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Distribution of HLA alleles and genotypes in patients with chronic inflammatory demyelinating polyneuropathy
, Article Journal of Molecular Neuroscience ; 2021 ; 08958696 (ISSN) ; Akbari, M. T ; Houlden, H ; Mazdeh, M ; Nazer, N ; Rezaei, O ; Taheri, M ; Sayad, A ; Sharif University of Technology
Humana Press Inc
2021
Abstract
Chronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired immunological disorder. Although the precise pathoetiology of CIDP has not been clarified yet, it is believed that both B and T cells of immune system contribute in this disorder. Based on the importance of human leukocyte antigen (HLA) cluster in the regulation of immune responses, this family of proteins is putative determinants of risk of CIDP. We conducted the current investigation to appraise association between HLA alleles/genotypes/haplotypes and risk of CIDP in Iranian patients. HLA-DQB1*02 allele was significantly more prevalent among cases compared with controls (OR [95% CI] = 4.82 [2.06, 11.3], P value =...
Exploring stakeholders and their requirements in the process of home hemodialysis: A literature review
, Article Seminars in Dialysis ; 2021 ; 08940959 (ISSN) ; Pintelon, L ; Martin, H ; Khan, R. A ; Sharif University of Technology
John Wiley and Sons Inc
2021
Abstract
Providing home hemodialysis (HHD) therapy is a complex process that not only requires the use of a complex technology but also involves a diverse group of stakeholders, and each stakeholder has their requirements and may not share a common interest. Bringing them together will require the alignment of their interests. A process management perspective can help to accomplish the alignment of their interests. To align their interests, it is crucial to identify interest groups and understand their interests. The main objective of this paper is to identify the stakeholders and represents their interests as a list of requirements in the HHD process. An extensive literature review has been carried...
Evaluation of trunk muscle activation during the two directions of flexi-bar exercise in people with and without low back pain
, Article Journal of Modern Rehabilitation ; Volume 16, Issue 4 , 2022 , Pages 304-311 ; 2538385X (ISSN) ; Kahrizi, S ; Hoviattalab, M ; Sharif University of Technology
Tehran University of Medical Sciences
2022
Abstract
Introduction: The flexible-bar with a small amplitude of 5 Hz, which transmits vibrations to the trunk, enables the activation of the core muscles that can be used to rehabilitate subjects with low back pain. Two types of exercise direction that can affect trunk muscles of low back pain subjects similar control group are not known. This study aimed to evaluate and compare exercises with two directions of the oscillating flexible poles in people with and without low back pain (LBP). Materials and Methods: Twelve women with Mean±SD age of 28.75±2.92 years, and body mass index (BMI) of 22.31±2.10 kg/m2 and a history of low back pain, and 12 healthy subjects with Mean±SD age of 28.75±2.49 years...
miRNA-encapsulated abiotic materials and biovectors for cutaneous and oral wound healing: Biogenesis, mechanisms, and delivery nanocarriers
, Article Bioengineering and Translational Medicine ; 2022 ; 23806761 (ISSN) ; Yousefiasl, S ; Kumar, A ; Dabbagh Moghaddam, F ; Rahimmanesh, I ; Samandari, M ; Jamwal, S ; Maleki, A ; Mohammadi, A ; Rabiee, N ; Cláudia Paiva-Santos, A ; Tamayol, A ; Sharifi, E ; Makvandi, P ; Sharif University of Technology
John Wiley and Sons Inc
2022
Abstract
MicroRNAs (miRNAs) as therapeutic agents have attracted increasing interest in the past decade owing to their significant effectiveness in treating a wide array of ailments. These polymerases II-derived noncoding RNAs act through post-transcriptional controlling of different proteins and their allied pathways. Like other areas of medicine, researchers have utilized miRNAs for managing acute and chronic wounds. The increase in the number of patients suffering from either under-healing or over-healing wound demonstrates the limited efficacy of the current wound healing strategies and dictates the demands for simpler approaches with greater efficacy. Various miRNA can be designed to induce...
Modeling the Kidney Market in Iran
, M.Sc. Thesis Sharif University of Technology ; Fatemi Ardestani, Farshad (Supervisor)
Abstract
The purpose of this study is to model people's behavior on both sides of the kidney market. The healthy person decides to donate a live kidney (for a certain amount) on the supply side. On the demand side, the patient chooses between the two existing kidney queues, the living kidney and the cadaveric kidney, based on the individual's income and belief from the waiting time in each of the two queues. The sick person faces two critical risks in life: risk of death and kidney failure. To model these two risks, it is assumed that each person has a level of health that consists of two deterministic and stochastic parts. In this way, with a deterministic rate, a person's health level will decrease...
Dynamics of Poverty in Iran
, M.Sc. Thesis Sharif University of Technology ; Keshavarz Haddad, Gholamreza (Supervisor)
Abstract
Eliminating poverty, which is one of the most important objectives of countries, requires a deep understanding of the trends and dynamics of poverty and the distinction between chronic and transient poverty. However, given the lack of high-quality panel data, measuring movements in and out of poverty in developing countries is difficult. In this research, we build a synthetic panel by constructing a consumption model and estimating the first-round consumption of households surveyed in the second round. The analysis of Expenditures and Income Survey (HEIS) for 1398 and 1399 shows that almost 29 percent of urban and rural households were poor in both years. In female-headed households,...
Correlation between trunk-pelvis inter-segmental coordination parameters during walking and disability level in chronic low back pain patients
, Article Journal of Biomedical Physics and Engineering ; Volume 8, Issue 2 , 2018 , Pages 193-202 ; 22517200 (ISSN) ; Kamali, F ; Razeghi, M ; Haghpanah, A ; Sharif University of Technology
Shiraz University of Medical Sciences
2018
Abstract
Background: Chronic low back pain (CLBP) disability has been particularly frustrating because its treatment has been a great therapeutic challenge. Disability has been suggested to depend on different factors that should be found and considered in the medical management. The inter-segmental coordination is often impaired in CLBP subjects; however, to the best of our knowledge, there is no evidence about the relationship between the existence of coordination problems and disability in CLBP patients. Objective: To evaluate the correlation between sagittal plane trunk-pelvis intersegmental coordination parameters during walking and disability level in CLBP patients. Methods: Kinematic data were...
Dysregulation of lncRNAs in autoimmune neuropathies
, Article Scientific Reports ; Volume 11, Issue 1 , 2021 ; 20452322 (ISSN) ; Taheri, M ; Mehvari Habibabadi, J ; Nazer, N ; Sayad, A ; Ghafouri Fard, S ; Sharif University of Technology
Nature Research
2021
Abstract
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and Guillain-Barré syndrome (GBS) are inflammatory neuropathies with different clinical courses but similar underlying mechanisms. Long non-coding RNAs (lncRNAs) might affect pathogenesis of these conditions. In the current project, we have selected HULC, PVT1, MEG3, SPRY4-IT1, LINC-ROR and DSCAM-AS1 lncRNAs to appraise their transcript levels in the circulation of CIDP and GBS cases versus controls. Expression of HULC was higher in CIDP patients compared with healthy persons (Ratio of mean expression (RME) = 7.62, SE = 0.72, P < 0.001). While expression of this lncRNA was not different between female CIDP cases and female...
Chronic subdural hematoma outcome prediction using logistic regression and an artificial neural network
, Article Neurosurgical Review ; Volume 32, Issue 4 , 2009 , Pages 479-484 ; 03445607 (ISSN) ; Rashidi, A ; Zandi Toghani, M ; Behzadi, M ; Asadollahi, M ; Sharif University of Technology
2009
Abstract
Artificial neural networks (ANN) have not been used in chronic subdural hematoma (CSDH) outcome prediction following surgery. We used two methods, namely logistic regression and ANN, to predict using eight variables CSDH outcome as assessed by the Glasgow outcome score (GOS) at discharge. We had 300 patients (213 men and 87 women) and potential predictors were age, sex, midline shift, intracranial air, hematoma density, hematoma thickness, brain atrophy, and Glasgow coma score (GCS). The dataset was randomly divided to three subsets: (1) training set (150 cases), (2) validation set (75 cases), and (3) test set (75 cases). The training and validation sets were combined for regression...
Expression analysis of BDNF, BACE1 and their antisense transcripts in inflammatory demyelinating polyradiculoneuropathy
, Article Multiple Sclerosis and Related Disorders ; Volume 47 , 2021 ; 22110348 (ISSN) ; Mazdeh, M ; Nicknafs, F ; Nazer, N ; Sayad, A ; Taheri, M ; Sharif University of Technology
Elsevier B.V
2021
Abstract
Acute and chronic inflammatory demyelinating polyradiculoneuropathies (AIDP and CIDP) are two immune-related conditions in the peripheral nervous system. In the current study, we assessed expression levels of Beta-secretase (BACE1), brain-derived neurotrophic factor (BDNF) and their antisense transcripts in the peripheral blood of AIDP and CIDP patients compared with age- and sex-matched controls to assess their potential as biomarkers for these conditions. Expressions of BACE1 and BACE1-AS were down-regulated in CIDP cases compared with controls (Ratios of mean expressions=0.01 and 0.03; P values= 1.07E-08, respectively). On the other hand, expressions of BDNF and BDNF-AS were up-regulated...
Distribution of HLA alleles and genotypes in patients with chronic inflammatory demyelinating polyneuropathy
, Article Journal of Molecular Neuroscience ; Volume 72, Issue 3 , 2022 , Pages 574-584 ; 08958696 (ISSN) ; Akbari, M. T ; Houlden, H ; Mazdeh, M ; Nazer, N ; Rezaei, O ; Taheri, M ; Sayad, A ; Sharif University of Technology
Humana Press Inc
2022
Abstract
Chronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired immunological disorder. Although the precise pathoetiology of CIDP has not been clarified yet, it is believed that both B and T cells of immune system contribute in this disorder. Based on the importance of human leukocyte antigen (HLA) cluster in the regulation of immune responses, this family of proteins is putative determinants of risk of CIDP. We conducted the current investigation to appraise association between HLA alleles/genotypes/haplotypes and risk of CIDP in Iranian patients. HLA-DQB1*02 allele was significantly more prevalent among cases compared with controls (OR [95% CI] = 4.82 [2.06, 11.3], P value =...
Expression analysis of protein inhibitor of activated stat in inflammatory demyelinating polyradiculoneuropathy
, Article Frontiers in Immunology ; Volume 12 , 2021 ; 16643224 (ISSN) ; Hussen, B. M ; Nicknafs, F ; Nazer, N ; Sayad, A ; Taheri, M ; Sharif University of Technology
Frontiers Media S.A
2021
Abstract
Protein inhibitors of activated STAT (PIAS) are involved in the regulation of the JAK/STAT signaling pathway and have interactions with NF-κB, p73 and p53. These proteins regulate immune responses; therefore dysregulation in their expression leads to several immune-mediated disorders. In the present study, we examined expression of PIAS1-4 in peripheral blood of patients with acute/chronic inflammatory demyelinating polyradiculoneuropathy (AIDP/CIDP) compared with healthy subjects. We demonstrated down-regulation of all PIAS genes in both AIDP and CIDP cases compared with controls. Similarly, comparisons in gender-based groups revealed down-regulation of these gene0s in patients of each...
Over-Expression of immune-related lncrnas in inflammatory demyelinating polyradiculoneuropathies
, Article Journal of Molecular Neuroscience ; Volume 71, Issue 5 , 2021 , Pages 991-998 ; 08958696 (ISSN) ; Ghafouri-Fard, S ; Mazdeh, M ; Nicknafs, F ; Nazer, N ; Sayad, A ; Taheri, M ; Sharif University of Technology
Humana Press Inc
2021
Abstract
Long non-coding RNAs (lncRNAs) have crucial roles in the pathogenesis of immune-related disorders. However, their role in the pathobiology of inflammatory demyelinating polyradiculoneuropathies remains unclear. In the current study, we measured peripheral expression of four lncRNAs, namely TUG1, FAS-AS1, NEAT1, and GAS5, in patients with acute/chronic inflammatory demyelinating polyradiculoneuropathies (AIDP/CIDP) compared with healthy subjects. Notably, all lncRNAs were over-expressed in patients compared with controls (P < 0.0001 for all lncRNAs). When assessing their expressions in AIDP and CIDP groups separately, TUG1 and NEAT1 were up-regulated in both patient groups compared with...
Design and Simulation of Integrated Bio-Impedance Driver and Sensor Circuits
, M.Sc. Thesis Sharif University of Technology ; Sharifkhani, Mohammad (Supervisor)
Abstract
Cardiovascular diseases stand as leading contributors to human mortality and disability, with heart muscle diseases, particularly acute and chronic failures, prevalent among them. While various diagnostic methods exist, an accurate, non-invasive, portable, easily accessible, and minimally disruptive approach for monitoring, requiring no frequent clinic visits, takes precedence. Early diagnosis and continuous fluid status monitoring through bioimpedance measurements of chest size are crucial in mitigating the mortality associated with these diseases. Utilizing bioimpedance as a non-invasive signal, this system facilitates ongoing vital parameter monitoring, treatment strategy optimization,...
Multijoint coordination during sit-to-stand task in people with non-specific chronic low back pain
, Article Biomedical Engineering - Applications, Basis and Communications ; Volume 25, Issue 1 , 2013 ; 10162372 (ISSN) ; Negahban, H ; Shaterzadeh, M. J ; Mehravar, M ; Salehi, R ; Narimani, R ; Parnianpour, M ; Sharif University of Technology
2013
Abstract
Sit-to-stand (STS) is an important functional task affected by low back pain (LBP). It requires fundamental coordination among all segments of the body to control important performance variables such as body's center of mass (CM) and head positions. This study was conducted to determine whether LBPs could coordinate their multiple joints to achieve the task stability to the same extent as healthy controls. About 11 non-specific chronic LBP and 12 healthy control subjects performed STS task at three postural difficulty levels: rigid surface - open eyes (RO), rigid surface - closed eyes (RC) and narrow surface - closed eyes (NC). Motion variability of seven body segments, CM and head positions...
Trunk muscles strength and endurance in chronic low back pain patients with and without clinical instability
, Article Journal of Back and Musculoskeletal Rehabilitation ; Volume 25, Issue 2 , 2012 , Pages 123-129 ; 10538127 (ISSN) ; Maroufi, N ; Ebrahimi, I ; Farahmand, F ; Parnianpour, M ; Sharif University of Technology
2012
Abstract
Objectives: Previous research has shown inconsistent findings regarding muscle endurance in chronic low back pain (CLBP). Questions also remain about muscle endurance in patients with clinical instability. The aim of this study was to investigate trunk muscles strength and endurance in CLBP patients with and without clinical instability. Methods: 32 CLBP patients (15 with and 17 without clinical instability) and 39 matched healthy subjects participated in this study. The standing extension test was performed to assess the strength and endurance of the lumbar extensors while recording their electromyographic activity. The patients' disability was evaluated using the Oswestry and Roland-Morris...
Principal component analysis of kinematic patterns variability during sit to stand in people with non-specific chronic low back pain
, Article Journal of Mechanics in Medicine and Biology ; Volume 12, Issue 2 , 2012 ; 02195194 (ISSN) ; Tajali, S ; Negahban, H ; Shaterzadeh, M. J ; Salehi, R ; Narimani, R ; Parnianpour, M ; Sharif University of Technology
2012
Abstract
Sit to stand (STS) task requires variability of all body segments to achieve the stability of the important control variables (i.e., center of mass (CM) and head positions). In this study, the possible differences in the variability patterns of various body segments were investigated between 11 chronic low back pain (LBP) and 12 control subjects during STS task through two types of variability analyses; first by calculating the variability of seven limb angles, CM and head positions across 15 trials and second by principal component analysis (PCA) of seven limb angles. Participants performed the task at 3 postural difficulty levels: rigid surface, open eyes (RO), rigid surface, close eyes...
The effects of postural difficulty conditions on variability of joint kinematic patterns during sit to stand task in normals and patients with non-specific chronic low back pain
, Article 2011 1st Middle East Conference on Biomedical Engineering, MECBME 2011, 21 February 2011 through 24 February 2011, Sharjah ; 2011 , Pages 300-303 ; 9781424470006 (ISBN) ; Negahban, H ; Yazdi, M. J. S ; Salehi, R ; Mehravar, M ; Parnianpour, M ; Sharif University of Technology
2011
Abstract
Sit to stand (STS) is one of the most important activities of daily living that is shown to be affected in low back pain (LBP) patients. It requires a fundamental coordination action among all segments (DOFs) of the body in order to control important performance variables such as body's center of mass (CM) within base of support (BOS). In this study, possible differences in joint coordination and variability patterns between chronic LBP and healthy control subjects were investigated during STS task. Eleven adults with nonspecific chronic LBP and 12 healthy controls were recruited in the study. The participants performed the task in 3 exerimental conditions including: rigid surface, open eyes...
Trunk coordination in healthy and chronic nonspecific low back pain subjects during repetitive flexion-extension tasks: Effects of movement asymmetry, velocity and load
, Article Human Movement Science ; Volume 45 , 2016 , Pages 182-192 ; 01679457 (ISSN) ; Sanjari, M. A ; Chehrehrazi, M ; Kahrizi, S ; Parnianpour, M ; Sharif University of Technology
Elsevier
Abstract
Multiple joint interactions are critical to produce stable coordinated movements and can be influenced by low back pain and task conditions. Inter-segmental coordination pattern and variability were assessed in subjects with and without chronic nonspecific low back pain (CNSLBP). Kinematic data were collected from 22 CNSLBP and 22 healthy volunteers during repeated trunk flexion-extension in various conditions of symmetry, velocity, and loading; each at two levels. Sagittal plane angular data were time normalized and used to calculate continuous relative phase for each data point. Mean absolute relative phase (MARP) and deviation phase (DP) were derived to quantify lumbar-pelvis and...
Drug delivery systems and materials for wound healing applications
, Article Advanced Drug Delivery Reviews ; Volume 127 , 2018 , Pages 138-166 ; 0169409X (ISSN) ; Rinoldi, C ; Schot, M ; Saheb Kashaf, S ; Sharifi, F ; Jalilian, E ; Nuutila, K ; Giatsidis, G ; Mostafalu, P ; Derakhshandeh, H ; Yue, K ; Swieszkowski, W ; Memic, A ; Tamayol, A ; Khademhosseini, A ; Sharif University of Technology
Elsevier B.V
2018
Abstract
Chronic, non-healing wounds place a significant burden on patients and healthcare systems, resulting in impaired mobility, limb amputation, or even death. Chronic wounds result from a disruption in the highly orchestrated cascade of events involved in wound closure. Significant advances in our understanding of the pathophysiology of chronic wounds have resulted in the development of drugs designed to target different aspects of the impaired processes. However, the hostility of the wound environment rich in degradative enzymes and its elevated pH, combined with differences in the time scales of different physiological processes involved in tissue regeneration require the use of effective drug...