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    Nanoparticle Translocation Across a Lipid Bilayer:An Investigation into Size and Shape

    , M.Sc. Thesis Sharif University of Technology Shadmani, Peyman (Author) ; Naghdabadi, Reza (Supervisor) ; Montazeri Hedesh, Abbas (Co-Advisor)
    In recent years, application of nanotechnology in medicine is growing rapidly, specially, in the area of drug delivery. One of most import applications of nanotechnology is the using of nanoparticles as a carrier in targeted drug delivery systems. Simulation of drug delivery and prediction of drug release are developing in experimental and industrial areas. Mathematical modeling is used in drug delivery systems because they are time and cost saving and also can be used to predict drug behavior. The aim of this research, is to provide a framework for designing nano drug carriers. To this end, uptake of nanoparticles into different types of cells with different characteristics, in different... 

    Effect of physico-chemical properties of nanoparticles on their intracellular uptake

    , Article International Journal of Molecular Sciences ; Volume 21, Issue 21 , 2020 , Pages 1-20 Sabourian, P ; Yazdani, G ; Ashraf, S. S ; Frounchi, M ; Mashayekhan, S ; Kiani, S ; Kakkar, A ; Sharif University of Technology
    MDPI AG  2020
    Cellular internalization of inorganic, lipidic and polymeric nanoparticles is of great significance in the quest to develop effective formulations for the treatment of high morbidity rate diseases. Understanding nanoparticle–cell interactions plays a key role in therapeutic interventions, and it continues to be a topic of great interest to both chemists and biologists. The mechanistic evaluation of cellular uptake is quite complex and is continuously being aided by the design of nanocarriers with desired physico-chemical properties. The progress in biomedicine, including enhancing the rate of uptake by the cells, is being made through the development of structure–property relationships in...