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Formulation and characterization of poly (ethylene glycol)-coated core-shell methionine magnetic nanoparticles as a carrier for naproxen delivery: growth inhibition of cancer cells
, Article Cancers ; Volume 14, Issue 7 , 2022 ; 20726694 (ISSN) ; Yeganeh, A. E ; Yousefi, M ; Far, B. F ; Akbarzadeh, I ; Bokov, D. O ; Raahemifar, K ; Soltani, M ; Sharif University of Technology
MDPI
2022
Abstract
An efficient and selective drug delivery vehicle for cancer cells can remarkably improve therapeutic approaches. In this study, we focused on the synthesis and characterization of magnetic Ni1−x Cox Fe2 O4 nanoparticles (NPs) coated with two layers of methionine and polyethylene glycol to increase the loading capacity and lower toxicity to serve as an efficient drug car-rier. Ni1−x Cox Fe2 O4 @Methionine@PEG NPs were synthesized by a reflux method then charac-terized by FTIR, XRD, FESEM, TEM, and VSM. Naproxen was used as a model drug and its loading and release in the vehicles were evaluated. The results for loading efficiency showed 1 mg of Ni1−x Cox Fe2 O4 @Methionine@PEG NPs could load...
Optimization, physicochemical characterization, and antimicrobial activity of a novel simvastatin nano-niosomal gel against E. coli and S. aureus
, Article Chemistry and Physics of Lipids ; Volume 234 , 2021 ; 00093084 (ISSN) ; Keramati, M ; Azadi, A ; Afzali, E ; Shahbazi, R ; chiani, M ; Norouzian, D ; Bakhshandeh, H ; Sharif University of Technology
Elsevier Ireland Ltd
2021
Abstract
Niosomes, as a kind of drug delivery system, is widely used for the topical delivery of lipophilic drugs. Optimization of niosomes plays an essential role in enhancing their therapeutic efficiencies. This study aims to prepare an optimized niosomal formulation of simvastatin (nSIM), a lipophilic member of statins, through the experiment (Response Surface methodology). Optimized niosomes were characterized in size, polydispersity index (PDI), entrapment efficiency (EE), stability, releasing pattern, and antimicrobial activity. The different molar ratio of surfactant and cholesterol were applied to prepare various formulation of simvastatin loaded niosome. Mean particle size and size...
Optimization, physicochemical characterization, and antimicrobial activity of a novel simvastatin nano-niosomal gel against E. coli and S. aureus
, Article Chemistry and Physics of Lipids ; Volume 234 , 2021 ; 00093084 (ISSN) ; Keramati, M ; Azadi, A ; Afzali, E ; Shahbazi, R ; chiani, M ; Norouzian, D ; Bakhshandeh, H ; Sharif University of Technology
Elsevier Ireland Ltd
2021
Abstract
Niosomes, as a kind of drug delivery system, is widely used for the topical delivery of lipophilic drugs. Optimization of niosomes plays an essential role in enhancing their therapeutic efficiencies. This study aims to prepare an optimized niosomal formulation of simvastatin (nSIM), a lipophilic member of statins, through the experiment (Response Surface methodology). Optimized niosomes were characterized in size, polydispersity index (PDI), entrapment efficiency (EE), stability, releasing pattern, and antimicrobial activity. The different molar ratio of surfactant and cholesterol were applied to prepare various formulation of simvastatin loaded niosome. Mean particle size and size...