluated the viral factors such as E6, E2, and E7 in HPV positive cases. Enzyme-linked...
Article Experimental and Molecular Pathology ; Volume 118 , 2021 ; 00144800 (ISSN) ; Hussen, B. M ; Taheri, F ; Sattari, A ; Yousefi, H ; Omrani, M. D ; Nazer, N ; Ghafouri Fard, S ; Taheri, M ; Sharif University of Technology
Academic Press Inc 2021
Growth arrest-specific gene 6 (GAS6) is a growth factor-like cytokine whose function is related with vitamin K. This protein interacts with receptor tyrosine kinase proteins such as Tyro3, Axl, and TAM Receptor family, therefore affecting the tumorigenic processes via different mechanisms. GAS6-antisense 1 (GAS6-AS1) is a long non-coding RNAs (lncRNAs) that is transcribed from a genomic regions nearby GAS6. This lncRNA is also implicated in the pathobiology of cancer. We intended to judge the role of GAS6 and GAS6-AS1 in the pathogenesis of breast cancer through appraisal of their expression levels in breast cancer tissues and their paired neighboring non-cancerous samples. Expression of...
Article Computers in Biology and Medicine ; Volume 41, Issue 12 , 2011 , Pages 1178-1186 ; 00104825 (ISSN) ; Knyazeva, M. G ; Sharif University of Technology
Schizophrenia is often considered as a dysconnection syndrome in which, abnormal interactions between large-scale functional brain networks result in cognitive and perceptual deficits. In this article we apply the graph theoretic measures to brain functional networks based on the resting EEGs of fourteen schizophrenic patients in comparison with those of fourteen matched control subjects. The networks were extracted from common-average-referenced EEG time-series through partial and unpartial cross-correlation methods. Unpartial correlation detects functional connectivity based on direct and/or indirect links, while partial correlation allows one to ignore indirect links. We quantified the...
Comparison of kinematics of ACL-deficient and healthy knees during passive flexion and isometric leg press, Article Knee ; Volume 20, Issue 6 , December , 2013 , Pages 505-510 ; 09680160 (ISSN) ; Shakourirad, A ; Talebian Moghaddam, S ; Olyaei, G ; Eslami, A ; Farahmand, F ; Sharif University of Technology
Background: Studying the kinematics of the ACL deficient (ACLD) knees, during different physiological activities and muscle contraction patterns, can improve our understanding of the joint's altered biomechanics due to ACL deficiency as well as the efficacy and safety of the rehabilitations exercises. Methods: Twenty-five male volunteers, including 11 normal and 14 unilateral ACLD subjects, participated in this study. The kinematics of the injured knees of the ACLD subjects was compared with their intact knees and the healthy group during passive flexion and isometric leg press with the knees flexed from full extension to 45° flexion, with 15° intervals. An accurate registration algorithm...
Coordination variability during walking and running in individuals with and without patellofemoral pain part 1: lower limb intersegmental coordination variability, Article Journal of Medical and Biological Engineering ; Volume 41, Issue 3 , 2021 , Pages 295-304 ; 16090985 (ISSN) ; Rezaie, M ; Ebrahimi, S ; Shokouhyan, S. M ; Motealleh, A ; Parnianpour, M ; Sharif University of Technology
Springer Science and Business Media Deutschland GmbH 2021
Purpose: Although it has been proposed that individuals with patellofemoral pain show less lower limb intersegmental coordination variability, the evidence to support this hypothesis is rare. The purpose of this study was, therefore, to evaluate whether individuals with patellofemoral pain exhibit less intersegmental coordination variability compared with healthy individuals during walking and running. Also, it was hypothesized that increasing task demand would exacerbate group differences regarding coordination variability measures. Methods: Three-dimensional kinematics were collected while 17 females with patellofemoral pain and 17 healthy females walked at preferred speed, and ran at...
MicroRNAs 29, 150, 155, 223 level and their relation to viral and immunological markers in HIV-1 infected naive patients, Article Future Virology ; Volume 13, Issue 9 , 2018 , Pages 637-645 ; 17460794 (ISSN) ; Bokharaei Salim, F ; Esghaei, M ; Keyvani, H ; Honardoost, M ; Mostafaei, S ; Ghasemi, A ; Tavakoli, A ; Javanmard, D ; Babaei, F ; Garshasbi, S ; Monavari, S. H ; Sharif University of Technology
Aim: The aim of this study was to assess the relationship between microRNAs and viral and immunological markers in HIV-1 infection. Materials & methods: The expression level of miRNAs was evaluated in 60 HIV-1 patients and 20 healthy controls using real-time PCR assays. Results: The results showed that among all miRNAs, miR-29 and miR-150 were significantly downregulated in HIV-1 patients compared with healthy controls, while miR-155 and miR-223 were significantly upregulated compared with healthy controls (p < 0.001 for all comparisons). Conclusion: The mentioned miRNAs seem to influence the clinical progression of HIV-1 infection in naive patients. Moreover, determining the profiles of...