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    Synthesis and characterization of N- diethyl methyl chitosan

    , Article Iranian Polymer Journal (English Edition) ; Volume 13, Issue 5 , 2004 , Pages 431-436+437 ; 10261265 (ISSN) Avadi, M. R ; Mahdavinia, G ; Sadeghi, A. M ; Erfan, M ; Amini, M ; Tehrani, M. R ; Shafiee, A ; Sharif University of Technology
    Biodegradable polymers such as chitosan have been used extensively in biomedical fields in the form of sutures; wound dressing and as artificial skin. Colonic drug delivery for either local or systemic effects has been the subject of much research over the last decade. Chitosan exhibits poor solubility at pH values above 6 that prevent enhancing effects at sites of absorption of drugs. In the present work, N-diethyl methyl chitosan (DEMC) was prepared based on a modified two-step process via a 22 factorial design to optimize the preparative conditions. DEMC Polymer with different degrees of quaternization for pharmacological and pharmaceutical experiments was achieved. The reaction was... 

    Mesoporous silica nanoparticles (MCM-41) coated PEGylated chitosan as a pH-Responsive nanocarrier for triggered release of erythromycin [electronic resource]

    , Article International Journal of Polymeric Materials and Polymeric Biomaterials ; 2014, Volume 63, Issue 13, Pages 692-697 Pourjavadi, A. (Ali) ; Mazaheri Tehrani, Zahra ; Sharif University of Technology
    A pH-responsive drug delivery system based on core shell structure of mesoporous silica nanoparticle (MSN) and chitosan-PEG copolymer was prepared and characterized by Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), scanning electron microscope (SEM), and high-resolution transmission microscope (HR-TEM) techniques. In order to improve compatibility MSN and drug, mesoporous nanosilica was modified by 3-aminopropyl triethoxysilane. The release of erythromycin (a macrolide antibiotic) as a model drug was investigated in two pHs, 7.4 and 5.5  

    Modified Chitosan. 3. Superabsorbency, Salt- and pH-Sensivity of Smart Ampholitic hydrogels from Chitosan-g-PAN [electronic resource]

    , Article Polymers for Advanced Technologies ; Volume 15, Issue 4, pages 173–180, April 2004 Mahdavinia, G. R. (Golam Reza) ; Zohuriaan-Mehr, M. J ; Pourjavadi, M. J
    Polyacrylonitrile (PAN) grafted chitosan was prepared by ceric-initiated graft polymerization of acrylonitrile onto chitosan in a homogenous medium. The copolymer chitosan-g-PAN product was then hydrolyzed to yield a novel smart hydrogel (H-chitoPAN) with superabsorbing properties. The influence of add-on values as well as temperature and time of hydrolysis of the initial chitosan-g-PAN on swelling behavior of the hydrogel was evaluated in water and various salt solutions. The swelling kinetics of the superabsorbing hydrogel was studied as well. The hydrogels exhibited ampholytic and pH-sensitivity characteristics. Several sharp swelling changes were observed in lieu of pH variations in a... 

    Flexible bactericidal graphene oxide–chitosan layers for stem cell proliferation [electronic resource]

    , Article Journal of Applied Surface Science ; 15 May 2014, Volume 301, Pages 456–462 Mazaheri, M ; Akhavan, O ; Simchi, A. (Abdolreza) ; Sharif University of Technology
    Graphene oxide (GO)–chitosan composite layers with stacked layer structures were synthesized using chemically exfoliated GO sheets (with lateral dimensions of ∼1 μm and thickness of ∼1 nm), and applied as antibacterial and flexible nanostructured templates for stem cell proliferation. By increasing the GO content from zero to 6 wt%, the strength and elastic modulus of the layers increased ∼80% and 45%, respectively. Similar to the chitosan layer, the GO–chitosan composite layers showed significant antibacterial activity (>77% inactivation after only 3 h) against Staphylococcus aureus bacteria. Surface density of the actin cytoskeleton fibers of human mesenchymal stem cells (hMSCs) cultured... 

    Batch equilibrium and kinetics studies of Cd (II) ion removal from aqueous solution using porous chitosan hydrogel beads

    , Article Iranian Journal of Chemistry and Chemical Engineering ; Volume 28, Issue 3 , 2009 , Pages 81-89 ; 10219986 (ISSN) Mohammad Beigi, S ; Babapoor, A ; Maghsoodi, V ; Mousavi, S. M ; Rajabi, N ; Sharif University of Technology
    In this study chitosan hydrogel beads with porosity ∼ 0.86 and diameter ∼ 2 ± 0.07 mm were prepared from 85 % deacetylated chitosan for removal of Cd2+ ions from aqueous solutions. Chitosan powder was dissolved into dilute acetic acid as solvent and formed into spherical beads using a phase inversion technique. The effect of temperature, initial concentration of Cd2+ ions, and the period of agitation were perused to achieve the best isotherm model. Freundlich model was better fitted than Langmuir model (R2 > 0.99 and R2> 0.93 respectively, at pH of 6.3, and shaker speed of 200 rpm), the constants of Langmuir and Freundlich models were calculated, which RL value and qmax (mg/g wet weight) at... 

    Fabrication of chitosan/poly(lactic acid)/graphene oxide/TiO2 composite nanofibrous scaffolds for sustained delivery of doxorubicin and treatment of lung cancer

    , Article International Journal of Biological Macromolecules ; 2017 ; 01418130 (ISSN) Samadi, S ; Moradkhani, M ; beheshti, H ; Irani, M ; Aliabadi, M ; Sharif University of Technology
    Elsevier B.V  2017
    In this work, the synthesized graphene oxide/TiO2/doxorubicin (GO/TiO2/DOX) composites were loaded into the chitosan/poly(lactic acid) (PLA) solutions to fabricate the electrospun chitosan/PLA/GO/TiO2/DOX nanofibrous scaffolds via electrospinning process. The synthesized composites and nanofibers were characterized using X-ray powder diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analysis. Three-factor three-level central composite design was used to determine the influence of PLA to chitosan ratio, TiO2/DOX content and GO/TiO2/DOX content on the release of DOX from nanofibrous scaffolds. Drug loading efficiency and drug release behavior from... 

    Synthesis, characterization and mechanistic study of nano chitosan tetrazole as a novel and promising platform for CRISPR delivery

    , Article International Journal of Polymeric Materials and Polymeric Biomaterials ; 2020 Rabiee, N ; Bagherzadeh, M ; Tavakolizadeh, M ; Pourjavadi, A ; Atarod, M ; Webster, T. J ; Sharif University of Technology
    Taylor and Francis Inc  2020
    Here, a newly modified chitosan tetrazole was synthesized and fully characterized for CRISPR technology since by increasing the ratio of nitrogen to other elements, the interaction between the genetic material and this nanomaterial was significantly enhanced. The nanomaterial was added to HEK-293 cells for pCRISPR delivery. The nanomaterials were optimized and showed an acceptable binding ability with DNA due to its increasing zeta potential in the synthesized chitosan tetrazole in comparison with chitosan, as well as considerable transfection efficiency, more than 25%, and, thus, can be considered as a promising and also new gold-standard for the delivery of pCRISPR. © 2020 Taylor & Francis... 

    Modified chitosan III, superabsorbency, salt- and pH-sensitivity of smart ampholytic hydrogels from chitosan-g-PAN

    , Article Polymers for Advanced Technologies ; Volume 15, Issue 4 , 2004 , Pages 173-180 ; 10427147 (ISSN) Mahdavinia, G. R ; Zohuriaan Mehr, M. J ; Pourjavadi, A ; Sharif University of Technology
    John Wiley and Sons Ltd  2004
    Polyacrylonitrile (PAN) grafted chitosan was prepared by ceric-initiated graft polymerization of acrylonitrile onto chitosan in a homogenous medium. The copolymer chitosan-g-PAN product was then hydrolyzed to yield a novel smart hydrogel (H-chitoPAN) with superabsorbing properties. The influence of add-on values as well as temperature and time of hydrolysis of the initial chitosan-g-PAN on swelling behavior of the hydrogel was evaluated in water and various salt solutions. The swelling kinetics of the superabsorbing hydrogel was studied as well. The hydrogels exhibited ampholytic and pH-sensitivity characteristics. Several sharp swelling changes were observed in lieu of pH variations in a... 

    Characterisation and Preparation of Chitosan-nano Diamond Nanocomposite

    , M.Sc. Thesis Sharif University of Technology Delavar Jolfaee, Zahra (Author) ; Shojaei, Akbar (Supervisor)
    Chitosan is a biocompatible and biopolymer with unique characteristics. Nanodiamonds that are basically carbon based nanoparticle have excellent mechanical, thermal stability biocompatibility bahviors. Combination of these two materials helps to the advantage of all the desirable features of both material and compensate low mechanical properties and strength of chitosan. In this study, we examine the composition of different percentages of nanodiamonds in chitosan and effect of modification on properties of the nanocomposites. The thermal behaviour, swelling behaviour and water contact angle of different nanocomposites were analyzed. Finally, to determine the distribution of the... 

    Characterization and antibacterial performance of electrodeposited chitosan–vancomycin composite coatings for prevention of implant-associated infections [electronic resource]

    , Article Journal of Materials Science and Engineering: C ; 1 August 2014, Volume 41, Pages 240–248 Ordikhani, F ; Tamjid, E ; Simchi, A. (Abdolreza) ; Sharif University of Technology
    Orthopaedic implant-associated infections are one of the most serious complications in orthopaedic surgery and a major cause of implant failure. In the present work, drug-eluting coatings based on chitosan containing various amounts of vancomycin were prepared by a cathodic electrophoretic deposition process on titanium foils. A three-step release mechanism of the antibiotic from the films in a phosphate-buffered saline solution was noticed. At the early stage, physical encapsulation of the drug in the hydrogel network controlled the release rate. At the late stage, however, in vitro degradation/deattachment of chitosan was responsible for the controlled release. Cytotoxicity evaluation of... 

    Preparation and evaluation of chitosan-coated eggshell particles as copper(II) biosorbent

    , Article Desalination and Water Treatment ; 2014 ; ISSN: 19443994 Mohammadnezhad, J ; Khodabakhshi-Soreshjani, F ; Bakhshi, H ; Sharif University of Technology
    Preparation and evaluation of chitosan-coated eggshell (CTS-ES) particles as a biosorbent for removal of Cu(II) ions from aqueous media was considered in this research. For this purpose, chitosan was coated on eggshell (ES) particles through precipitation procedure. The coated particles were characterized by Fourier transform infrared, thermogravimetric analysis, and field emission scanning electron microscopy analysis. Kinetic studies showed that coating of chitosan on ES particles improved their Cu(II) adsorption capacity. The removal of Cu(II) ions by either ES or CTS-ES particles followed the pseudo-second-order kinetics, indicating that chemical sorption is the rate-limiting step for... 

    Long-term antibiotic delivery by chitosan-based composite coatings with bone regenerative potential

    , Article Applied Surface Science ; Vol. 317, issue , 2014 , p. 56-66 Ordikhani, F ; Simchi, A ; Sharif University of Technology
    Composite coatings with bone-bioactivity and drug-eluting capacity are considered as promising materials for titanium bone implants. In this work, drug-eluting chitosan-bioactive glass coatings were fabricated by a single-step electrophoretic deposition technique. Drug-loading and -releasing capacity of the composite coatings were carried out using the vancomycin antibiotic. Uniform coatings with a thickness of ∼55 μm containing 23.7 wt% bioactive glass particles and various amounts of the antibiotic (380-630 μg/cm2) were produced. The coatings were bioactive in terms of apatite-forming ability in simulated body fluid and showed favorable cell adhesion and growth. In vitro biological tests... 

    Preparation and evaluation of a [66ga]gallium chitosan complex in fibrosarcoma bearing animal models

    , Article Nukleonika ; Volume 56, Issue 1 , 2011 , Pages 35-40 ; 00295922 (ISSN) Pourjavadi, A ; Akhlaghi, M ; Jalilian, A. R ; Sharif University of Technology
    [66Ga]gallium chitosan complex was prepared with a high radiochemical purity (> 99%) in dilute acetic acid solution. The radiochemical purity of [66Ga]gallium chitosan complex was checked by using paper chromatography technique. The prepared complex solution was injected intratumoral to fibrosarcoma-bearing mice and the leakage of radioactivity from injection site was investigated. Approximately, 85.4% of the injected dose was retained in the injection site 54 h after injection and most of the leaked radioactivity was accumulated in the blood, liver (0.5%) and lung (6.5%)  

    Electrochemical determination of piroxicam on the surface of pyrolytic graphite electrode modified with a film of carbon nanoparticle-chitosan

    , Article Microchimica Acta ; Volume 170, Issue 1 , August , 2010 , Pages 141-146 ; 00263672 (ISSN) Shahrokhian, S ; Jokar, E ; Ghalkhani, M ; Sharif University of Technology
    The electrochemical behavior of the anti-inflammatory drug piroxicam is studied at the surface of a plain pyrolytic graphite electrode modified with chitosan-doped carbon nanoparticles. An electroactive surface was produced by drop-casting a suspension of the modifier and characterized by atomic force microscopy. A remarkable enhancement is found in studies on the cyclic voltammetric response towards piroxicam. This is described on the basis of the thin-layer mass transport regimes within the porous films, which leads to a considerable increase in the active surface area of the electrode. The electrode shows a linear response to piroxicam in the range of 0.05-50 μM, with a detection limit of... 

    Synthesis and characterization of chitosan coating of NiFe2O4 nanoparticles for biomedical applications

    , Article Journal of the Iranian Chemical Society ; Volume 13, Issue 11 , 2016 , Pages 2069-2076 ; 1735207X (ISSN) Ramezani, S ; Ghazitabar, A ; Sadrnezhaad, S. K ; Sharif University of Technology
    Springer Verlag  2016
    Nickel ferrite nanoparticle is a soft magnetic material whose appealing properties as well as various technical applications have rendered it as one of the most attractive class of materials; its technical applications range from its utility as a sensor and catalyst to its utility in biomedical processes. The present paper focuses first on the synthesis of NiFe2O4 nanoparticles through co-precipitation method resulting in calcined nanoparticles that were achieved at different times and at a constant temperature (773 k). Afterward, they were dispersed in water that was mixed by chitosan. Chitosan was bonded on the surface of nanoparticles by controlling the pH of media. In order to assess the... 

    Chitosan nanoparticles enhance the efficiency of methylene blue-mediated antimicrobial photodynamic inactivation of bacterial biofilms: An in vitro study

    , Article Photodiagnosis and Photodynamic Therapy ; Volume 14 , 2016 , Pages 211-217 ; 15721000 (ISSN) Darabpour, E ; Kashef, N ; Mashayekhan, S ; Sharif University of Technology
    Biodegradable chitosan nanoparticles (CSNPs) with an intrinsic antimicrobial activity may be a good choice to improve the effectiveness of antimicrobial photodynamic inactivation (APDI). The aim of this study was to investigate the effect of CSNPs on the efficiency of methylene blue (MB)-mediated APDI of Staphylococcus aureus and Pseudomonas aeruginosa biofilms. We also assessed the phototoxicity of MB + CSNPs towards human fibroblasts. Methods: CSNPs were prepared using ionic gelation method and characterized by dynamic light scattering (DLS) and field-emission scanning electron microscope (FESEM). Biofilms were developed in a 96-well polystyrene plate for 24 h. In vitro phototoxic effect... 

    Superabsorbency, pH-sensitivity and swelling kinetics of partially hydrolyzed chitosan-g-poly(acrylamide) hydrogels

    , Article Turkish Journal of Chemistry ; Volume 30, Issue 5 , 2006 , Pages 595-608 ; 13000527 (ISSN) Pourjavadi, A ; Mahdavinia, G.R ; Sharif University of Technology
    Acrylamide (AAm) monomer was directly grafted onto chitosan using ammonium persulfate (APS) as an initiator and methylenebisacrylamide (MBA) as a crosslinking agent under an inert atmosphere. Two factors affecting the swelling capacity of the obtained hydrogel, AAm and MBA concentrations, were studied. The polymer structures were characterized by FTIR spectroscopy. Water absorbencies of the hydrogels were compared between before and after the alkaline hydrolysis treatment. Saponification of chitosan-g-poly(acrylamide) (chitosan-g-PAAm) with a hot sodium hydroxide solution gave rise to a high water absorbency. Swelling of the hydrogel samples in saline solution (0.15 mol/L NaCl, CaCl2 and... 

    Modified chitosan 4. Superabsorbent hydrogels from poly(acrylic acid-co-acrylamide) grafted chitosan with salt- and pH-responsiveness properties

    , Article European Polymer Journal ; Volume 40, Issue 7 , 2004 , Pages 1399-1407 ; 00143057 (ISSN) Mahdavinia, G. R ; Pourjavadi, A ; Hosseinzadeh, H ; Zohuriaan, M. J ; Sharif University of Technology
    Graft copolymerization of mixtures of acrylic acid (AA) and acrylamide (AAm) onto chitosan was carried out by using potassium persulfate (KPS) as a free radical initiator in the presence of methylenebisacrylamide (MBA) as a crosslinker. The effect of reaction variables, such as MBA concentration and AA/AAm ratio on the water absorbency capacity have been investigated. The polymer structures were confirmed by FTIR spectroscopy. Water absorbencies were compared for the hydrogels before and after alkaline hydrolysis. In the non-hydrolyzed hydrogel, enhanced water absorbency was obtained with increasing AA in monomer feed. However, after saponification, the sample with high AAm ratio exhibited... 

    Modified chitosan. I. Optimized cerium ammonium nitrate-induced synthesis of chitosan-graft-polyacrylonitrile

    , Article Journal of Applied Polymer Science ; Volume 88, Issue 8 , 2003 , Pages 2048-2054 ; 00218995 (ISSN) Pourjavadi, A ; Mahdavinia, G. R ; Zohuriaan Mehr, M. J ; Omidian, H ; Sharif University of Technology
    Chitin was extracted from shrimp shells and then deacetylated to obtain chitosan. The degree of deacetylation of the chitosan was determined to be 0.76 using pH-metric titration. A large number of cyanide functional groups were introduced onto chitosan by grafting with polyacrylonitrile as an efficient way of modification. The graft copolymerization reactions were carried out under argon atmosphere in a homogeneous aqueous phase (containing a small portion of acetic acid) by using eerie ammonium nitrate as an initiator. Evidence of grafting was obtained by comparing FTIR spectra of chitosan and the graft copolymer as well as solubility characteristics of the products. The synthetic... 

    Modeling and comparison of different simulations for release of amoxicillin from chitosan hydrogels

    , Article Polymer - Plastics Technology and Engineering ; Volume 52, Issue 11 , 2013 , Pages 1147-1153 ; 03602559 (ISSN) Mirzaei B., E ; Ramazani S. A., A ; Shafiee, M ; Alemzadeh, I ; Ebrahimi, H ; Sharif University of Technology
    In this research work, different devices made of glutaraldehyde cross-linked chitosan hydrogels loaded by amoxicillin, have been prepared using freeze-drying method. Effects of system parameters such as cross-linker concentration, pH, and gel structure on the morphology and release behavior of devices have been investigated using standard methods. Morphological studies were performed using SEM instrument and controlled releases are followed via spectrophotometeric method. Reaction of glutaraldehyde with chitosan has been studied using FTIR instrument. SEM micrographs have shown that with increasing cross-linker percentage in hydrogel, pore sizes increased where pore size distribution...