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catecholamine-neurotransmitters
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Identification of catecholamine neurotransmitters using fluorescence sensor array
, Article Analytica Chimica Acta ; Volume 917 , April , 2016 , Pages 85–92 ; 00032670 (ISSN) ; Hormozi Nezhad, M. R ; Mahmoudi, M ; Sharif University of Technology
Elsevier
2016
Abstract
A nano-based sensor array has been developed for identification and discrimination of catecholamine neurotransmitters based on optical properties of their oxidation products under alkaline conditions. To produce distinct fluorescence response patterns for individual catecholamine, quenching of thioglycolic acid functionalized cadmium telluride (CdTe) quantum dots, by oxidation products, were employed along with the variation of fluorescence spectra of oxidation products. The spectral changes were analyzed with hierarchical cluster analysis (HCA) and principal component analysis (PCA) to identify catecholamine patterns. The proposed sensor could efficiently discriminate the individual...
A multichannel single-well sensor array for rapid and visual discrimination of catecholamine neurotransmitters
, Article Sensors and Actuators, B: Chemical ; Volume 296 , 2019 ; 09254005 (ISSN) ; Hormozi Nezhad, M. R ; Maaza, M ; Sharif University of Technology
Elsevier B.V
2019
Abstract
In this study, for rapid identification and discrimination of catecholamine neurotransmitters in the presence of ascorbic acid (AA), a tricolor fluorescence probe has been constructed by integrating three recognition elements including blue carbon dots (bCDs), green CdTe quantum dots (gQDs) and red CdTe quantum dots (rQDs) into a single well. The proposed array exhibited ternary fluorescence emissions at 450, 520 and 630 nm with an overall luminescent pink emission under a single wavelength excitation (365 nm). In order to produce distinct response patterns from a single fluorimetric test, the spectral changes and the corresponding color variations of the multichannel fluorescence probe were...
Identification of catecholamine neurotransmitters using a fluorescent electronic tongue
, Article ACS Chemical Neuroscience ; Volume 11, Issue 1 , November , 2020 , Pages 25-33 ; Bigdeli, A ; Ghazi Khansari, M ; Sasanpour, P ; Hormozinezhad, M. R ; Sharif University of Technology
American Chemical Society
2020
Abstract
Catecholamine neurotransmitters, specifically, dopamine (DA), epinephrine (EP), and norepinephrine (NE), are known as substantial indicators of various neurological diseases. Developing rapid detection methods capable of simultaneously screening their concentrations is highly desired for early clinical diagnosis of such diseases. To this aim, we have designed an optical sensor array using three fluorescent dyes with distinct emission bands and have monitored variations in their emission profiles upon the addition of DA, EP, and NE in the presence of gold ions. Because of the different reducing power of catecholamines, differently sized gold nanoparticles (GNPs) with different levels of...
Identification of catecholamine neurotransmitters using fluorescence sensor array
, Article Analytica Chimica Acta ; Volume 917 , 2016 , Pages 85-92 ; 00032670 (ISSN) ; Hormozi Nezhad, M. R ; Mahmoudi, M ; Sharif University of Technology
Elsevier B.V
2016
Abstract
A nano-based sensor array has been developed for identification and discrimination of catecholamine neurotransmitters based on optical properties of their oxidation products under alkaline conditions. To produce distinct fluorescence response patterns for individual catecholamine, quenching of thioglycolic acid functionalized cadmium telluride (CdTe) quantum dots, by oxidation products, were employed along with the variation of fluorescence spectra of oxidation products. The spectral changes were analyzed with hierarchical cluster analysis (HCA) and principal component analysis (PCA) to identify catecholamine patterns. The proposed sensor could efficiently discriminate the individual...