Search for: clinical-evaluation
Article Biological Cybernetics ; Volume 112, Issue 5 , 2018 , Pages 483-494 ; 03401200 (ISSN) ; Behzadipour, S ; Taghizadeh, G ; Sharif University of Technology
Mathematical modeling of the neuro-musculoskeletal system in healthy subjects has been pursued extensively. In post-stroke patients, however, such models are very primitive. Besides improving our general understanding of how stroke affects the limb motions, they can be used to evaluate rehabilitation strategies by computer simulations before clinical evaluations. A planar neuro-musculoskeletal arm model for post-stroke patients is developed. The main idea is to use a set of new coefficients, Muscle Significance Factors (MSF), to incorporate the effects of stroke in the muscle control performance. The model uses the optimal control theory to mimic the performance of the CNS and a two-link...
Normal postural responses preceding shoulder flexion: Co-activation or asymmetric activation of transverse abdominis?, Article Journal of Back and Musculoskeletal Rehabilitation ; Vol. 27, issue. 4 , 2014 , p. 545-551 ; Maroufi, N ; Ebrahimi, E ; Parnianpour, M ; Farahmand, F ; Sharif University of Technology
BACKGROUND AND OBJECTIVES: It is suggested that activation of the transverse abdominis muscle has a stabilizing effect on the lumbar spine by raising intra-abdominal pressure without added disc compression. However, its feedforward activity has remained a controversial issue. In addition, research regarding bilateral activation of trunk muscles during a unilateral arm movement is limited. The aim of this study was to evaluate bilateral anticipatory activity of trunk muscles during unilateral arm flexion.MATERIALS AND METHODS: Eighteen healthy subjects (aged 25 ± 3.96 years) participated in this study and performed 10 trials of rapid arm flexion in response to a visual stimulus. The...
Diagnosing anterior cruciate ligament injuries using a knee arthrometer: Design, fabrication, and clinical evaluation, Article Biomedical Engineering - Applications, Basis and Communications ; Volume 23, Issue 3 , April , 2011 , Pages 181-192 ; 10162372 (ISSN) ; Sahraei, E ; Shirin, M. B ; Farahmand, F ; Tahmasebi, M. N ; Parnianpour, M ; Sharif University of Technology
Every year many people suffer from knee injuries. Previous studies on patients with knee injuries have shown that about 40% of knee injuries are Ligament injuries, and about 50% of the ligament injuries are the Anterior Cruciate Ligament (ACL) injuries. Along with other methods, knee arthrometers are widely used to diagnose ACL injuries. In the current research, a knee arthrometer was designed and developed to provide a reliable and repeatable measurement of knee laxity under anteriorposterior applied loads. Testretest configurations to examine repeatability of the device resulted in less than 1.5-mm difference for more than 97% of tests under applied loads of up to 90 N. These tests...
Article Journal of Medical and Biological Engineering ; Volume 38, Issue 1 , February , 2018 , Pages 99-105 ; 16090985 (ISSN) ; Madaah Hosseini, H. R ; Taromi, N ; Arasteh, S ; Kazemnejad, S ; Samadi Kuchaksaraei, A ; Sharif University of Technology
Springer Berlin Heidelberg 2018
Biodegradable polymer/bioceramic nanocomposites are osteoconductive and can accelerate healing of bone tissue. In this research, silk fibroin (SF)/titanium dioxide (TiO2) nanocomposites were synthesized using different concentrations of TiO2 nanoparticles (0, 5, 10, 15 and 20 wt%). The SF/TiO2 nanocomposites were studied in terms of bioactivity and biocompatibility. The in vitro assessment of osteoblasts compatibility indicated that SF inclusion rendered nanocomposite biocompatible whereas presence of TiO2 nanoparticles allowed the cells to adhere and grow on nanocomposite surface and enhanced the bioactivity of the composite. © 2017, Taiwanese Society of Biomedical Engineering
Article Journal of Neuroscience Methods ; Volume 341 , 2020 ; Hojjati, H ; Aghajan, H ; Sharif University of Technology
Elsevier B.V 2020
Background: While decoding visual and auditory stimuli using recorded EEG signals has enjoyed significant attention in the past decades, decoding olfactory sensory input from EEG data remains a novelty. Recent interest in the brain's mechanisms of processing olfactory stimuli partly stems from the association of the olfactory system and its deficit with neurodegenerative diseases. New Methods: An olfactory stimulus decoder using features that represent nonlinear behavior content in the recorded EEG data has been introduced for classifying 4 olfactory stimuli in 5 healthy male subjects. Results: We show that by using nonlinear and chaotic features, a subject-specific classifier can be...
A novel approach to spinal 3-D kinematic assessment using inertial sensors: towards effective quantitative evaluation of low back pain in clinical settings, Article Computers in Biology and Medicine ; Volume 89 , 2017 , Pages 144-149 ; 00104825 (ISSN) ; Abedi, M ; Abdollahi, M ; Dehghan Manshadi, F ; Parnianpour, M ; Khalaf, K ; Sharif University of Technology
This paper presents a novel approach for evaluating LBP in various settings. The proposed system uses cost-effective inertial sensors, in conjunction with pattern recognition techniques, for identifying sensitive classifiers towards discriminate identification of LB patients. 24 healthy individuals and 28 low back pain patients performed trunk motion tasks in five different directions for validation. Four combinations of these motions were selected based on literature, and the corresponding kinematic data was collected. Upon filtering (4th order, low pass Butterworth filter) and normalizing the data, Principal Component Analysis was used for feature extraction, while Support Vector Machine...
Findings of DTI-p maps in comparison with T 2 /T 2 -FLAIR to assess postoperative hyper-signal abnormal regions in patients with glioblastoma 08 Information and Computing Sciences 0801 Artificial Intelligence and Image Processing, Article Cancer Imaging ; Volume 18, Issue 1 , 2018 ; 14707330 (ISSN) ; Safari, M ; Ameri, A ; Shojaee Moghadam, M ; Arbabi, A ; Tabatabaeefar, M ; Salighehrad, H ; Sharif University of Technology
BioMed Central Ltd 2018
Purpose: The aim of this study was to compare diffusion tensor imaging (DTI) isotropic map (p-map) with current radiographically (T 2/T 2 -FLAIR) methods based on abnormal hyper-signal size and location of glioblastoma tumor using a semi-automatic approach. Materials and methods: Twenty-five patients with biopsy-proved diagnosis of glioblastoma participated in this study. T 2, T 2 -FLAIR images and diffusion tensor imaging (DTI) were acquired 1 week before radiotherapy. Hyper-signal regions on T 2, T 2 -FLAIR and DTI p-map were segmented by means of semi-automated segmentation. Manual segmentation was used as ground truth. Dice Scores (DS) were calculated for validation of semiautomatic...
A pilot study of the effect of phospholipid curcumin on serum metabolomic profile in patients with non-alcoholic fatty liver disease: a randomized, double-blind, placebo-controlled trial, Article European Journal of Clinical Nutrition ; Volume 73, Issue 9 , 2019 , Pages 1224-1235 ; 09543007 (ISSN) ; Mirhafez, S. R ; Dehabeh, M ; Hariri, M ; Azimi Nezhad, M ; Nobakht M. Gh, B. F ; Sharif University of Technology
Nature Publishing Group 2019
Background/Objectives: Curcumin, a natural polyphenol compound in the spice turmeric, has been found to have potent anti-oxidative and anti-inflammatory activity. Curcumin may treat non-alcoholic fatty liver disease (NAFLD) through its beneficial effects on biomarkers of oxidative stress (OS) and inflammation, which are considered as two feature of this disease. However, the effects of curcumin on NAFLD have been remained poorly understood. This investigation evaluated the effects of administrating curcumin on metabolic status in NAFLD patients. Subjects/Methods: Fifty-eight NAFLD patients participated in a randomized, double-blind, placebo-controlled parallel design of study. The subjects...
A new postural stability-indicator to predict the level of fear of falling in Parkinson's disease patients, Article BioMedical Engineering Online ; Volume 19, Issue 1 , 2020 ; Behzadipour, S ; Ramezani, M ; Joghataei, M. T ; Shahidi, G. A ; Sharif University of Technology
BioMed Central 2020
Background: Fear of falling (FoF) is defined as a lasting concern about falling that causes a person to limit or even stop the daily activities that he/she is capable of. Seventy percent of Parkinson's disease (PD) patients report activity limitations due to FoF. Timely identification of FoF is critical to prevent its additional adverse effects on the quality of life. Self-report questionnaires are commonly used to evaluate the FoF, which may be prone to human error. Objectives: In this study, we attempted to identify a new postural stability-indicator to objectively predict the intensity of FoF and its related behavior(s) in PD patients. Methods: Thirty-eight PD patients participated in the...
Coordination variability during walking and running in individuals with and without patellofemoral pain part 1: lower limb intersegmental coordination variability, Article Journal of Medical and Biological Engineering ; Volume 41, Issue 3 , 2021 , Pages 295-304 ; 16090985 (ISSN) ; Rezaie, M ; Ebrahimi, S ; Shokouhyan, S. M ; Motealleh, A ; Parnianpour, M ; Sharif University of Technology
Springer Science and Business Media Deutschland GmbH 2021
Purpose: Although it has been proposed that individuals with patellofemoral pain show less lower limb intersegmental coordination variability, the evidence to support this hypothesis is rare. The purpose of this study was, therefore, to evaluate whether individuals with patellofemoral pain exhibit less intersegmental coordination variability compared with healthy individuals during walking and running. Also, it was hypothesized that increasing task demand would exacerbate group differences regarding coordination variability measures. Methods: Three-dimensional kinematics were collected while 17 females with patellofemoral pain and 17 healthy females walked at preferred speed, and ran at...
Article Biomedical Signal Processing and Control ; Volume 45 , 2018 , Pages 256-266 ; 17468094 (ISSN) ; Salarieh, H ; Behzadipour, S ; Tavakoli, M ; Sharif University of Technology
Elsevier Ltd 2018
A bilateral impedance controller is presented to enable robot-assisted surgery of a beating heart. For this purpose, two desired impedance models are designed and realized for the master and slave robots interacting with the operator (surgeon) and the environment (heart tissue), respectively. The impedance models are designed such that (a) the slave robot complies with the oscillatory motion of the beating heart and (b) the surgeon perceives the non-oscillatory portion of the slave/heart contact force at the master robot implying arrested-heart surgery. These performance goals are achieved via appropriate adjustment of the impedance model parameters without any measurement or estimation of...
Preparation, physicochemical properties, in vitro evaluation and release behavior of cephalexin-loaded niosomes, Article International Journal of Pharmaceutics ; Volume 569 , 2019 ; 03785173 (ISSN) ; Akbarzadeh, I ; Tavakkoli Yaraki, M ; Lajevardi, A ; Fatemizadeh, M ; Heidarpoor Saremi, L ; Sharif University of Technology
Elsevier B.V 2019
In this study, optimized cephalexin-loaded niosomal formulations based on span 60 and tween 60 were prepared as a promising drug carrier system. The niosomal formulations were characterized using a series of techniques such as scanning electron microscopy, Fourier transformed infrared spectroscopy, dynamic light scattering, and zeta potential measurement. The size and drug encapsulation efficiency are determined by the type and composition of surfactant. The developed niosomal formulations showed great storage stability up to 30 days with low change in size and drug entrapment during the storage, making them potential candidates for real applications. Moreover, the prepared niosomes showed...
Article Carbohydrate Research ; Volume 487 , 2020 ; Forouzandehdel, S ; Rezghi Rami, M ; Sharif University of Technology
Elsevier Ltd 2020
The magnetic composite hydrogel was fabricated by the graft copolymerization of itaconic acid (IA) onto starch and Alginic acid in the presence graphene sheets (Gr) and Fe3O4 nanoparticles (Fe3O4@Gr-IA/St-Alg) for Guaifenesin (GFN) delivery and wound healing. The Fe3O4@Gr-IA/St-Alg biomaterial is a hydrogel network endowed the material with magnetic property. In addition, GFN not only achieved effectively bound to the magnetic hydrogel, but also released in a controlled manner. The using external magnetic field has significantly positive influence on the drug release rate. To close, these hydrogel drug carriers offer a favorable platform for magnetically targeted drug delivery as well as a...
Article Biomaterials Science ; Volume 8, Issue 4 , 2020 , Pages 1127-1136 ; Mostafavi, E ; Shokrgozar, M. A ; Tamjid, E ; Webster, T. J ; Annabi, N ; Simchi, A ; Sharif University of Technology
Royal Society of Chemistry 2020
The delivery of growth factors is often challenging due to their short half-life, low stability, and rapid deactivation. In native tissues, the sulfated residual of glycosaminoglycan (GAG) polymer chains of proteoglycans immobilizes growth factors through the proteoglycans'/proteins' complexation with nanoscale organization. These biological assemblies can influence growth factor-cell surface receptor interactions, cell differentiation, cell-cell signaling, and mechanical properties of the tissues. Here, we introduce a facile procedure to prepare novel biomimetic proteoglycan nanocarriers, based on naturally derived polymers, for the immobilization and controlled release of growth factors....