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    Estimation of mean radius, length and density of microvasculature using diffusion and perfusion MRI

    , Article Scientia Iranica ; Volume 13, Issue 4 , 2006 , Pages 348-354 ; 10263098 (ISSN) Ashoor, M ; Jahed, M ; Chopp, M ; Mireshghi, A ; Sharif University of Technology
    Sharif University of Technology  2006
    Abstract
    In theory, diffusion and perfusion information in MRI maps can be combined to yield morphological information, such as capillary density, volume and possibly capillary plasma velocity. This paper suggests a new method for determination of mean radius, length and capillary density in normal regions using diffusion and perfusion MRI. Mean Transit Time (MTT), Cerebral Blood Volume (CBV), Apparent Diffusion Coefficient (ADC), pseudo-diffusion coefficient (D*) and ΔR2 and ΔR2* values were utilized to calculate mean radius, length and capillary density. To verify the proposed theory, a special protocol was designed and tested on normal regions of a male Wistar rat using obtained functions. Mean...