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Hexyltriphenylphosphonium bromide as an absolutely chemoselective ionic liquid catalyst in the three-component reaction of aryl aldehydes, acetophenones and malononitrile
, Article ChemistrySelect ; Volume 4, Issue 20 , 2019 , Pages 6190-6193 ; 23656549 (ISSN) ; Khodaei, M. M ; Batooie, N ; Hosseinzadeh, N ; Foroumadi, A ; Sharif University of Technology
Wiley-Blackwell
2019
Abstract
Hexyltriphenylphosphonium bromide (HTPB) is used as an efficient ionic liquid catalyst in the chemoselective addition of malononitrile to carbonyl group moiety of chalcones through the three-component reaction of aryl aldehydes, acetophenone derivatves, and malononitrile to produce (E)-2-(1,3-diarylallylidene)malononitriles at ambient temperature. The method is simple, solvent-free, environmentally friendly, and gives excellent yields in a short reaction times. © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
KF/Al2O3-mediated Michael addition of thiols to electron-deficient olefins
, Article Synthetic Communications ; Volume 35, Issue 18 , 2005 , Pages 2427-2433 ; 00397911 (ISSN) ; Bardajee, G. R ; Veranlou, R. O. C ; Sharif University of Technology
2005
Abstract
Potassium fluoride supported on alumina efficiently catalyzes Michael addition of aromatic and aliphatic thiols to a variety of conjugated alkenes such as α,β-unsaturated carbonyl compounds, carboxylic esters, amides, nitriles and chalcones. The Michael adducts are produced in good to excellent yields and relatively in short times. The catalyst can be recycled for subsequent reactions without any appreciable loss of efficiency. Copyright © Taylor & Francis, Inc
1, 3- Dipolar Cycloaddition Reactions of Azomethine Ylides of Ninhydrin with Chalcones and Investigation of Asymmetric Addition of TMSCN to Imines
,
M.Sc. Thesis
Sharif University of Technology
;
Saidi, Mohammad Reza
(Supervisor)
;
Jadidi, Khosrow
(Supervisor)
;
Mehrdad, Morteza
(Co-Advisor)
Abstract
Part 1
1,3-dipolar cycloaddition reactions offer convenient routes for the construction of a variety of five-membered heterocycles. This thesis represents a simple synthetic method via 1,3-dipolar cycloaddition reaction to prepare a novel class of spiro pyrrolidines and spiro pyrrolizidines which exhibit many biological activities. Non-stabilized azomethine ylides which generated in situ by the decarboxylative condensation of ninhydrin with proline and sarcosine were used as a 1,3-dipoles. On the other hand, chalcone and its derivatives with an impressive array of pharmacological activities were the dipolarophiles in these reactions. The reactions were carried out through reflax...
1,3-dipolar cycloaddition reactions offer convenient routes for the construction of a variety of five-membered heterocycles. This thesis represents a simple synthetic method via 1,3-dipolar cycloaddition reaction to prepare a novel class of spiro pyrrolidines and spiro pyrrolizidines which exhibit many biological activities. Non-stabilized azomethine ylides which generated in situ by the decarboxylative condensation of ninhydrin with proline and sarcosine were used as a 1,3-dipoles. On the other hand, chalcone and its derivatives with an impressive array of pharmacological activities were the dipolarophiles in these reactions. The reactions were carried out through reflax...