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    Implementation of Range Doppler Algorithm in Synthetic Aperture Radar

    , M.Sc. Thesis Sharif University of Technology Ebrahimi, Behrouz (Author) ; Vosughi Vahdat, Bijan (Supervisor) ; Nayebi, Mohammad Mehdi (Co-Advisor)
    Today, the use of radar technology and its various applications in different areas of science is no secret. The developed countries are looking to increase their ability to use new radar tools. Synthetic aperture radar is one of the most modern and efficient equipment imaging of the surface. One of the major advantages of synthetic aperture radar is imaging capabilities at night and bad weather conditions if the imaging methods used in the camera have limitations in night and bad weather conditions. There are different methods for extracting the images, one of the most important algorithms is Range Doppler Algorithm which is used to obtaining images from raw data received. Because of the... 

    Analysis and Simulation of Cell Migration with VCM Software

    , M.Sc. Thesis Sharif University of Technology Sadeghizadeh, Sajjad (Author) ; Ejtehadi, Mohammad Reza (Supervisor)
    Cells in their surrounding environment subjected to biochemical and biomechanical stimuli and respond to this signals. The mechanism by which cells transduce external mechanical signals into responses is called Mechanotransduction and cell use this mechanism to sense and respond to extracellular signals. Cells control processes like migration and division by mechanosensing. Cell migration is one of the most important responses to Cell-ECM interaction. This migration underlies many biological processes including embryogenesis, wound healing, tumorogenesis, morphogenesis and immune defense, so the study of cell migration is of particular importance. If there are external signals in cells... 

    Compressed Sensing in SAR

    , M.Sc. Thesis Sharif University of Technology Kamjoo, Mohammad Mahdi (Author) ; Marvasti, Farokh (Supervisor)
    The remote sensing is the knowledge of gaining information about an event without having direct access to it, and synthetic aperture radars (SAR) have gained spectacular attention in this filed due to their wide applications and high efficiency. The performance of SAR, which are classified in the space-borne or space-borne radars is similar to that of pulse radars. The transmitted signals in SAR are generally chirp signals, and the received signal is two-dimensional which is scattered in two dimensions of range and azimuth called as raw data. Due to relative movement between the radar base and the target point, the distance between the radar base and the target point would not be fixed along... 

    Numerical Modeling of Endothelial Cell’s Groups Migration in a Microfluidics Device

    , M.Sc. Thesis Sharif University of Technology Abeddoust, Mohammad (Author) ; Shamloo, Amir (Supervisor)
    Cell migration plays a key role in many biological processes including metastasis, wound healing, inflammatory response, body immune response and formation of new blood vessels. The migration of cells in response to the gradient of concentration gradient is regarded as chemotaxis. In the present study, the group chemotaxis of endothelial cells is simulated in response to gradient concentration of biochemical species using a developed cell migration model. At the first step, the numerical simulation of fluid flow and concentration transport of biochemical species is performed using a developed FVM code. At the second part, a model is developed to mimic the group migration of endothelial... 

    Ground-based moving target imaging in a circular strip-map synthetic aperture radar

    , Article Proceedings of the 2015 IEEE 5th Asia-Pacific Conference on Synthetic Aperture Radar, APSAR 2015, 1 September 2015 through 4 September 2015 ; 2015 , Pages 835-840 ; 9781467372961 (ISBN) Samareh Hashemi, S. R ; Bayat, S ; Nayebi, M. M ; Sharif University of Technology
    Institute of Electrical and Electronics Engineers Inc  2015
    In this paper a novel algorithm for detection, parameter estimation, and image formation of a moving target in ground-based circular strip-map synthetic aperture radar (GBCSAR) is proposed. Because multiple similar scans of the scene with short revisit time are possible, moving target detection is performed by clutter cancellation. Despite of the frequency-domain or multi-antenna clutter cancellation methods, this system has the capability of removing the clutter completely regardless of the target speed or the signal to clutter ratio (SCR). Estimation of target parameters and range-cell migration correction (RCMC) is based on comparing two consecutive target images. Finally the azimuth... 

    Directional migration and differentiation of neural stem cells within three-dimensional microenvironments

    , Article Integrative Biology (United Kingdom) ; Volume 7, Issue 3 , Jan , 2015 , Pages 335-344 ; 17579694 (ISSN) Shamloo, A ; Heibatollahi, M ; Mofrad, M. R. K ; Sharif University of Technology
    Royal Society of Chemistry  2015
    Harnessing neural stem cells to repair neuronal damage is a promising potential treatment for neuronal diseases. To enable future therapeutic efficacy, the survival, proliferation, migration and differentiation of neural stem/progenitor cells (NPCs) should be accurately studied and optimized in in vitro platforms before transplanting these cells into the body for treatment purposes. Such studies can determine the appropriate quantities of the biochemical and biomechanical factors needed to control and optimize NPC behavior in vivo. In this study, NPCs were cultured within a microfluidic device while being encapsulated within the collagen matrix. The migration and differentiation of NPCs were... 

    Induced cell migration based on a bioactive hydrogel sheet combined with a perfused microfluidic system

    , Article Biomedical Materials (Bristol) ; Volume 15, Issue 4 , May , 2020 Jafarkhani, M ; Jafarkhani, M ; Salehi, Z ; Mashayekhan, S ; Kowsari Esfahan, R ; Dolatshahi Pirouz, A ; Bonakdar, S ; Shokrgozar, M. A ; Sharif University of Technology
    Institute of Physics Publishing  2020
    Endothelial cell migration is a crucial step in the process of new blood vessel formation - a necessary process to maintain cell viability inside thick tissue constructs. Here, we report a new method for maintaining cell viability and inducing cell migration using a perfused microfluidic platform based on collagen gel and a gradient hydrogel sheet. Due to the helpful role of the extracellular matrix components in cell viability, we developed a hydrogel sheet from decellularized tissue (DT) of the bovine heart and chitosan (CS). The results showed that hydrogel sheets with an optimum weight ratio of CS/DT = 2 possess a porosity of around 75%, a mechanical strength of 23 kPa, and display cell... 

    Integrative Utilization of Microenvironments, Biomaterials and Computational Techniques for Advanced Tissue Engineering

    , Article Journal of Biotechnology ; Volume 212 , 2015 , Pages 71-89 ; 01681656 (ISSN) Shamloo, A ; Mohammadaliha, N ; Mohseni, M ; Sharif University of Technology
    Elsevier  2015
    This review aims to propose the integrative implementation of microfluidic devices, biomaterials, and computational methods that can lead to a significant progress in tissue engineering and regenerative medicine researches. Simultaneous implementation of multiple techniques can be very helpful in addressing biological processes. Providing controllable biochemical and biomechanical cues within artificial extracellular matrix similar to in vivo conditions is crucial in tissue engineering and regenerative medicine researches. Microfluidic devices provide precise spatial and temporal control over cell microenvironment. Moreover, generation of accurate and controllable spatial and temporal... 

    Advances in skin regeneration: application of electrospun scaffolds

    , Article Advanced Healthcare Materials ; Volume 4, Issue 8 , 2015 , Pages 1114-1133 ; 21922640 (ISSN) Norouzi, M ; Boroujeni, S. M ; Omidvarkordshouli, N ; Soleimani, M ; Sharif University of Technology
    Wiley-VCH Verlag  2015
    The paucity of cellular and molecular signals essential for normal wound healing makes severe dermatological ulcers stubborn to heal. The novel strategies of skin regenerative treatments are focused on the development of biologically responsive scaffolds accompanied by cells and multiple biomolecules resembling structural and biochemical cues of the natural extracellular matrix (ECM). Electrospun nanofibrous scaffolds provide similar architecture to the ECM leading to enhancement of cell adhesion, proliferation, migration and neo tissue formation. This Review surveys the application of biocompatible natural, synthetic and composite polymers to fabricate electrospun scaffolds as skin... 

    Fully-coupled mathematical modeling of actomyosin-cytosolic two-phase flow in a highly deformable moving Keratocyte cell

    , Article Journal of Biomechanics ; Volume 67 , January , 2018 , Pages 37-45 ; 00219290 (ISSN) Nikmaneshi, M. R ; Firoozabadi, B ; Saidi, M. S ; Sharif University of Technology
    Elsevier Ltd  2018
    Interaction between intracellular dynamics and extracellular matrix (ECM) generally occurred into very thin fragment of moving cell, namely lamellipodia, enables all movable cells to crawl on ECM. In fast-moving cells such as fish Keratocytes, Lamellipodia including most cell area finds a fan-like shape during migration, with a variety of aspect ratio function of fish type. In this work, our purpose is to present a novel and more complete two-dimensional continuum mathematical model of actomyosin-cytosolic two-phase flow of a self-deforming Keratocyte with circular spreaded to steady fan-like shape. In the new approach, in addition to the two-phase flow of the F-actin and cytosol, the... 

    Recent advances in the design and applications of amyloid-β peptide aggregation inhibitors for Alzheimer’s disease therapy

    , Article Biophysical Reviews ; Volume 11, Issue 6 , 2019 , Pages 901-925 ; 18672450 (ISSN) Jokar, S ; Khazaei, S ; Behnammanesh, H ; Shamloo, A ; Erfani, M ; Beiki, D ; Bavi, O ; Sharif University of Technology
    Springer  2019
    Alzheimer’s disease (AD) is an irreversible neurological disorder that progresses gradually and can cause severe cognitive and behavioral impairments. This disease is currently considered a social and economic incurable issue due to its complicated and multifactorial characteristics. Despite decades of extensive research, we still lack definitive AD diagnostic and effective therapeutic tools. Consequently, one of the most challenging subjects in modern medicine is the need for the development of new strategies for the treatment of AD. A large body of evidence indicates that amyloid-β (Aβ) peptide fibrillation plays a key role in the onset and progression of AD. Recent studies have reported... 

    Delivery of melittin-loaded niosomes for breast cancer treatment: an in vitro and in vivo evaluation of anti-cancer effect

    , Article Cancer Nanotechnology ; Volume 12, Issue 1 , 2021 ; 18686958 (ISSN) Dabbagh Moghaddam, F ; Akbarzadeh, I ; Marzbankia, E ; Farid, M ; khaledi, L ; Reihani, A. H ; Javidfar, M ; Mortazavi, P ; Sharif University of Technology
    BioMed Central Ltd  2021
    Background: Melittin, a peptide component of honey bee venom, is an appealing candidate for cancer therapy. In the current study, melittin, melittin-loaded niosome, and empty niosome had been optimized and the anticancer effect assessed in vitro on 4T1 and SKBR3 breast cell lines and in vivo on BALB/C inbred mice. "Thin-layer hydration method" was used for preparing the niosomes; different niosomal formulations of melittin were prepared and characterized in terms of morphology, size, polydispersity index, encapsulation efficiency, release kinetics, and stability. A niosome was formulated and loaded with melittin as a promising drug carrier system for chemotherapy of the breast cancer cells.... 

    Defining microRNA signatures of hair follicular stem and progenitor cells in healthy and androgenic alopecia patients

    , Article Journal of Dermatological Science ; Volume 101, Issue 1 , 2021 , Pages 49-57 ; 09231811 (ISSN) Mohammadi, P ; Nilforoushzadeh, M. A ; Youssef, K. K ; Sharifi Zarchi, A ; Moradi, S ; Khosravani, P ; Aghdami, R ; Taheri, P ; Hosseini Salekdeh, G ; Baharvand, H ; Aghdami, N ; Sharif University of Technology
    Elsevier Ireland Ltd  2021
    Background: The exact pathogenic mechanism causes hair miniaturization during androgenic alopecia (AGA) has not been delineated. Recent evidence has shown a role for non-coding regulatory RNAs, such as microRNAs (miRNAs), in skin and hair disease. There is no reported information about the role of miRNAs in hair epithelial cells of AGA. Objectives: To investigate the roles of miRNAs affecting AGA in normal and patient's epithelial hair cells. Methods: Normal follicular stem and progenitor cells, as well as follicular patient's stem cells, were sorted from hair follicles, and a miRNA q-PCR profiling to compare the expression of 748 miRNA (miRs) in sorted cells were performed. Further, we... 

    Expression and function of c1orf132 long-noncoding rna in breast cancer cell lines and tissues

    , Article International Journal of Molecular Sciences ; Volume 22, Issue 13 , 2021 ; 16616596 (ISSN) Shafaroudi, A. M ; Sharifi Zarchi, A ; Rahmani, S ; Nafissi, N ; Mowla, S. J ; Lauria, A ; Oliviero, S ; Matin, M. M ; Sharif University of Technology
    MDPI  2021
    miR-29b2 and miR-29c play a suppressive role in breast cancer progression. C1orf132 (also named MIR29B2CHG) is the host gene for generating both microRNAs. However, the region also expresses longer transcripts with unknown functions. We employed bioinformatics and experimental approaches to decipher C1orf132 expression and function in breast cancer tissues. We also used the CRISPR/Cas9 technique to excise a predicted C1orf132 distal promoter and followed the behavior of the edited cells by real-time PCR, flow cytometry, migration assay, and RNA-seq techniques. We observed that C1orf132 long transcript is significantly downregulated in triple-negative breast cancer. We also identified a... 

    An integrated analysis to predict micro-RNAs targeting both stemness and metastasis in breast cancer stem cells

    , Article Journal of Cellular and Molecular Medicine ; Volume 23, Issue 4 , 2019 , Pages 2442-2456 ; 15821838 (ISSN) Rahimi, M ; Sharifi Zarchi, A ; Firouzi, J ; Azimi, M ; Zarghami, N ; Alizadeh, E ; Ebrahimi, M ; Sharif University of Technology
    Blackwell Publishing Inc  2019
    Several evidences support the idea that a small population of tumour cells representing self-renewal potential are involved in initiation, maintenance, metastasis, and outcomes of cancer therapy. Elucidation of microRNAs/genes regulatory networks activated in cancer stem cells (CSCs) is necessary for the identification of new targets for cancer therapy. The aim of the present study was to predict the miRNAs pattern, which can target both metastasis and self-renewal pathways using integration of literature and data mining. For this purpose, mammospheres derived from MCF-7, MDA-MB231, and MDA-MB468 were used as breast CSCs model. They had higher migration, invasion, and colony formation...