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A Metabonomics Study of Samples of Different Diseases: Investigation of Linear and Non-Linear Model by Nuclear Magnetic Resonance
, Ph.D. Dissertation Sharif University of Technology ; Tafazzoli, Mohsen (Supervisor)
Abstract
Metabonomics is a quantitative measurement of time dependent metabolic interactions for living systems in response to the pathological or genetic variations. NMR spectroscopy has emerged as a key tool for understanding metabolic processes in living systems. In this project, the study of metabolomics was performed as classification and regression on samples of parkinson’s disease, multiple sclerosis disease, celiac disease and crohn’s disease. In classification part, various methods were applied using optimal parameters.classification methods in Parkinson’s disease, multiple sclerosis disease, celiac disease and crohn’s disease were RF, CART, PLS-DA, RF and RF respectively. Based on the...
The concentration of serum zinc in celiac patients compared to healthy subjects in tehran
, Article Gastroenterology and Hepatology from Bed to Bench ; Volume 6, Issue 2 , 2013 , Pages 92-95 ; 20082258 (ISSN) ; Ektefa, F ; Tafazzoli, M ; Rostami, K ; Nejad, M. R ; Fathi, M ; Rezaye Tavirani, M ; Oskouie, A. A ; Zali, M. R ; Sharif University of Technology
2013
Abstract
Aim: This study evaluated serum levels of zinc in patient with CD compare to healthy subjects. Background: Celiac disease (CD) is characterized by small intestinal malabsorption of nutrients as a consequence of ingestion of wheat gluten. Zinc is an essential trace element that it has vital biological functions. Patients and methods: Sera of 30 celiac cases and 30 healthy normal cohorts as control group were obtained. Atomic absorption spectrophotometer was employed for estimating serum zinc level. Results: Zinc concentrations in patients diagnosed with CD were significantly lower than healthy subjects (75.97±12 compared with 92.83±18, P-value < 0.0001). Conclusion: The result of this study...
NMR based metabonomics study on celiac disease in the blood serum
, Article Gastroenterology and Hepatology from Bed to Bench ; Volume 6, Issue 4 , 2013 , Pages 190-194 ; 20082258 (ISSN) ; Ektefa, F ; Arefi Oskouie, A ; Rostami, K ; Rezaei Tavirani, M ; Mohammad Alizadeh, A. H ; Tafazzoli, M ; Rostami Nejad, M ; Sharif University of Technology
2013
Abstract
Aim: The aim of this study is to look for the proper methods that would be a major step towards untreated CD diagnosis and seek the metabolic biomarkers causes of CD and compare them to control group. Background: Celiac disease (CD) is a common autoimmune disorder that is not easily diagnosed using the clinical tests. Patients and methods: Thirty cases and 30 controls were entered into this study. Metabolic profiling was obtained using proton nuclear magnetic resonance spectroscopy (1HNMR) to seek metabolites that are helpful for the detection of CD. Classification of CD and healthy subject was done using random forest (RF). Results: The obtained classification model showed an 89% correct...
Advantage of applying OSC to 1H NMR-based metabonomic data of celiac disease
, Article International Journal of Endocrinology and Metabolism ; Volume 10, Issue 3 , 2012 , Pages 548-552 ; 1726913X (ISSN) ; Fathi, F ; Darvizeh, F ; Zali, M. R ; Nejad, M. R ; Rostami, K ; Tafazzoli, M ; oskouie, A. A ; Mortazavi Tabatabaei, S. A ; Sharif University of Technology
2012
Abstract
Background: Celiac disease (CD) is a disorder associated with body reaction to gluten. After the gluten intake, an immune reaction against the protein occurs and damages villi of small intestine in celiac patients gradually. Objectives: The OSC, a filtering method for minimization of inter- and intra-spectrom-eter variations that influence on data acquisition, was applied to biofluid NMR data of CD patients. Patients and Methods: In this study, metabolites of total 56 serum samples from 12 CD patients, 15 CD patients taking gluten-free diet (GFD), and 29 healthy cases were analyzed using nuclear magnetic resonance (NMR) and associated theoretical analysis. Employ-ing ProMetab (version...
Development of a nano biosensor for anti-gliadin detection for Celiac disease based on suspension microarrays
, Article Biomedical Physics and Engineering Express ; Volume 6, Issue 5 , August , 2020 ; Rabiee, M ; Rostami Nejad, M ; Aghamohammadi, E ; Asadzadeh Aghdaei, H ; Zali, M. R ; Rabiee, N ; Fatahi, Y ; Bagherzadeh, M ; Webster, T. J ; Sharif University of Technology
IOP Publishing Ltd
2020
Abstract
Celiac disease is an autoimmune disorder represented by the ingestion of the gluten protein usually found in wheat, barley and rye. To date, ELISA has been the most accurate method for determining the presence of anti-gliadin, which is cumbersome, expensive (compared to a suspension microarray technique), and requires extensive sample preparation. In this study, in order to establish a more accurate assay to identify gliadin at lower concentrations, optical nano biosensors using an indirect immunoassay method for gliadin detection was designed and fabricated. For this, polycaprolactone (PCL) nano- to micro-beads were fabricated as a platform for the gliadin antigen which were optimized and...