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UV-prepared salep-based nanoporous hydrogel for controlled release of tetracycline hydrochloride in colon
, Article Journal of Photochemistry and Photobiology B: Biology ; Volume 102, Issue 3 , March , 2011 , Pages 232-240 ; 10111344 (ISSN) ; Pourjavadi, A ; Ghavami, S ; Soleyman, R ; Jafarpour, F ; Sharif University of Technology
2011
Abstract
A highly swelling nanoporous hydrogel (NPH) was synthesized via UV-irradiation graft copolymerization of acrylic acid (AA) onto salep backbone and its application as a carrier matrix for colonic delivery of tetracycline hydrochloride (TH) was investigated. Optimized synthesis of the hydrogel was performed by the classic method. The swelling behavior of optimum hydrogel was measured in different media. The hydrogel formation was confirmed by Fourier transform infrared spectroscopy (FTIR) and thermo-gravimetric analysis (TGA/DTG/DTA). The study of the surface morphology of hydrogels using SEM showed a nanoporous (average pore size: about 350 nm) structure for the sample obtained under...