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    Straightforward and highly efficient catalyst-free one-pot synthesis of dithiocarbamates under solvent-free conditions

    , Article Organic Letters ; Volume 8, Issue 23, 9 November 2006, Pages 5275-5277 Azizi, N. (Najmodin) ; Aryanadab, F ; Saidi, M. R ; Sharif University of Technology
    Abstract
    A highly efficient and simple synthesis of dithiocarbamates is possible based on the one-pot reaction of amines, CS2, and alkyl halides without using a catalyst under solvent-free conditions. The mild reaction conditions, high yields, and broad scope of the reaction illustrate the good synthetic utility of this method. The reaction is a highly atom-economic process for production of S-alkyl thiocarbamates and successfully can be used in high quantities in the pharmaceutical or agrochemical industries  

    Metal-Organic cubane cage with trimethylplatinum(Iv) vertices

    , Article Inorganic Chemistry ; 2021 ; 00201669 (ISSN) Hendi, Z ; Jamali, S ; Mahmoudi, S ; Samouei, H ; Nayeri, S ; Chabok, S. M. J ; Jamshidi, Z ; Sharif University of Technology
    American Chemical Society  2021
    Abstract
    Herein we describe the synthesis and characterization of the first platinum(IV) metal-organic cage [(Me3PtIV)8(byp)12](OTf)8 (2), in which the organometallic moieties trimethylplatinum(IV) (PtMe3) occupied the corners of a cubane structure and 4,4′-bipyridine ligands used as linkers. The first-principles density functional theory calculations showed that the highest occupied molecular orbitals were localized on the PtMe3 moieties, while the lowest unoccupied molecular orbitals were distributed on the organic linkers. © 2021 American Chemical Society  

    Michael addition reaction of anthrone to nitroolefins in water

    , Article Synthetic Communications ; Volume 43, Issue 5 , May , 2013 , Pages 744-748 ; 00397911 (ISSN) Halimehjani, A. Z ; Karimi, N ; Saidi, M. R ; Sharif University of Technology
    2013
    Abstract
    Michael addition reaction of anthrone to nitroolefins is described in water without using any catalyst to prepare 9-(2-nitro-1-arylethyl)anthracene-10(9H)- ones. This method is green and efficient and gives good yields of products. The solvent effect is also investigated  

    Highly efficient and catalyst-free synthesis of unsymmetrical thioureas under solvent-free conditions

    , Article Tetrahedron Letters ; Volume 50, Issue 1 , 2009 , Pages 32-34 ; 00404039 (ISSN) Ziyaei Halimehjani, A ; Pourshojaei, Y ; Saidi, M. R ; Sharif University of Technology
    2009
    Abstract
    A highly efficient and simple synthesis of unsymmetrical thioureas is reported based on the reaction of readily synthesized dithiocarbamates with amines, without using any catalyst under solvent-free conditions. The short reaction time, high yields, and solvent-free conditions are advantages of this method. We did not observe the formation of any symmetric disubstituted thiourea, under these reaction conditions. © 2008 Elsevier Ltd. All rights reserved  

    Highly chemoselective reductive amination-coupling by one-pot reaction of aldehydes, HMDS and NaBH4

    , Article Tetrahedron Letters ; Volume 49, Issue 47 , 2008 , Pages 6682-6684 ; 00404039 (ISSN) Azizi, N ; Akbari, E ; Khejeh Amiri, A ; Saidi, M. R ; Sharif University of Technology
    2008
    Abstract
    An efficient and highly chemoselective synthesis of symmetrical secondary amines via reductive amination of aldehydes with inexpensive and commercially available HMDS and sodium borohydride in high to quantitative yields is reported. © 2008 Elsevier Ltd. All rights reserved  

    Waste-free and environment-friendly uncatalyzed synthesis of dithiocarbamates under solvent-free conditions

    , Article Synlett ; Issue 18 , 2007 , Pages 2797-2800 ; 09365214 (ISSN) Azizi, N ; Ebrahimi, F ; Aakbari, E ; Aryanasab, F ; Saidi, M.R ; Sharif University of Technology
    2007
    Abstract
    A mild, convenient, and practical one-pot procedure for the direct synthesis of dithiocarbamates has been developed by condensation of amines, CS2, and a Michael acceptor, under solvent-free conditions at room temperature in good to excellent yields. © Georg Thieme Verlag Stuttgart  

    A simple and novel eco-friendly process for the one-pot synthesis of dithiocarbamates from amines, carbon disulfide, and epoxides

    , Article Synlett ; Issue 8 , 2007 , Pages 1239-1242 ; 09365214 (ISSN) Azizi, N ; Pourhasan, B ; Aryanasab, F ; Saidi, M. R ; Sharif University of Technology
    2007
    Abstract
    An environmentally benign, highly efficient, and simple protocol for the synthesis of various structurally divergent dithiocarbamate derivatives in one-pot reaction of amines, carbon disulfide, and epoxides, without using any solvent and catalyst at room temperature, is presented. This new procedure has the advantages of higher yield, lower cost, reduced environmental impact, and simple work-up procedure. © Georg Thieme Verlag Stuttgart  

    Straightforward and highly efficient catalyst-free one-pot synthesis of dithiocarbamates under solvent-free conditions

    , Article Organic Letters ; Volume 8, Issue 23 , 2006 , Pages 5275-5277 ; 15237060 (ISSN) Azizi, N ; Aryanasab, F ; Saidi, M. R ; Sharif University of Technology
    2006
    Abstract
    A highly efficient and simple synthesis of dithiocarbamates is possible based on the one-pot reaction of amines, CS2, and alkyl halides without using a catalyst under solvent-free conditions. The mild reaction conditions, high yields, and broad scope of the reaction illustrate the good synthetic utility of this method. The reaction is a highly atom-economic process for production of S-alkyl thiocarbamates and successfully can be used in high quantities in the pharmaceutical or agrochemical industries. © 2006 American Chemical Society  

    A versatile one-pot synthesis of 2,3,5-tri-substituted thiophenes from thiomorpholides

    , Article Tetrahedron Letters ; Volume 44, Issue 33 , 2003 , Pages 6253-6255 ; 00404039 (ISSN) Matloubi Moghaddam, F ; Zali Boinee, H ; Sharif University of Technology
    Elsevier Ltd  2003
    Abstract
    An efficient method for the preparation of 2,3,5-trisubstituted thiophenes in a one-pot synthesis from thiomorpholides via the thio-Claisen rearrangement was developed. © 2003 Elsevier Ltd. All rights reserved  

    Synthesis of eight-membered hydroquinolines related to alkaloid skeletons via addition of 4-hydroxycoumarin or 4-hydroxypyran-2-one to quinolinium salts

    , Article Tetrahedron ; Volume 66, Issue 21 , Jan , 2010 , Pages 3678-3681 ; 00404020 (ISSN) Matloubi Moghaddam, F ; Mirjafary, Z ; Saeidian, H ; Taheri, S ; Soltanzadeh, B ; Sharif University of Technology
    2010
    Abstract
    A new one-pot synthesis of hitherto unknown polyheterocyclic systems via tandem C-alkylation and intramolecular O-alkylation of 4-hydroxycoumarin or 4-hydroxypyran-2-one with quinolinium salts in excellent yields (71-89%) is reported. The present approach provides a powerful route into polycyclic structures containing nitrogen and oxygen related to alkaloids  

    Reactivity of a new aryl cycloplatinated(ii) complex containing rollover 2,2′-bipyridine: N -oxide toward a series of diphosphine ligands

    , Article New Journal of Chemistry ; Volume 42, Issue 11 , 2018 , Pages 9159-9167 ; 11440546 (ISSN) Shahsavari, H. R ; Babadi Aghakhanpour, R ; Hossein Abadi, M ; Kia, R ; Halvagar, M. R ; Raithby, P. R ; Sharif University of Technology
    Abstract
    Reaction of the electron-rich complex cis-[Pt(p-Me-C6H4)2(SMe2)2] with 2,2′-bipyridine N-oxide, O-bpy occurred by rollover cyclometalation to afford complex [Pt(O-bpy)(p-Me-C6H4)(SMe2)], 1. The obtained complex was characterized using NMR spectroscopy and its solid state structure was determined by the single crystal X-ray diffraction method. The reaction of 1 with seven diphosphine ligands, 1,1-bis(diphenylphosphino)methane (dppm), 1,2-bis(diphenylphosphino)ethane (dppe), 1,3-bis(diphenylphosphino)propane (dppp), 1,4-bis(diphenylphosphino)butane (dppb), N,N-bis(diphenylphosphino)amine (dppa), 1,2-bis(diphenylphosphino)benzene (dppbz) and 1,1′-bis(diphenylphosphino)ferrocene (dppf), in... 

    A facile aerobic copper-catalyzed α-oxygenation of aryl thioacetamides: An efficient access to α-keto aryl thioamides

    , Article Synlett ; Issue 6 , 2008 , Pages 892-896 ; 09365214 (ISSN) Matloubi Moghaddam, F ; Mirjafary, Z ; Saeidian, H ; Jebeli Javan, M ; Sharif University of Technology
    2008
    Abstract
    Copper(II) efficiently catalyzes the aerobic oxidation of aryl thioacetamides into the corresponding α-keto aryl thioamides in moderate to high yields in the presence of K2CO3 under O 2 atmosphere. This protocol is simple, clean, and generates water as the only byproduct. A mechanism is proposed for the reaction course. © Georg Thieme Verlag Stuttgart  

    Efficient method for oxidation of ketones to esters with 4-aminoperoxybenzoic acid supported on silica gel

    , Article Synthetic Communications ; Volume 38, Issue 12 , 2008 , Pages 2037-2042 ; 00397911 (ISSN) Ghazanfari, D ; Hashemi, M. M ; Shahidi Zandi, M ; Sharif University of Technology
    2008
    Abstract
    4-Aminoperoxybenzoic acid supported on silica gel was found to be a versatile and efficient oxidant for the oxidation of ketones to esters. Copyright © Taylor & Francis Group, LLC  

    The stereoselective synthesis of tetrahydrothiopyrano[2,3-b]indole skeletons via tandem reaction of indoline-2-thiones to Baylis-Hillman adduct acetates

    , Article Tetrahedron ; Volume 69, Issue 38 , September , 2013 , Pages 8169-8173 ; 00404020 (ISSN) Moghaddam, F. M ; Foroushani, B. K ; Sobhani, M ; Masoud, N ; Khodabakhshi, M. R ; Weng, N. S ; Sharif University of Technology
    2013
    Abstract
    Indoline-2-thiones (5) were applied as 1,3-dinucleophiles in a tandem reaction with Baylis-Hillman adduct acetates (4) to give novel tetrahydrothiopyrano[2,3-b]indole skeletons (6). The effect of different solvents, bases, and catalysts on the yields and stereochemical outcome was studied in detail. The results indicated that acetonitrile as solvent and K 2CO3 as base, under reflux conditions, were the optimum conditions. Products 6a-6l were obtained in high diastereoselectivity and yield (up to 94%)  

    The role of mscl amphipathic n terminus indicates a blueprint for bilayer-mediated gating of mechanosensitive channels

    , Article Nature Communications ; Volume 7 , 2016 ; 20411723 (ISSN) Bavi, N ; Cortes, D. M ; Cox, C. D ; Rohde, P. R ; Liu, W ; Deitmer, J. W ; Bavi, O ; Strop, P ; Hill, A. P ; Rees, D ; Corry, B ; Perozo, E ; Martinac, B ; Sharif University of Technology
    Nature Publishing Group  2016
    Abstract
    The bacterial mechanosensitive channel MscL gates in response to membrane tension as a result of mechanical force transmitted directly to the channel from the lipid bilayer. MscL represents an excellent model system to study the basic biophysical principles of mechanosensory transduction. However, understanding of the essential structural components that transduce bilayer tension into channel gating remains incomplete. Here using multiple experimental and computational approaches, we demonstrate that the amphipathic N-terminal helix of MscL acts as a crucial structural element during tension-induced gating, both stabilizing the closed state and coupling the channel to the membrane. We... 

    Curcumin as a green fluorescent label to revive the fluorescence property of functionalized graphene oxide nanosheets

    , Article Journal of Drug Delivery Science and Technology ; Volume 45 , June , 2018 , Pages 422-427 ; 17732247 (ISSN) Akbari, E ; Akhavan, O ; Hatamie, S ; Rahighi, R ; Sharif University of Technology
    Editions de Sante  2018
    Abstract
    In this work, graphene oxide (GO) aqueous suspensions prepared by a chemical exfoliation method showed a fluorescence peak at ∼615 nm. Photoluminescence spectroscopy determined that functionalization of the GO sheets by 3-(2-Aminoethylamino) propyltrimethoxysilane molecules significantly quench the fluorescence property of the GO sheets. Fourier transform infrared spectroscopy confirmed proper functionalization of the GO sheets. Curcumin was applied as a fluorescent natural material with an emission peak at ∼550 nm wavelength for green fluorescent labeling of the functionalized-GO sheets. The curcumin-labeled functionalized-GO sheets showed an intense emission band fluorescent property with... 

    A simple and novel eco-friendly process for the synthesis of cyclic dithiocarbonates from epoxides and carbon disulfide in water

    , Article Journal of Heterocyclic Chemistry ; Volume 46, Issue 2 , 2009 , Pages 347-350 ; 0022152X (ISSN) Ziyaei Halimehjani, A ; Ebrahimi, F ; Azizi, N ; Saidi, M. R ; Sharif University of Technology
    2009
    Abstract
    The reaction of oxiranes with carbon disulfide for preparation of cyclic dithiocarbonates was carried out in water under catalytic amount of an organic base such as dimethylaminopyridine or triethylamine. The reaction conditions are simple and give high yields of desired products.© 2009 HeteroCorporation  

    Iron-catalyzed inexpensive and practical synthesis of N-substituted pyrroles in water

    , Article Synlett ; Issue 14 , 2009 , Pages 2245-2248 ; 09365214 (ISSN) Azizi, N ; Khajeh Amiri, A ; Ghafuri, H ; Bolourtchian, M ; Saidi, M. R ; Sharif University of Technology
    2009
    Abstract
    An operationally simple, practical, and economical protocol for iron(III) chloride catalyzed Paal-Knorr pyrrole synthesis in water in good to excellent yields has been developed. Several N-substituted pyrroles are readily prepared from the reaction of 2,5-dimethoxytetrahydrofuran and aryl/alkyl, sulfonyl and acyl amines under very mild reaction conditions. © Georg Thieme Verlag Stuttgart  

    Ligand modifications for tailoring the binuclear microenvironments in schiff-base calixpyrrole pacman complexes

    , Article Inorganic Chemistry ; Volume 48, Issue 15 , 2009 , Pages 7491-7500 ; 00201669 (ISSN) Askarizadeh, E ; Devoille, A. M. J ; Boghaei, D. M ; Slawin, A. M. Z ; Love, J. B ; Sharif University of Technology
    2009
    Abstract
    The synthesis and structures of two new octadentate, Schiff-base calixpyrrole macrocycles are presented in which modifications at the meso-substituents (L1) or the aryl spacer between the two pyrrole-imine donor compartments (L2) are introduced. The outcomes of these changes are highlighted in the structures of binuclear Pacman complexes of these macrocycles, [M2(L1)] and [M2(L 2)]. Both palladium and cobalt complexes of the fluorenylmeso- substituted macrocycle H4L1 adopt rigid, but laterally twisted geometries with enclosed bimetallic microenvironments; a consequence of this spatial constraint is an exo-exo-bonding mode of pyridine in the dicobalt complex [Co2(py)2(L1)]. In contrast, the... 

    Fundamental differences of substrate hydroxylation by high-valent Lron(IV)-Oxo models of cytochrome P450

    , Article Inorganic Chemistry ; Volume 48, Issue 14 , 2009 , Pages 6661-6669 ; 00201669 (ISSN) Tahsini, L ; Bagherzadeh, M ; Nam, W ; De Visser, S. P ; Sharif University of Technology
    2009
    Abstract
    An Iron(lV)-oxo heme(+·) complex (Compound I, Cpd I) is the proposed active species of heme enzymes such as the cytochromes P450 and Is elusive; therefore, biomimetic studies on active site mimics give valuable Insight Into the fundamental properties of heme active species. In this work we present density functional theory (DFT) calculations on substrate hydroxylatlon by a Compound I mimic [FeIV=O(Por+̇)Cl] and its one-electron reduced form [FeIV=O(Por)Cl]-. Thus, recent experimental studies showed that [FeIV =O(Por)Cl]- is able to react with substrates via hydride transfer reactions [Jeong, Y. J.; Kang, Y.; Han, A.-R.; Lee, Y.-M.; Kotani, H.; Fukuzumi, S.; Nam, W. Angew. Chem., Int. Ed....