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    Design, preparation, and characterization of silk fibroin/carboxymethyl cellulose wound dressing for skin tissue regeneration applications

    , Article Polymer Engineering and Science ; Volume 62, Issue 9 , 2022 , Pages 2741-2749 ; 00323888 (ISSN) Farshi, P ; Salarian, R ; Rabiee, M ; Alizadeh, S ; Gholipourmalekabadi, M ; Ahmadi, S ; Rabiee, N ; Sharif University of Technology
    John Wiley and Sons Inc  2022
    Abstract
    Silk fibroin (SF) has been broadly applied in wound dressing fabrication because of its proper features for wound healing. In this work, we developed a carboxymethyl cellulose (CMC)/gelatin blend film with different concentrations of glycerol, and modified the optimized film with an SF layer through electrospinning process. Tensile strength and cell viability evaluation of blend films demonstrated that the glycerol content of 3% could be suitable as the substrate layer for the two-layer wound dressing. The morphology of the blend film and electrospun nanofibers was obtained from scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). It concluded that...