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Cytochrome 4z1 expression is associated with poor prognosis in colon cancer patients
, Article OncoTargets and Therapy ; Volume 14 , 2021 , Pages 5249-5260 ; 11786930 (ISSN) ; Alshammari, F. O. F. O ; Youssef, A. M. M ; Al Sarayreh, S ; Almuhaisen, G. H ; Alnawaiseh, N ; Al Shuneigat, J. M ; Alrawashdeh, H. M ; Sharif University of Technology
Dove Medical Press Ltd
2021
Abstract
Purpose: Colon cancer is a leading cause of mortality worldwide. It has a relatively poor prognosis; therefore, new therapies are needed. One of the tumour-related enzymes that has gained considerable interest is CYP4Z1. This enzyme has been expressed in many tumours and has been hypothesized as a potential biomarker or target for novel anticancer therapies. Patients and Methods: CYP4Z1 overexpression was immunohistochemically examined in a large panel of colon tissue types including normal, benign, primary and metastatic ones, and the enzyme’s relation to histopathological features and patient survival was evaluated. Results: A high CYP4Z1 expression was observed in benign, primary and...
Chemotherapy Treatment Scheduling via Feedback Linearization Approach and Mixed Integer Programming Method
, M.Sc. Thesis Sharif University of Technology ; Salarieh, Hassan (Supervisor) ; Alasty, Aria ($item.subfieldsMap.e)
Abstract
Cancer is one of the leading causes of death in the world accounting for 7.6 million deaths (around 13% of all deaths) in 2008. Deaths from cancer worldwide are projected to continue rising, with an estimated 13.1 million deaths in 2030 according to WHO. Cancer is a disease caused by normal cells changing so that they grow in an uncontrolled way. There are over 200 different types of cancer because there are over 200 different types of body cells. Various types of treatments are available among them surgery, radiotherapy and chemotherapy are the three major ones. Mathematical models and control theories can be employed to improve the quality of treatment and obtain systematic strategies of...
mRNA-miRNA Interaction Network Analysis on Stages of Colorectal Cancer Abstract
, M.Sc. Thesis Sharif University of Technology ; Roostaazad, Reza (Supervisor) ; Najafi, Ali (Supervisor)
Abstract
Liver metastasis is the leading cause of death in patients with colorectal cancer (CRC). An increasing number of studies have shown that mRNAs, miRNAs, can play an important role in various biological processes that are related to cancer. Identifying and determining the relationship between them can help to diagnose and treat cancer.The aim of this study is to identify miRNA and molecular mRNA markers in the stage of polyp formation in order to diagnose colorectal cancer early and also to introduce therapeutic targets in the stage of metastasis.In this study, two microarray data sets GPL15207 and GPL16384 were analyzed to identify different miRNAs and mRNAs from the GEO database in three...
Exploring Pivot Genes and Clinical Prognosis Using Combined Bioinformatics Approaches in the Colon Cancer
,
M.Sc. Thesis
Sharif University of Technology
;
Foroughmand Araabi, Mohammad Hadi
(Supervisor)
Abstract
Colorectal cancer (CRC) is one of the most common cause of cancer death worldwide. Identification of pivot genes in colorectal cancer can play an important role as biomarkers in predicting and early diagnosis and reducing the number of deaths caused by this disease. In this study, the aim of which is to discover pivot genes in colorectal cancer, six microarray datasets selected from the GEO database including 277 tumor tissue samples and 325 normal colon tissue samples. After data processing, differentially expressed genes and CRC-related genes were screened and 285 shared genes between them were identified for subsequent analysis. Based on 285 shared genes, the protein-protein interaction...
Real-time Automatic Detection and Classification of Colorectal Polyps during Colonoscopy using Interpretable Artificial Intelligence
, M.Sc. Thesis Sharif University of Technology ; Rabiee, Hamid Reza (Supervisor)
Abstract
Cancer is the leading cause of death worldwide, and colorectal cancer is the second leading cause of death in women and the third in men. On the other hand, colon polyps can cause colorectal cancer. Therefore, early detection of polyps is of great importance. In recent years, many methods have been proposed for polyp detection using deep learning with high accuracy, but most of them have problems with speed, accuracy, or interpretability. Speed is important because colonoscopy should be performed as quickly and promptly as possible, and in many cases, it is not possible to repeat the colonoscopy. In addition, many of them only address the issue of polyp detection, while from a medical point...
Photo-destruction of cancer cells by NIR irradiation and graphene nano-sheets
, Article Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011, 13 June 2011 through 16 June 2011, Boston, MA ; Volume 3 , 2011 , Pages 236-239 ; 9781439871386 (ISBN) ; Mohajerzadeh, S ; Janmaleki, M ; Akhavan, O ; Azimi, S ; Clean Technology and Sustainable Industries Organization (CTSI); European Patent Office; Greenberg Traurig; Innovation and Materials Science Institute; Jackson Walker L.L.P ; Sharif University of Technology
2011
Abstract
The photo-thermal therapy using nano-materials has attracted great attention as an efficient strategy for the next generation of cancer treatments. Recently, photo-thermal therapy based on nano-materials that can be activated by a skin-penetrating NIR (Near Infra Red) irradiation has been suggested as a noninvasive, harmless, and highly efficient therapeutic technique. Graphene nano-layers synthesized by a bio-compatible method, with reduced toxicity, will be a suitable candidate for the photo-thermal therapeutic agent. A significant amount of heat is generated upon excitation with near-infrared light (NIR, 700-1100nm) which is transparent to biological species including skins. In this...
Screening of glypican-6 expression in benign, primary and metastatic colon cancers
, Article Clinical Medicine Insights: Oncology ; Volume 15 , 2021 ; 11795549 (ISSN) ; Alshammari, F. O. F. O ; Youssef, A. M. M ; Al Sarayreh, S ; Al Sarayra, Y. M ; Aborajooh, E ; Al Shuneigat, J ; Alrawashdeh, H. M ; Sharif University of Technology
SAGE Publications Ltd
2021
Abstract
Background: The development of colon cancer has been described as a multistep process of carcinogenesis. Understanding molecular and cellular changes underlying this process is required to determine potential biomarkers and therapeutic targets in colon cancers. Several molecular entities, including glypicans, are implicated in cancer development. Among these is glypican-6, which is overexpressed in a limited number of cancers. This study aims to characterise the glypican-6 expression in different types of colon cancer. Methods: Immunohistochemistry was used to characterise glypican-6 expression in a panel of archived formalin-fixed, paraffin-embedded colon tissue types. These types included...