Sharif Digital Repository

Nowadays, chemotherapy is one of the common ways to treat cancer. Although, chemotherapy is used to kill cancer cells , chemotherapy drugs also target healthy cells and tissues of the body. In practice, it is difficult to strike a balance between injectable doses of drugs and toxicity in the body, and physicians are always looking for an effective treatment plan. One of the most common drugs that physicians use in chemotherapy is cell-cycle-specific drugs. These types of chemotherapy drugs affect only a certain phase of cell cycle and to a certain extent. Since the lifetime of the cancer cells is uncertain, the effective use of these drugs depends on the correct injection time of the drugs... 

Chemotherapy is a proven and effective systematic approach to treat various types of cancers. Despite its advantages, chemotherapy would kill healthy as well as cancer cells. To overcome this problem, different controlling strategies are implemented. This study aims to provide a medicine drug delivery schedule for chemotherapy (by designing a proper controlling system) based on the verifiable mathematical models. First, the dynamic model is analysed and stability points are reviewed. The selected model has five state variables and two inputs. In this study, the focus is on dynamic model analysis and obtaining an effective and appropriate treatment pattern by designing a proper controller. To... 

Best cancer treatment is the one which reduces the tumor density in minimum time and side effects, considering the input limitations. In this paper, tracking controller and robust controllers are designed to achieve the mentioned objectives, simultaneously. An ODE-based mathematical model of the human body under chemovirotherapy is selected, which includes the uninfected and infected tumor cells, free viruses, immune cells, and a chemotherapeutic drug. For tracking purposes, a servo controller based on the entire eigenstructure assignment (EESA) approach is applied to the model, continuously and discretely. For robust purposes H-infinity and D-K iteration approaches are implemented and... 

We consider a system of two coupled integro-differential equations modelling populations of healthy and cancer cells under chemotherapy. Both populations are structured by a phenotypic variables, representing their level of resistance to the treatment. we analyse the asymptotic behaviour of the model under constant infusion of drugs. By designing an appropriate Lyapunov function, we prove that both cell densities converge to Dirac masses. We then define an optimal control problem, by considering all possible infusion protocols and minimising the number of cancer cells over a prescribed time frame. We provide a quasi-optimal strategy and prove that it solves this problem for large final... 

Statistics show that cancer is the second leading cause of death in the world. In recent years, several studies have shown that combination therapy is more effective than single therapy. Modeling and simulation the dynamics of cancer and the immune system and controlling the dose of cancer drugs complement preclinical trials. The aim of this study was to apply the model predictive control approach to determine the optimal dose of chemotherapy and immunotherapy drugs to treat cancerous tumors. Thus, with a preliminary analysis of the analytics, a six-state dynamic model has been selected as a hypothetical patient to advance therapeutic goals. Two sets of parameters for the hypothetical... 

Among scientific fields of study, mathematical programming has high status and its importance has led researchers to develop accurate models and effective solving approaches to addressing optimization problems. In particular, meta-heuristic algorithms are approximate methods for solving optimization problems whereby good (not necessarily optimum) solutions can be generated via their implementation. In this study, we propose a population-based meta-heuristic algorithm according to chemotherapy method to cure cancers that mainly search the infeasible region. As in chemotherapy, Chemotherapy Science Algorithm (CSA) tries to kill inappropriate solutions (cancers and bad cells of the human body);... 

Cancer treatment is one of the most challenging issues of recent years. Extensive researches have been conducted in various fields of medicine, pharmacy, and medical physics in this regard. Today, considering nanotechnology developments, researchers believe that full cancer treatment is possible through the use of nano-systems designed with scientific background to overcome the defects of previous methods. In this research, the main purpose is to design and synthesize multifunctional hybrid nanostructures with favorable optical and magnetic properties providing a way to combine chemotherapy and thermal treatment. Accordingly, two different structures were designed and experimentally... 

Today, cancer mortality is one of the most important problems, even considering the scientific advances that offer more effective solutions to treat some diseases, providing a way to prevent and treat this disease is one of the most important issues that engineers have considered. This is achieved by designing a controller to minimize the size of the cancer tumor population, increase healthy cells, optimize treatment time, and drug dose.To achieve this goal, pharmacokinetic, pharmacodynamic, tumor growth, and healthy cell growth models, and mathematical models for subsystems that affect tumor growth, such as the angiogenic system, have been studied to develop a single mathematical model. In... 

New methods of cancer treatment are always the attention of researchers all over the world, among which the photothermal treatment method is of particular importance. In addition to being easy, this treatment method has the least invasiveness. Studies have shown that combining this method with other methods such as chemotherapy not only can be very effective in destroying tumor tissue, but can significantly reduce the side effects of chemotherapy drugs.In order to apply the photothermal treatment method, an effective photothermal agent is needed. Molybdenum disulfide nanosheets have performed successfully in this field, which have been of great interest, due to their high efficiency in...