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A pilot study of the effect of phospholipid curcumin on serum metabolomic profile in patients with non-alcoholic fatty liver disease: a randomized, double-blind, placebo-controlled trial
, Article European Journal of Clinical Nutrition ; Volume 73, Issue 9 , 2019 , Pages 1224-1235 ; 09543007 (ISSN) ; Mirhafez, S. R ; Dehabeh, M ; Hariri, M ; Azimi Nezhad, M ; Nobakht M. Gh, B. F ; Sharif University of Technology
Nature Publishing Group
2019
Abstract
Background/Objectives: Curcumin, a natural polyphenol compound in the spice turmeric, has been found to have potent anti-oxidative and anti-inflammatory activity. Curcumin may treat non-alcoholic fatty liver disease (NAFLD) through its beneficial effects on biomarkers of oxidative stress (OS) and inflammation, which are considered as two feature of this disease. However, the effects of curcumin on NAFLD have been remained poorly understood. This investigation evaluated the effects of administrating curcumin on metabolic status in NAFLD patients. Subjects/Methods: Fifty-eight NAFLD patients participated in a randomized, double-blind, placebo-controlled parallel design of study. The subjects...