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Introducing a new definition towards clinical detection of microvascular changes using diffusion and perfusion MRI
, Article Scientia Iranica ; Volume 12, Issue 1 , 2005 , Pages 109-115 ; 10263098 (ISSN) ; Jiang, Q ; Chopp, M ; Jahed, M ; Sharif University of Technology
Sharif University of Technology
2005
Abstract
Based on MRI diffusion and perfusion, a new criterion for detection and the healing progress of damaged tissue is suggested. The study is based on the ratio of capillary radii in symmetrical damaged and normal tissue neighboring spaces. The Apparent Diffusion Coefficient (ADC) and Cerebral Blood Flow (CBF) were measured in the brain tissues of six male Wistar rats utilizing suggested MRI measurement techniques. The ADC values of damaged and normal regions were (392 ± 34.1) × 10-6 mm2s-1 and (659 ± 40.7) × 10-6 mm2s-1, respectively. The CBF values of damaged and normal regions were 14.5 ± 10.13 ml/min/ 100 g and 125 ± 41.03 ml/min/100 g, respectively. The geometrical parameters of the...