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collagen-receptor
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Cooperation within von Willebrand factors enhances adsorption mechanism
, Article Journal of the Royal Society Interface ; Volume 12, Issue 109 , 2015 ; 17425689 (ISSN) ; Mehrbod, M ; Ejtehadi, M. R ; Mofrad, M. R ; Sharif University of Technology
Royal Society of London
2015
Abstract
von Willebrand factor (VWF) is a naturally collapsed protein that participates in primary haemostasis and coagulation events. The clotting process is triggered by the adsorption and conformational changes of the plasma VWFs localized to the collagen fibres found near the site of injury. We develop coarse-grained models to simulate the adsorption dynamics of VWF flowing near the adhesive collagen fibres at different shear rates and investigate the effect of factors such as interaction and cooperativity of VWFs on the success of adsorption events. The adsorption probability of a flowing VWF confined to the receptor field is enhanced when it encounters an adhered VWF in proximity to the...